Q9JL27
Gene name |
Fut2 |
Protein name |
Galactoside alpha-(1,2)-fucosyltransferase 2 |
Names |
Alpha(1,2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, Secretory blood group protein 2, Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2, Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14344 |
EC number |
2.4.1.69: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JL27
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JL27-F1 | Predicted | AlphaFoldDB |
33 variants for Q9JL27
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388907449 | 10 | F>L | No | EVA | |
| rs3388913299 | 24 | T>I | No | EVA | |
| rs52018600 | 31 | R>Q | No | EVA | |
| rs265256914 | 46 | V>I | No | EVA | |
| rs3388903525 | 49 | S>F | No | EVA | |
| rs237043086 | 49 | S>P | No | EVA | |
| rs218849040 | 51 | P>S | No | EVA | |
| rs260585829 | 57 | D>E | No | EVA | |
| rs3397617434 | 63 | K>T | No | EVA | |
| rs3398018003 | 65 | Q>H | No | EVA | |
| rs3397617399 | 66 | G>V | No | EVA | |
| rs3388911543 | 69 | T>M | No | EVA | |
| rs3397860814 | 89 | L>P | No | EVA | |
| rs3388906210 | 128 | W>* | No | EVA | |
| rs3388892393 | 145 | P>S | No | EVA | |
| rs237757933 | 165 | R>C | No | EVA | |
| rs3388911593 | 176 | D>G | No | EVA | |
| rs3388911347 | 179 | R>H | No | EVA | |
| rs3388911540 | 236 | A>G | No | EVA | |
| rs3388896671 | 245 | V>A | No | EVA | |
| rs3388907379 | 252 | W>* | No | EVA | |
| rs50491682 | 255 | E>K | No | EVA | |
| rs47300688 | 256 | N>S | No | EVA | |
| rs223092165 | 259 | T>A | No | EVA | |
| rs46174733 | 261 | L>R | No | EVA | |
| rs3388913340 | 270 | G>R | No | EVA | |
| rs3388906203 | 278 | D>G | No | EVA | |
| rs3388883289 | 305 | G>S | No | EVA | |
| rs3388911598 | 314 | T>S | No | EVA | |
| rs217014070 | 323 | I>V | No | EVA | |
| rs3388889790 | 331 | L>P | No | EVA | |
| rs217231038 | 333 | E>K | No | EVA | |
| rs3388889780 | 346 | K>M | No | EVA |
No associated diseases with Q9JL27
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.69 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-(1,2)-fucosyltransferase activity | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. |
| fucosyltransferase activity | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
| galactoside 2-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| fucosylation | The covalent attachment of a fucosyl group to an acceptor molecule. |
| glycolipid metabolic process | The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
| regulation of endothelial cell proliferation | Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q10017 | T25D10.1 | Uncharacterized protein T25D10.1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASAQVPFSF | PLAHFLIFVF | VTSTIIHLQQ | RIVKLQTLSE | KELQAVQMSS | PNAARTDMQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAKLQGIFTI | NSIGRLGNQM | GEYATLFALA | RMNGRLAFIP | ESMHNALAPI | FRISLPVLHS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DTARRIPWQN | YHLNDWMEER | YRHIPGQYVR | FTGYPCSWTF | YHHLRPEILK | EFTLHDHVRE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAQAFLRGLR | VNGSQPSTFV | GVHVRRGDYV | HVMPKVWKGV | VADRGYLEKA | LDRFRARYSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVFVVTSNGM | AWCRENINTS | LGDVVFAGNG | IEGSPAKDFA | LLTQCNHTIM | TIGTFGIWAA |
| 310 | 320 | 330 | 340 | ||
| YLAGGDTIYL | ANYTLPDSPF | LKIFKPAAAF | LPEWMGIPAD | LSPLLKH |