Q9IMP5

PR
Gene name
PA
Protein name
Polymerase acidic protein
Names
RNA-directed RNA polymerase subunit P2
Species
Influenza C virus (strain C/Johannesburg/1/1966)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-280 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for Q9IMP5

Entry ID Method Resolution Chain Position Source
5D98 X-ray 390 A A/D 1-709 PDB
5D9A X-ray 430 A A/D/G/J 1-709 PDB
6F5P X-ray 414 A A/D 1-709 PDB
6XZD EM 340 A AP1/DP1 1-709 PDB
6XZG EM 380 A AP1/DP1 1-709 PDB
6XZP EM 330 A AP1/DP1 1-709 PDB
6XZQ EM 360 A A/D 1-709 PDB
6XZR EM 330 A AP1/DP1 1-709 PDB
6Y0C EM 320 A A 1-709 PDB

No variants for Q9IMP5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9IMP5

No associated diseases with Q9IMP5

No regional properties for Q9IMP5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9IMP5

Functions

Description
EC Number
Subcellular Localization
  • Host cytoplasm
  • Host nucleus
  • PB1 and PA are transported in the host nucleus as a complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

3 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKTFAEIAE AFLEPEAVRI AKEAVEEYGD HERKIIQIGI HFQVCCMFCD EYLSTNGSDR
70 80 90 100 110 120
FVLIEGRKRG TAVSLQNELC KSYDLEPLPF LCDIFDREEK QFVEIGITRK ADDSYFQSKF
130 140 150 160 170 180
GKLGNSCKIF VFSYDGRLDK NCEGPMEEQK LRIFSFLATA ADFLRKENMF NEIFLPDNEE
190 200 210 220 230 240
TIIEMKKGKT FLELRDESVP LPFQTYEQMK DYCEKFKGNP RELASKVSQM QSNIKLPIKH
250 260 270 280 290 300
YEQNKFRQIR LPKGPMAPYT HKFLMEEAWM FTKISDPERS RAGEILIDFF KKGNLSAIRP
310 320 330 340 350 360
KDKPLQGKYP IHYKNLWNQI KAAIADRTMV INENDHSEFL GGIGRASKKI PEISLTQDVI
370 380 390 400 410 420
TTEGLKQSEN KLPEPRSFPR WFNAEWMWAI KDSDLTGWVP MAEYPPADNE LEDYAEHLNK
430 440 450 460 470 480
TMEGVLQGTN CAREMGKCIL TVGALMTECR LFPGKIKVVP IYARSKERKS MQEGLPVPSE
490 500 510 520 530 540
MDCLFGICVK SKSHLNKDDG MYTIITFEFS IREPNLEKHQ KYTVFEAGHT TVRMKKGESV
550 560 570 580 590 600
IGREVPLYLY CRTTALSKIK NDWLSKARRC FITTMDTVET ICLRESAKAE ENLVEKTLNE
610 620 630 640 650 660
KQMWIGKKNG ELIAQPLREA LRVQLVQQFY FCIYNDSQLE GFCNEQKKIL MALEGDKKNK
670 680 690 700
SSFGFNPEGL LEKIEECLIN NPMCLFMAQR LNELVIEASK RGAKFFKTD