Q9JVX8

PR
Gene name
dnaE (NMA0632)
Protein name
DNA polymerase III subunit alpha
Names
Species
Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
KEGG Pathway
nma:NMA0632
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

879-949 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JVX8

Entry ID Method Resolution Chain Position Source
AF-Q9JVX8-F1 Predicted AlphaFoldDB

No variants for Q9JVX8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9JVX8

No associated diseases with Q9JVX8

4 regional properties for Q9JVX8

Type Name Position InterPro Accession
domain Heat shock protein DnaJ, cysteine-rich domain 133 - 210 IPR001305
domain DnaJ domain 4 - 81 IPR001623
domain Chaperone DnaJ, C-terminal 120 - 331 IPR002939
conserved_site DnaJ domain, conserved site 47 - 66 IPR018253

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEPTYIPLR LHTEFSITDG MVRIKKLIAK AQEYGLPALG ISDLMNEFGL VKFYKACRSA
70 80 90 100 110 120
GIKPIGAADV RIGNPDAPDK PFRAMLIIRN DAGYLRLSEL LTAAYVGKDR NVHHAELNPE
130 140 150 160 170 180
WLENGDNSGL ICLSGAHYGE VGVNLLNGNE DAARAAALKY AAWFPDAFYL ELQRLPERPE
190 200 210 220 230 240
WEACVSGSVK LAEELGLPVV ATHPTQFMSR DDFNAHEARV CIAGGWVLTD KKRPRDFTPS
250 260 270 280 290 300
QFFIPPETMA ERFSDLPEAL ENTVEIAKRC NLHITLGKNF LPLFPTPDGL SLDDYLVKLS
310 320 330 340 350 360
NEGLQERMVQ LYPDEAERAA KMPEYQERLD FELNIIIQMK FPGYFLIVQD FINWAKTHGC
370 380 390 400 410 420
PVGPGRGSGA GSLVAYSLKI TDLDPLKYAL LFERFLNPER VSMPDFDVDF CQANRGRVIE
430 440 450 460 470 480
YVREKYGAEA VSQIVTFGTM SSKAVIRDVG RVLELPFTLC DKLSKLIPLE ANKPLGLDDA
490 500 510 520 530 540
MKAEPQIQEL IEAEEADELI TLAKKLEDLT RGLGMHAGGV LIAPGKISDY SPVYQADESA
550 560 570 580 590 600
SPVSMYDKGD VEDVGLVKFD FLGLRNLTII EMAQNNIKNT TGDIVDVGTI PLDDQTAYQI
610 620 630 640 650 660
FRDANTTAVF QFESTGMKKM LKTAHTTKFE ELIAFVSLYR PGPMDNIPDF VARMKGQEFQ
670 680 690 700 710 720
YIHPLLEGIL APTYGIMVYQ EQVMQAAQII GGYSLGGADL LRRAMGKKKP EEMVKHREIF
730 740 750 760 770 780
AEGAAKQGIS REKSDEIFNY MEKFAGYGFN KSHAAAYALI SYQTAWLKAH YPAEFMAATM
790 800 810 820 830 840
SSELDNTDQL KHFYDDCRAN GIEFLPPDIN ESDYRFTPYP DMKIRYALGA IKGTGEAAVE
850 860 870 880 890 900
SITSARQSGG KFTGLLDFCE RVGKEHMNRR TLEALIRGGA FDSIEPNRAM LLANIDLAMN
910 920 930 940 950 960
NADQKAANAN QGGLFDMMED AIEPVRLIDA PMWSESEKLA EEKTVIGFYL SGHPFGPYAQ
970 980 990 1000 1010 1020
EVRQIAPQKL SKLKPQDSVR LAGFVTAVRT MMGKRGKIAF VSLEDLSGQV EIMVGGQTLE
1030 1040 1050 1060 1070 1080
NCADCLKADQ VLIIESKVSR DDYGGGDGLR ILANQVMTLQ TARERYARSL SLALAPHHDI
1090 1100 1110 1120 1130 1140
GELVQLLAAH QLPDTPRIPL QLSYANEKAS GRLQVPPKWT VTPSSALFGE LETLLGSRSV
RVNW