Q9JHE4
Gene name |
Gal3st1 |
Protein name |
Galactosylceramide sulfotransferase |
Names |
GalCer sulfotransferase, 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase, 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase, Cerebroside sulfotransferase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53897 |
EC number |
2.8.2.11: Sulfotransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JHE4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JHE4-F1 | Predicted | AlphaFoldDB |
14 variants for Q9JHE4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389115649 | 34 | V>I | No | EVA | |
| rs226979448 | 55 | I>V | No | EVA | |
| rs3389136605 | 82 | K>R | No | EVA | |
| rs3389148798 | 100 | Q>* | No | EVA | |
| rs3389148794 | 142 | M>T | No | EVA | |
| rs3389138056 | 143 | R>H | No | EVA | |
| rs3389127021 | 145 | H>L | No | EVA | |
| rs3389103715 | 147 | E>V | No | EVA | |
| rs3389138095 | 153 | V>L | No | EVA | |
| rs3389138066 | 161 | T>S | No | EVA | |
| rs3401895802 | 321 | A>D | No | EVA | |
| rs244003552 | 343 | H>R | No | EVA | |
| rs3389077369 | 353 | G>R | No | EVA | |
| rs1134686937 | 363 | Q>* | No | EVA |
No associated diseases with Q9JHE4
No regional properties for Q9JHE4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9JHE4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.8.2.11 | Sulfotransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| galactose 3-O-sulfotransferase activity | Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. |
| galactosylceramide sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. |
| sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| galactosylceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. |
| galactosylceramide metabolic process | The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. |
| glycerolipid metabolic process | The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. |
| glycolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| sphingolipid metabolic process | The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLLPKKPCK | SKAKGLLLGA | LFTSFLLLLY | SYVVPPLYPN | MAFTTSEAAA | PCSPIPNEPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AATPANGSAG | GCQPRRDIVF | MKTHKTASST | LLNILFRFGQ | KHELKFAFPN | GRNDFHYPSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FARSLVQDYR | PGACFNIICN | HMRFHYEEVR | GLVRPGATFI | TVIRDPARLF | ESSFHYFGSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPLTWKLSSR | DKLAEFLQDP | DRYYDPSSYN | AHYLRNLLFF | DLGYDSSLDP | ASPRVQEHIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVERRFHLVL | LQEYFDESLV | LLRELLCWDL | EDVLYFKLNA | RRDSPVPRLS | GELYRRATAW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLLDVRLYRH | FNASFWRKVE | AFGRERMARE | VAELRQANEH | MRHICIDGGQ | AVGAEAIQDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AMQPWQPLGI | KSILGYNLKK | SIGPQHEQLC | RRMLTPEIQY | LSDLGANLWV | TKLWKFLRDF |
| LRW |