Q9JLC4

PR
Gene name
Sorcs1 (Sorcs)
Protein name
VPS10 domain-containing receptor SorCS1
Names
Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3, mSorCS
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

73-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JLC4

Entry ID Method Resolution Chain Position Source
AF-Q9JLC4-F1 Predicted AlphaFoldDB

No variants for Q9JLC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9JLC4

No associated diseases with Q9JLC4

4 regional properties for Q9JLC4

Type Name Position InterPro Accession
domain PKD domain 807 - 879 IPR000601
domain VPS10 196 - 796 IPR006581
domain Sortilin, C-terminal 638 - 791 IPR031777
domain Sortilin, N-terminal 206 - 634 IPR031778

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UPU3 SORCS3 VPS10 domain-containing receptor SorCS3 Homo sapiens (Human) PR
Q8WY21 SORCS1 VPS10 domain-containing receptor SorCS1 Homo sapiens (Human) PR
10 20 30 40 50 60
MGKVGAGDGS SAGLSALLAG AGLLMLLAPG VCSSLSCCPP QHPSSTPRRT LTPRGFPHPG
70 80 90 100 110 120
PLGRAPATPP PLFMRPLFAV APGDRALFLE RAGGSRVSVA TAARSGRRRR SGTEPEKIEP
130 140 150 160 170 180
GEGASRSRRD MLKDGGQQGL GTGARDPGKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW
190 200 210 220 230 240
SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK
250 260 270 280 290 300
CKIMLLTDPE IESSLLISSD EGATYQKYRL NFYLQSLLFH PKQEDWILAY SQDQKLYSSA
310 320 330 340 350 360
EFGRRWQLIQ ESVVPNRFYW SVMGSSKEPD LVHLEARTVD GHSIYLTCRM QNCTEANRNK
370 380 390 400 410 420
PFPGYIDPDS LIVQDDYVFV QLTSGGRPHY YVSYRRSPFA QMKLPKYALP KDMHVISTDE
430 440 450 460 470 480
NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVRSSRG PEGNVMIDLY EVAGIKGMFL
490 500 510 520 530 540
ANKKIDNQVK TFITYNKGRD WRLLQAPDAD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI
550 560 570 580 590 600
IASRDTAPSI IVASGNIGSE LSDSDISMFV SSDAGNTWRQ IFEEEHSILY LDQGGVLVAM
610 620 630 640 650 660
KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL
670 680 690 700 710 720
VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQK YAGAMESEPC
730 740 750 760 770 780
VCTEADFDCD YGYERHSNGQ CLPAFWFNPS SLSKDCSLGQ SYLNSAGYRK VVSNNCTDGV
790 800 810 820 830 840
REQYTAKPQK CPGKAPRGLR IVTADGKLTA EQGHNVTLMV QLEEGDVQRT LIQVDFGDGI
850 860 870 880 890 900
AVSYVNLSSM EDGIKHVYQN VGIFRVTVQV DNSLGSDSAV LYLHVTCPLE HVHLSLPFVT
910 920 930 940 950 960
TKNKEVNATA VLWPSQVGTL TYVWWYGNNT EPLITLEGSI SFKFTSEGMN TITVQVSAGN
970 980 990 1000 1010 1020
AILQDTKTIA VYEEFRSLRL AFSPNLDDYN PDIPEWRRDI SRVIKKSLVE ATGIPSQHIL
1030 1040 1050 1060 1070 1080
VAVLPGLPTA AELFVLPYQD GTRENKRSPE DLEQISEVLI HKLNQNLVHF ELKPGVQVLV
1090 1100 1110 1120 1130 1140
HAAHLTAAPL VDLTPTHSGS AMLMLLSVVF VGLAVFVIYK FKRRVALPSP PSPSAQPGDS
1150 1160
SLRLQRPRPA TPPSSPKRGS AGAQFAI