Q9IAX6

PR
Gene name
Protein name
Zinc metalloproteinase/disintegrin
Names
Species
Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

111-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9IAX6

Entry ID Method Resolution Chain Position Source
AF-Q9IAX6-F1 Predicted AlphaFoldDB

No variants for Q9IAX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9IAX6

No associated diseases with Q9IAX6

4 regional properties for Q9IAX6

Type Name Position InterPro Accession
domain Peptidase M12B, ADAM/reprolysin 180 - 377 IPR001590
domain Disintegrin domain 385 - 466 IPR001762
domain Peptidase M12B, propeptide 34 - 139 IPR002870
domain Reprolysin domain, adamalysin-type 180 - 375 IPR034027

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
FPYQGSSIIL ESGNVNDYEV VYPRKVTALP KGAVQQKYED TMQYEFKVNG EPVVLHLEKN
70 80 90 100 110 120
KGLFSKDYSE THYSPDGRRI TTHPLVEDHC YYRGRIRNDA DSTASISACN GLKGHFKLRG
130 140 150 160 170 180
ETYLIEPMKI SNSEAHAVYK YENVEKEDEA HKMCGVTQNW ESYEPIKKAS QLIVTPEHQR
190 200 210 220 230 240
YMEIVIVVDH SMYTKYNGDS DKIKTWIYEM SNTIRESYRY LYIDTSVAAI EIWSEKDLIN
250 260 270 280 290 300
VETSAKNTLE SFGEWRARDL IHRISHDNAQ LLTATDLDGP TIGLAYVASM CDPKRSVGVV
310 320 330 340 350 360
QDHSSVNHLV AITLAHEIAH NLGVRHDEGS CSCGSGYTCI MSPVINPDAM KYFSDCSYIQ
370 380 390 400 410 420
CWDYIMKENP PCILNKPLRT DTVSTPVSGN ELLEAGKDYD RDSSANPCYD AATCKLNQGA
430 440 450 460
QCTAGPCCDQ GRFKEEGTIC RRARGDDLDD YCNGISGDCP RNPYHA