Q9JKX4

PR
Gene name
Aatf (Che1, Trb)
Protein name
Protein AATF
Names
Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, Traube protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:56321
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JKX4

Entry ID Method Resolution Chain Position Source
AF-Q9JKX4-F1 Predicted AlphaFoldDB

27 variants for Q9JKX4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs263706992 74 T>A No EVA
rs29406874 75 T>I No EVA
rs224180680 84 H>Q No EVA
rs29469402 86 E>K No EVA
rs232969182 88 A>T No EVA
rs229827964 97 A>V No EVA
rs29453055 128 K>E No EVA
rs29425227 146 E>Q No EVA
rs233623972 150 E>K No EVA
rs29442505 177 A>T No EVA
rs3389187210 181 S>N No EVA
rs3389189832 183 K>I No EVA
rs3389176588 205 L>S No EVA
rs215447135 239 A>S No EVA
rs3389185160 268 P>S No EVA
rs3389157538 288 S>C No EVA
rs3389157555 371 R>SE* No EVA
rs3389151535 372 L>WLR* No EVA
rs3389176573 374 R>G No EVA
rs28224212 382 A>T No EVA
rs3389124158 394 E>* No EVA
rs3389164153 412 A>S No EVA
rs3389188091 424 F>I No EVA
rs3389187751 460 I>L No EVA
rs3389187761 464 R>Q No EVA
rs217049543 468 R>C No EVA
rs3389203456 479 R>W No EVA

No associated diseases with Q9JKX4

2 regional properties for Q9JKX4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 39 - 49 IPR001412
domain RNA-binding S4 domain 353 - 415 IPR002942

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

3 GO annotations of molecular function

Name Definition
leucine zipper domain binding Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
tau protein binding Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.

13 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
embryonic cleavage The first few specialized divisions of an activated animal egg.
negative regulation of amyloid precursor protein biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
negative regulation of reactive oxygen species metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
negative regulation of superoxide anion generation Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NY61 AATF Protein AATF Homo sapiens (Human) PR
10 20 30 40 50 60
MAAPQPLALQ LEQLLNPRPR EADPEADPEE ATRARVIDRF DEGEEEKDDL AVSSIRKLAP
70 80 90 100 110 120
VSLLDTDKRY SGKTTSRKAW KEDHWEQALP SSSDNEASDE GGSEDGDSEG LGLEEISEDV
130 140 150 160 170 180
DEDLEDNKIS DEGGSEDGDS EGLGLEEFSE DVEEDLEGED EEDREEDRNS EDDGVVAAFS
190 200 210 220 230 240
SVKVSEEVEK GRAVKNQIAL WDQLLEGRIK LQKALLTTNQ LPQPDVFPVF KDKGGPEFAS
250 260 270 280 290 300
ALKNSHKALK ALLRSLVDLQ EELLFQYPDT RHIVNGAKPN TESEEISSED DELVGEKKKQ
310 320 330 340 350 360
RKAPPKRKLE MEDYPSFMAK RFADFTIYRN HTLQKWHDKT KLASGKLGKG FGAFERSILT
370 380 390 400 410 420
QIDHIMMDKE RLLRRTQTKR SAYRVLGKPE PVPEPVAETL PGEPETLPQG PANAHLRDLD
430 440 450 460 470 480
EEIFDDDDFY HQLLRELIER KTSSLDPNDQ VAMGRQWLAI QKLRSKIRKK VDRKASKGRK
490 500 510 520
LRFHVLSKLL SFMAPIDHTA MSDDARTELF RSLFGQLNPP DADRGK