Q9JH66

PR
Gene name
ORF1
Protein name
Non-structural polyprotein 1AB
Names
Species
Ovine astrovirus 1 (OAstV-1)
KEGG Pathway
vg:1449587
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

608-683 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q9JH66

Entry ID Method Resolution Chain Position Source

No variants for Q9JH66

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9JH66

No associated diseases with Q9JH66

2 regional properties for Q9JH66

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, C-terminal domain 938 - 1266 IPR001205
domain RNA-directed RNA polymerase, catalytic domain 1085 - 1217 IPR007094

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • Host membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell membrane Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNVYDKVLQF GSKKARARGM ALNKLSRNRL EDIYAGSGPL VFGFGPIDMV DPGSLNPSIK
70 80 90 100 110 120
TLDTVYVAAV QPDNQYVVHH FVPGRNEWVE TDASTHQPTA LVGVLVQDHK AKTREVEDLK
130 140 150 160 170 180
SQLSQLRMEH EILRHEYERL KLKSPIVKPF KPLKVLLFSL LLGLLFAGVT NGARTGTCYA
190 200 210 220 230 240
YDEEKDTCLY WEWKDSREVA WYDSYVTEAL AIYNRACVYV RSKEFMTYLS LVFQTVFNWY
250 260 270 280 290 300
FCATALAVYY MARAENPIVM FVTLALATLS QFQLLAVAVL PLLDFSATMG LWLSMVVFYM
310 320 330 340 350 360
SQQISILVSF CVLVLSVMIG TFMADSEYAM MIKGHAVVFA IVCYSHVAMI LNIPPWVVSL
370 380 390 400 410 420
TMVCYRLWRV CFVFPAERLE IRSADGKVLH TVPTHPNWTA KVTRFVQSLR KGLRTSVAPT
430 440 450 460 470 480
ARIVPDGIAI VEAREGVGTC FRVKNNLVTS KHVVGSDDAV KIRWGAQEDM ARVTYRHPTK
490 500 510 520 530 540
DIALMALPTN LQTMPAYKFA KAITDGPIVM TAFDEANLLL VAVTEGVRVE DHMTYSVATR
550 560 570 580 590 600
NGMSGAPITT VDGRVIAVHQ TNTGFTGGAV IFVPEDIPEV RKISKREQEL EDRVKQLEGM
610 620 630 640 650 660
LNMDQAYVDS NLIVDLVREA VQREMKVLRT ELANLGGFSQ KKKGKNKSTK RKRKAVWTEE
670 680 690 700 710 720
EYKAMLEKGF TRDQLRIMAD AIRDQYYDDE DEQSEEEAGY PDWSDPGDST DIENEWFGYE
730 740 750 760 770 780
QSWKELEPAK SGVVVNTLPK DLVFKYSLDN YPISKQDIQA VAKELKIYEK AISDIISTSV
790 800 810 820 830 840
STDGKWKDDV DAQKILQELD GLWWGINHTL WEHGLMPFTQ RRKRVQQPKK LQRGPEDPGP
850 860 870 880 890 900
EECKLDYWEQ LVEPSKEKFL VPPEYPLLGV VPLDRPISDF DAPVDNLLAL LPEPESPDLG
910 920 930 940 950 960
FEPAVWGPEA YVKSFEKFDF ADPDPNIEKN YPREWAFANL VLHREFDFLA DSVVKDITAT
970 980 990 1000 1010 1020
SKNSESTPGF PKTYWWKTEA EYLAKRGYAD YVSEWNRIRG GARPNVLWYL FLKKEILKST
1030 1040 1050 1060 1070 1080
KVRDADIRQI ICSDPIFARI GCCFEEDQNE RMKRRTKTRM PQCGWSPFFG GFNDRIQRLV
1090 1100 1110 1120 1130 1140
AKGNPYWIEF DWTRYDGTIP SQIFKHIKNF RFSMLAKEYQ TPELRNMYHW YVDNILRRYV
1150 1160 1170 1180 1190 1200
CMPSGEITIQ HKGNPSGQVS TTMDNNLVNV FLQAFEYAYL HPEKSMDELR KDWESYDSLI
1210 1220 1230 1240 1250 1260
YGDDRLTTSP SVPNDYVTRV VAMYKDIFGM WVKPEKVKVS HSPVGLSFCG FVITHQDGQY
1270 1280 1290 1300 1310 1320
LPVPAEEAKL LASLLRPTKK LENMDALYGK LLCYRILNHN LPNDNKFRNY ILVALEVMAR
1330 1340 1350
HYSSRGEEPP FYVTESMLDK LWRGGPKFDY G