Q9I7S8

PR
Gene name
Paics
Protein name
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Names
PAICS, Protein adenosine-5
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3989
EC number
4.1.1.21: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

385-429 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9I7S8

Entry ID Method Resolution Chain Position Source
AF-Q9I7S8-F1 Predicted AlphaFoldDB

No variants for Q9I7S8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9I7S8

No associated diseases with Q9I7S8

4 regional properties for Q9I7S8

Type Name Position InterPro Accession
domain PurE domain 269 - 423 IPR000031
conserved_site SAICAR synthetase, conserved site 98 - 112 IPR018236
domain SAICAR synthetase/ADE2, N-terminal 15 - 328 IPR028923
domain Class II PurE 269 - 424 IPR033626

Functions

Description
EC Number 4.1.1.21 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
5-amino-4-imidazole carboxylate lyase activity Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosylaminoimidazole carboxylase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22234 PAICS Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase Homo sapiens (Human) PR
Q9DCL9 Paics Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase Mus musculus (Mouse) PR
10 20 30 40 50 60
MSTTTTASIE GYKLGKVIIE GKTKQVYDLP EQPGLCLLLS KDRITAGDGV KAHDLAGKAE
70 80 90 100 110 120
ISNTTNGQVF RLLNEAGIRT AYVKQCGAKA FIARKCQMIP IEWVTRRLAT GSFLKRNVGV
130 140 150 160 170 180
PEGYRFSPPK QETFFKDDAN HDPQWSEEQI VSAKFELNGL VIGQDEVDIM RRTTLLVFEI
190 200 210 220 230 240
LERAWQTKNC ALIDMKVEFG ICDDGNIVLA DIIDSDSWRL WPAGDKRLMV DKQVYRNLAS
250 260 270 280 290 300
VTASDLDTVK RNFIWVAEQL ADIVPKKDHL VVILMGSASD ISHSEKIATS CRSLGLNVEL
310 320 330 340 350 360
RVSSAHKGPE ETLRIVREYE SVMSNLIFVA VAGRSNGLGP VVSGSTNYPV INCPPVKSDN
370 380 390 400 410 420
MQVDVWSSLN LPSGLGCATV LYPEAAALHA ATILGLGNFM VWSKLRVKAL NNFITLKKAD
KELRGVRNA