AiPD: Autoinhibited Protein Database

Gene name	Trpc4ap
Protein name	Short transient receptor potential channel 4-associated protein
Names	Trp4-associated protein, Trpc4-associated protein, Protein TAP1, Rabex-5/Rin2-interacting protein, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:56407
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

319-397 (Predicted disordered autoinhibitory region) PR

319-397 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JLV2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388601179	58	T>VSDG*	No	EVA
rs3388601660	60	T>I	No	EVA
rs3388605229	98	L>H	No	EVA
rs3388605316	162	M>L	No	EVA
rs3388606594	170	L>M	No	EVA
rs3388605563	216	G>VSDG*	No	EVA
rs3388607468	218	K>E	No	EVA
rs3388596970	253	I>F	No	EVA
rs3388596980	276	S>N	No	EVA
rs3388601652	310	S>*	No	EVA
rs250781560	347	E>D	No	EVA
rs3388601152	421	N>D	No	EVA
rs13466894	421	N>K	No	EVA
rs3388601150	448	C>Y	No	EVA
rs3388601625	455	K>R	No	EVA
rs3392498661	459	L>V	No	EVA
rs3388601144	481	L>P	No	EVA
rs3388601165	560	L>P	No	EVA
rs3388605599	591	K>R	No	EVA
rs3388602956	601	N>S	No	EVA
rs3388598651	632	T>I	No	EVA
rs3388595553	636	D>Y	No	EVA
rs3388603025	652	E>D	No	EVA
rs3388605518	662	V>M	No	EVA
rs3388605552	674	N>K	No	EVA
rs3388605603	674	N>Y	No	EVA
rs3388605724	681	L>Q	No	EVA
rs3388607458	720	K>N	No	EVA
rs3388605299	726	L>F	No	EVA
rs3388601119	788	M>K	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9JLV2

		Description
EC Number
Subcellular Localization	Cytoplasm, perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Cul4-RING E3 ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
Cul4A-RING E3 ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

Name	Definition
phosphatase binding	Binding to a phosphatase.
ubiquitin ligase-substrate adaptor activity	The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.

Name	Definition
hair follicle maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins