AiPD: Autoinhibited Protein Database

Gene name	Slc15a1
Protein name	Solute carrier family 15 member 1
Names	Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, Peptide transporter 1, Proton-coupled dipeptide cotransporter
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:56643
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

660-709 (Predicted disordered autoinhibitory region) PR

660-709 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5A9D	X-ray	210 A	A/B	391-579	PDB
AF-Q9JIP7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs1133546254	4	S>F	No	EVA
rs3389342867	10	F>Y	No	EVA
rs3389354701	21	V>I	No	EVA
rs45659504	50	N>D	No	EVA
rs3405466053	65	L>Q	No	EVA
rs3389350177	66	T>S	No	EVA
rs3406052333	68	I>S	No	EVA
rs3404918006	69	L>I	No	EVA
rs3389342870	90	V>F	No	EVA
rs3405820638	101	S>R	No	EVA
rs3404259495	105	D>E	No	EVA
rs3389359544	112	N>I	No	EVA
rs3389344065	118	L>H	No	EVA
rs230063489	127	V>I	No	EVA
rs3389354759	145	A>T	No	EVA
rs3389339272	145	A>V	No	EVA
rs3389300944	169	A>D	No	EVA
rs3389350179	173	G>E	No	EVA
rs246030141	235	K>R	No	EVA
rs3389339290	261	W>R	No	EVA
rs3389345700	289	P>S	No	EVA
rs3405819261	299	Q>LTSS*	No	EVA
rs3389342862	314	K>I	No	EVA
rs3389350229	321	Q>H	No	EVA
rs3389320088	326	Q>P	No	EVA
rs3389350199	404	N>I	No	EVA
rs1132355378	405	N>S	No	EVA
rs3389320079	450	T>I	No	EVA
rs3405819298	453	H>Q	No	EVA
rs3405254151	454	D>N	No	EVA
rs3404988053	455	F>L	No	EVA
rs3404259500	455	F>Y	No	EVA
rs3405465006	463	L>*	No	EVA
rs3389339300	477	G>D	No	EVA
rs3389271568	477	G>S	No	EVA
rs3405759889	484	K>R	No	EVA
rs3389300923	501	I>V	No	EVA
rs3389351932	507	V>I	No	EVA
rs3389347601	510	N>I	No	EVA
rs8255954	526	E>K	No	EVA
rs3389271537	532	N>K	No	EVA
rs239860901	535	A>E	No	EVA
rs3389354776	538	P>L	No	EVA
rs219031338	539	T>N	No	EVA
rs248399080	545	K>E	No	EVA
rs232389072	562	A>T	No	EVA
rs8245291	562	A>V	No	EVA
rs3389350168	618	V>M	No	EVA
rs240403848	640	A>G	No	EVA
rs8255946	664	F>L	No	EVA
rs3389339320	676	P>S	No	EVA
rs3389271506	693	G>E	No	EVA

Type	Name	Position	InterPro Accession
domain	Neutral trehalase Ca2+ binding	106 - 135	IPR011120
conserved_site	Glycoside hydrolase, family 37, conserved site	299 - 312	IPR018232-1
conserved_site	Glycoside hydrolase, family 37, conserved site	623 - 632	IPR018232-2

		Description
EC Number
Subcellular Localization	Apical cell membrane ; Multi-pass membrane protein	Localized to the apical membrane of enterocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
brush border	The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a channel.
dipeptide transmembrane transporter activity	Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.
peptide:proton symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.
proton-dependent oligopeptide secondary active transmembrane transporter activity	Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.

Name	Definition
dipeptide import across plasma membrane	The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.
negative regulation of amino acid transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
oligopeptide transport	The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P46059	SLC15A1	Solute carrier family 15 member 1	Homo sapiens (Human)	PR
Q3E9B5	NPF7.1	Protein NRT1/ PTR FAMILY 7.1	Arabidopsis thaliana (Mouse-ear cress)	PR