Q9JIG7
Gene name |
Ccdc22 (DXImx40e) |
Protein name |
Coiled-coil domain-containing protein 22 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54638 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JIG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JIG7-F1 | Predicted | AlphaFoldDB |
43 variants for Q9JIG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3409544957 | 9 | I>T | No | EVA | |
| rs3389458108 | 10 | H>L | No | EVA | |
| rs3389545225 | 41 | C>G | No | EVA | |
| rs3410006852 | 70 | S>T | No | EVA | |
| rs3389458129 | 98 | R>* | No | EVA | |
| rs3389566007 | 103 | F>L | No | EVA | |
| rs3389506266 | 104 | L>M | No | EVA | |
| rs3412796790 | 107 | R>L | No | EVA | |
| rs3389518105 | 112 | A>T | No | EVA | |
| rs3389554925 | 149 | T>A | No | EVA | |
| rs33357812 | 181 | W>R | No | EVA | |
| rs3389562581 | 191 | P>S | No | EVA | |
| rs3389551199 | 213 | Q>* | No | EVA | |
| rs3409455079 | 230 | R>H | No | EVA | |
| rs3389498004 | 263 | L>F | No | EVA | |
| rs3410006904 | 263 | L>P | No | EVA | |
| rs3409327335 | 305 | P>S | No | EVA | |
| rs258924840 | 312 | V>L | No | EVA | |
| rs3408355025 | 320 | Q>P* | No | EVA | |
| rs3409514160 | 321 | R>S | No | EVA | |
| rs33355834 | 322 | L>P | No | EVA | |
| rs3409115096 | 323 | E>* | No | EVA | |
| rs3409327375 | 323 | E>G | No | EVA | |
| rs3409455026 | 324 | Q>E | No | EVA | |
| rs3409414489 | 325 | D>A | No | EVA | |
| rs3389506335 | 341 | L>M | No | EVA | |
| rs3389545278 | 344 | V>E | No | EVA | |
| rs3409455081 | 354 | D>A | No | EVA | |
| rs3389518114 | 362 | L>I | No | EVA | |
| rs3408793043 | 379 | Q>L | No | EVA | |
| rs3409543560 | 417 | L>S* | No | EVA | |
| rs3409414448 | 418 | A>G | No | EVA | |
| rs3389497927 | 469 | R>L | No | EVA | |
| rs3389551777 | 480 | E>V | No | EVA | |
| rs3389551274 | 494 | T>I | No | EVA | |
| rs3389551274 | 494 | T>S | No | EVA | |
| rs3389458079 | 509 | E>G | No | EVA | |
| rs3408431971 | 517 | D>G | No | EVA | |
| rs3408432057 | 542 | L>P | No | EVA | |
| rs3389529235 | 577 | T>I | No | EVA | |
| rs3389551259 | 597 | K>M | No | EVA | |
| rs3409414476 | 614 | R>L | No | EVA | |
| rs3408355018 | 616 | E>V | No | EVA |
No associated diseases with Q9JIG7
No regional properties for Q9JIG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9JIG7 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cullin family protein binding | Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular copper ion homeostasis | Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. |
| cholesterol homeostasis | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. |
| cytoplasmic sequestering of NF-kappaB | The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. |
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| Golgi to plasma membrane transport | The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. |
| negative regulation of I-kappaB kinase/NF-kappaB signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
| positive regulation of I-kappaB kinase/NF-kappaB signaling | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| positive regulation of ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of plasma lipoprotein particle levels | Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEADRILIH | SLRQAGTAVP | PEVQTLRAFT | TELVVEAVVR | CLRVINPDVG | SGLSHLLPPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MSARFRLAMS | LAQACMDLGY | PLELGYQNFL | YPSEPDLRDL | LLFLAERLPS | DASEDADQPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GDSAIFLRAI | GSQIRDQLAL | PWVPPLLRTP | KVQRLQGSAL | QQPFHSSRLV | LPELNSSGEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WEFQASPLLL | PAPTQVPQLQ | GRAASLLEHH | ASQLCQHVNR | DCPGDEDRVR | WASRVPSQED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRAPQQRLHK | QLIEHLRQSW | GPLGAPTQVR | DLGEMLQTWG | ARAMTGVPKG | SRFTHSEKFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FHLEPQVQAA | QVADVPATSQ | RLEQDTRAAQ | EQELESLREQ | LASVNHNIEE | VEADMKTLGI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLVQVETECR | QSELSVAEQE | QALRLKSRTV | ELLPDGAANL | AKLQLVVESS | AQRLIHLASQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WEKHRVPLLA | EYRHLRRLQD | CRELESSRRL | AEIQELHHSV | RAAAEEARRK | EEVYKQLVSE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LETLPKDVSR | LAYTQRILEI | VGNIRKQKEE | ITKILSDTKE | LQKEINSLSG | KLDRTFAVTD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELVFKDAKKD | DAVRKAYKYL | AALHENCSQL | IQTIEDTGTI | MREVRDLEEQ | IETEMGKKTL |
| 610 | 620 | ||||
| SNLEKICEDY | RALRQENAGL | LGRVREA |