Q9JM61
Gene name |
Thsd1 (Tmtsp) |
Protein name |
Thrombospondin type-1 domain-containing protein 1 |
Names |
Transmembrane molecule with thrombospondin module |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56229 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JM61
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JM61-F1 | Predicted | AlphaFoldDB |
No variants for Q9JM61
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9JM61 | |||||
No associated diseases with Q9JM61
1 regional properties for Q9JM61
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Thrombospondin type-1 (TSP1) repeat | 339 - 392 | IPR000884 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| extracellular matrix binding | Binding to a component of the extracellular matrix. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| focal adhesion assembly | The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. |
| hematopoietic progenitor cell differentiation | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPMLKDFSN | LLLVVLCDYV | LGEAEYLLLQ | EPVHVALSDR | TVSVGFHYLS | DVNGTLRNVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMLWEANTNR | TLTTKYLLTN | QAQGTLQFEC | FYFKEAGDYW | FVMIPEVTDN | GTQVPLWEKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFLKVEWPVF | HIDLNRTAKA | AEGTFQVGVF | TTQPLCLFPV | DKPDMLVDVI | FTDRLPEARA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLGQPLEIRA | SKRTKLTQGQ | WVEFGCAPVG | VEAYVTVMLR | LLGQDSVIAS | TGPIDLAQKF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GYKLMMAPEV | TCESVLEVMV | LPPPCVFVQG | VLAVYKEAPK | RPEERTFQVA | ENRLPLGERR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TVFNCTLFDV | GKNKYCFNFG | IVKKGHFSAK | ECMLIQRNIE | TWGPWQPWSP | CSTTCGDAVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ERRRLCVTSF | PSRPSCSGMS | SETSPCSLEE | CAVFRPPGPS | PVSPQDPVKS | NNVVTVTGIS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LCLFIIFATV | LITLWRRFGR | APKCSTPVRH | NSIHSPGFRK | NSDEENICEL | SEPRGSFSDA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GDGPRGSPGD | TGIPLTYRCS | ASAPPEDEAS | GSESFQSNAQ | KIIPPLFSYR | LAQQQLKEMK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKGLTETTKV | YHVSQSPLTD | TVVDATASPP | LDLECPEEAA | ASKFRIKSPF | LDQPGAGTGE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RPPSRLDGIV | PPPGCAVSPS | QTLIQKSQIR | STGGRDGSSE | RCHSRSSLFR | RTASFHETKQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SRPFRERSLS | ALTPRQVPAY | SSRMRTWDQM | EDRCRPPSRS | THLLPERPEH | FQGAGRTSSP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGPLSKSYTV | GHPRRKPDPG | DRQAGLVAGA | EKMEPHRAHR | GPSPSHRSAS | RKQSSPIFLK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DSYQKVSQLS | PSHFRKDKCQ | SFPIHPEFAF | YDNTSFRLTE | AEQRMLDLPG | YFGSNEEDET |
| 850 | |||||
| TSTLSVEKLV | I |