Q9JIT0
Gene name |
Lmbr1 |
Protein name |
Limb region 1 protein |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56873 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JIT0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JIT0-F1 | Predicted | AlphaFoldDB |
15 variants for Q9JIT0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs581025228 | 16 | S>C | No | EVA | |
| rs3388750455 | 16 | S>I | No | EVA | |
| rs3388735946 | 30 | I>N | No | EVA | |
| rs3388723565 | 53 | D>N | No | EVA | |
| rs3388741969 | 70 | V>L | No | EVA | |
| rs6303637 | 93 | H>Q | No | EVA | |
| rs218552504 | 94 | N>S | No | EVA | |
| rs3388750632 | 123 | L>S | No | EVA | |
| rs3395156354 | 137 | A>S | No | EVA | |
| rs259194070 | 161 | I>L | No | EVA | |
| rs3388743074 | 192 | Y>F | No | EVA | |
| rs3388746575 | 271 | N>S | No | EVA | |
| rs3388750380 | 362 | S>Y | No | EVA | |
| rs3388743115 | 472 | T>I | No | EVA | |
| rs3388749037 | 487 | Q>H | No | EVA |
No associated diseases with Q9JIT0
No regional properties for Q9JIT0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9JIT0 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| embryonic digit morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. |
| embryonic hindlimb morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WVP7 | LMBR1 | Limb region 1 protein homolog | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGQDEVSAR | EQHFHSQVRE | STICFLLFAI | LYIVSYFIII | RYKRKSDEQE | DEDAVVNRIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFLSTFTLAV | SAGAVLLLPF | SIISNEILLA | FPHNYYIQWL | NGSLIHGLWN | LASLFSNLCL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FVLMPFAFFF | LESEGFAGLK | KGIRARILET | LVMLLLLALL | ILGMVWVASA | LIDSDAASME |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLYDLWEFYL | PYLYSCISLM | GCLLLLLCTP | VGLSRMFTVM | GQLLVKPAIL | EDLDEQIYMI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLEEEALQRR | LHGLSSSVEY | NVMELEQELE | NVKILKTKLE | RRKKASAWER | NLVYPAVMVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLIETSISVL | LVACNILCLL | VDETAMPKGT | RGPGIGSASL | STFGFVGAAL | EIILIFYLMV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSVVGFYSLR | FFGNFTPKKD | DTTMTKIIGN | CVSILVLSSA | LPVMSRTLGI | TRFDLLGDFG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RFNWLGNFYI | VLSYNLLFAI | MTTLCLIRKF | TSAVREELFK | ALGLHKLHLS | DTSRDSETTK |
| PSANGHQKAL |