Q9JKQ2

PR
Gene name
SLC26A5 (PRES)
Protein name
Prestin
Names
Solute carrier family 26 member 5
Species
Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9JKQ2

Entry ID Method Resolution Chain Position Source
7SUN EM 360 A A/B 1-744 PDB
AF-Q9JKQ2-F1 Predicted AlphaFoldDB

No variants for Q9JKQ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9JKQ2

No associated diseases with Q9JKQ2

3 regional properties for Q9JKQ2

Type Name Position InterPro Accession
domain STAS domain 525 - 713 IPR002645
domain SLC26A/SulP transporter domain 81 - 475 IPR011547
conserved_site Sulphate anion transporter, conserved site 109 - 130 IPR018045

Functions

Description
EC Number
Subcellular Localization
  • Lateral cell membrane ; Multi-pass membrane protein
  • Lateral cell membrane of outer hair cells (PubMed:11435925)
  • Alters profoundly the shape of its surrounding lipid bilayer (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
secondary active sulfate transmembrane transporter activity Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.

2 GO annotations of biological process

Name Definition
regulation of cell shape Any process that modulates the surface configuration of a cell.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDHAEENEIP VATQKYHVER PIFSHPVLQE RLHVKDKVSE SIGDKLKQAF TCTPKKIRNI
70 80 90 100 110 120
IYMFLPITKW LPAYKFKEYV LGDLVSGIST GVLQLPQGLA FAMLAAVPPV FGLYSSFYPV
130 140 150 160 170 180
IMYCFFGTSR HISIGPFAVI SLMIGGVAVR LVPDDIVIPG GVNATNGTEA RDALRVKVAM
190 200 210 220 230 240
SVTLLSGIIQ FCLGVCRFGF VAIYLTEPLV RGFTTAAAVH VFTSMLKYLF GVKTKRYSGI
250 260 270 280 290 300
FSVVYSTVAV LQNVKNLNVC SLGVGLMVFG LLLGGKEFNE RFKEKLPAPI PLEFFAVVMG
310 320 330 340 350 360
TGISAGFNLH ESYSVDVVGT LPLGLLPPAN PDTSLFHLVY VDAIAIAIVG FSVTISMAKT
370 380 390 400 410 420
LANKHGYQVD GNQELIALGI CNSIGSLFQT FSISCSLSRS LVQEGTGGKT QLAGCLASLM
430 440 450 460 470 480
ILLVILATGF LFESLPQAVL SAIVIVNLKG MFMQFSDLPF FWRTSKIELT IWLTTFVSSL
490 500 510 520 530 540
FLGLDYGLIT AVIIALLTVI YRTQSPSYKV LGQLPDTDVY IDIDAYEEVK EIPGIKIFQI
550 560 570 580 590 600
NAPIYYANSD LYSNALKRKT GVNPALIMGA RRKAMRKYAK EVGNANIANA AVVKVDGEVD
610 620 630 640 650 660
GENATKPEEE DDEVKYPPIV IKTTFPEELQ RFMPQTENVH TIILDFTQVN FIDSVGVKTL
670 680 690 700 710 720
AVMVKEYGDV GIYVYLAGCS PQVVNDLTRN RFFENPALKE LLFHSIHDAV LGSHVREAMA
730 740
EQEASAPPPQ DDMEPNATPT TPEA