Q9JII5

PR
Gene name
Dazap1
Protein name
DAZ-associated protein 1
Names
Deleted in azoospermia-associated protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:70248
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

308-382 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JII5

Entry ID Method Resolution Chain Position Source
AF-Q9JII5-F1 Predicted AlphaFoldDB

16 variants for Q9JII5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389109487 11 K>R No EVA
rs3389109412 18 D>E No EVA
rs3389079141 61 P>L No EVA
rs3389123638 80 I>N No EVA
rs3389106540 83 K>M No EVA
rs3389090970 92 P>L No EVA
rs3389117114 106 R>T No EVA
rs3389087877 112 S>F No EVA
rs3389106500 162 E>D No EVA
rs3389113601 205 Q>* No EVA
rs3389112746 236 W>R No EVA
rs3389123619 241 Q>* No EVA
rs3389056557 256 P>S No EVA
rs3389112745 257 P>L No EVA
rs3389056634 258 P>S No EVA
rs3389106530 314 A>P No EVA

No associated diseases with Q9JII5

4 regional properties for Q9JII5

Type Name Position InterPro Accession
domain RNA recognition motif domain 10 - 97 IPR000504-1
domain RNA recognition motif domain 113 - 190 IPR000504-2
domain DAZ-associated protein 1, RNA recognition motif 2 111 - 190 IPR034131
domain DAZ-associated protein 1, RNA recognition motif 1 11 - 92 IPR034134

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Predominantly cytoplasmic
  • Nuclear at some stages of spermatozoides development
  • In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles
  • In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
male germ cell nucleus The nucleus of a male germ cell, a reproductive cell in males.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

6 GO annotations of molecular function

Name Definition
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
poly(G) binding Binding to a sequence of guanine residues in an RNA molecule.
poly(U) RNA binding Binding to a sequence of uracil residues in an RNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA stem-loop binding Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.

5 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
fibroblast proliferation The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.
maternal placenta development Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
positive regulation of mRNA splicing, via spliceosome Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96EP5 DAZAP1 DAZ-associated protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MNSAGADEIG KLFVGGLDWS TTQETLRSYF SQYGEVVDCV IMKDKTTNQS RGFGFVKFKD
70 80 90 100 110 120
PNCVGTVLAS RPHTLDGRNI DPKPCTPRGM QPERTRPKEG WQKGPRSDSS KSNKIFVGGI
130 140 150 160 170 180
PHNCGETELR EYFKKFGVVT EVVMIYDAEK QRPRGFGFIT FEDEQSVDQA VNMHFHDIMG
190 200 210 220 230 240
KKVEVKRAEP RDSKNQAPGQ PGASQWGSRV APSAANGWAG QPPPTWQQGY GPQGMWVPAG
250 260 270 280 290 300
QAIGGYGPPP AGRGAPPPPP PFTSYIVSTP PGGFPPPQGF PQGYGAPPQF SFGYGPPPPP
310 320 330 340 350 360
PDQFAPPGVP PPPATPGAAP LAFPPPPSQA APDMSKPPTA QPDFPYGQYG YGQDLSGFGQ
370 380 390 400
GFSDPSQQPP SYGGPSVPGS GGPPAGGSGF GRGQNHNVQG FHPYRR