Q9K016

PR
Gene name
murB
Protein name
UDP-N-acetylenolpyruvoylglucosamine reductase
Names
UDP-N-acetylmuramate dehydrogenase
Species
Neisseria meningitidis serogroup B (strain MC58)
KEGG Pathway
nme:NMB0811
EC number
1.3.1.98: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

199-289 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9K016

Entry ID Method Resolution Chain Position Source
AF-Q9K016-F1 Predicted AlphaFoldDB

No variants for Q9K016

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9K016

No associated diseases with Q9K016

3 regional properties for Q9K016

Type Name Position InterPro Accession
domain FAD linked oxidase, N-terminal 33 - 131 IPR006094
domain UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal 174 - 254 IPR011601
domain FAD-binding domain, PCMH-type 15 - 169 IPR016166

Functions

Description
EC Number 1.3.1.98 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
UDP-N-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQPIRYRTDL TPYNTFGLRA QARAFIALEH ADELRDIVRL LEFDRDTVLW LGGGSNILLM
70 80 90 100 110 120
QDYAGLVVHM ENKGIREIAR SDGMVLIEAQ AGEIWHDFVL HTVALGLSGL ENLSLIPGTV
130 140 150 160 170 180
GASPVQNIGA YGVEAKDVIH SVRCFDLDTE TFVELANADC RFAYRESLFK QEGKGRYVIV
190 200 210 220 230 240
SVVFALKTHF VPTLGYGDLA AAVAELSAGR VPTAKDVSDA VCAIRNSKLP NPNVLGNVGS
250 260 270 280 290 300
FFKNPVVSAE KAATLLQRHP DMPRYPQPDG SVKLAAGWLI DQCRLKGFQI GGAAVHDRQA
310 320 330 340
LVLVNKNNAS ANDVRQLAQH IKFTVFARFQ VELHAEPNWL PASFSL