Q9I8H0
Gene name |
six1 |
Protein name |
Homeobox protein six1 |
Names |
Sine oculis homeobox homolog 1 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:398185 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9I8H0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9I8H0-F1 | Predicted | AlphaFoldDB |
No variants for Q9I8H0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9I8H0 | |||||
No associated diseases with Q9I8H0
No regional properties for Q9I8H0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9I8H0 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSMLPSFGFT | QEQVACVCEV | LQQGGNLERL | GRFLWSLPAC | DHLHKNESVL | KAKAVVAFHR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GNFRELYKIL | ESHQFSPHNH | PKLQQLWLKA | HYVEAEKLRG | RPLGAVGKYR | VRRKFPLPRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IWDGEETSYC | FKEKSRGVLR | EWYAHNPYPS | PREKRELAEA | TGLTTTQVSN | WFKNRRQRDR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAEAKERENT | ENNNTSTNKQ | NQLSPLDGGK | SLMSSSEEEF | SPPQSPDQNS | VLLLQGSLTH |
| 250 | 260 | 270 | 280 | ||
| PGATSYSLSA | LSASQGSHGL | QGHQHQLQDS | LLGPLTSSLV | DLGS |