Q9JIZ9
PR
Gene name |
Plscr3 |
Protein name |
Phospholipid scramblase 3 |
Names |
PL scramblase 3, Ca(2+)-dependent phospholipid scramblase 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70310 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JIZ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JIZ9-F1 | Predicted | AlphaFoldDB |
14 variants for Q9JIZ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3402358459 | 8 | K>T | No | EVA | |
| rs3401781763 | 18 | Y>S | No | EVA | |
| rs3389166399 | 37 | A>V | No | EVA | |
| rs3389178870 | 45 | A>D | No | EVA | |
| rs3389143398 | 74 | P>S | No | EVA | |
| rs3389170567 | 112 | G>E | No | EVA | |
| rs3401749566 | 135 | R>H | No | EVA | |
| rs3402276933 | 136 | R>Q | No | EVA | |
| rs3402538747 | 138 | F>L | No | EVA | |
| rs3389170875 | 176 | P>T | No | EVA | |
| rs3389135267 | 217 | C>Y | No | EVA | |
| rs3389170694 | 233 | S>R | No | EVA | |
| rs3389168868 | 239 | K>R | No | EVA | |
| rs26908192 | 294 | I>V | No | EVA |
No associated diseases with Q9JIZ9
No regional properties for Q9JIZ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9JIZ9 | |||
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| lead ion binding | Binding to lead (Pb) ions. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| mercury ion binding | Binding to a mercury ion (Hg). |
| phospholipid scramblase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. |
| protein self-association | Binding to a domain within the same polypeptide. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cardiolipin biosynthetic process | The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| cholesterol homeostasis | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| plasma membrane phospholipid scrambling | The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of release of cytochrome c from mitochondria | Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NRY6 | PLSCR3 | Phospholipid scramblase 3 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGYLPPKGY | APSPPPPYPV | PSGYPEPVAL | HPGPGQAPVP | TQVPAPAPGF | ALFPSPGPVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGPPAPFVPL | PGVPPGLEFL | VQIDQILIHQ | KAERVETFLG | WETCNMYELR | SGTGQQLGQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEESNCCARL | CCGARRPFRI | RLADPGDREV | LRLLRPLHCG | CSCCPCGLQE | MEVQAPPGTT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IGHVLQTWHP | FLPKFSILDA | DRQPVLRVVG | PCWTCGCGTD | TNFEVKTKDE | SRSVGRISKQ |
| 250 | 260 | 270 | 280 | 290 | |
| WGGLLREALT | DADDFGLQFP | VDLDVKVKAV | LLGATFLIDY | MFFEKRGGAG | PSAITS |