Q9I7C2

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA0004
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

304-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q9I7C2

Entry ID Method Resolution Chain Position Source
6M1J X-ray 170 A A/B 17-221 PDB
6M1S X-ray 225 A A/B 17-221 PDB
7PTF X-ray 132 A A/B/C 1-221 PDB
7PTG X-ray 220 A A/B 1-221 PDB
8BN6 X-ray 160 A A 1-221 PDB
AF-Q9I7C2-F1 Predicted AlphaFoldDB

No variants for Q9I7C2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9I7C2

No associated diseases with Q9I7C2

7 regional properties for Q9I7C2

Type Name Position InterPro Accession
domain DNA gyrase B subunit, C-terminal 734 - 795 IPR002288
domain Histidine kinase/HSP90-like ATPase 33 - 177 IPR003594
domain TOPRIM domain 420 - 535 IPR006171
domain DNA topoisomerase, type IIA, subunit B, domain 2 222 - 392 IPR013506
conserved_site DNA topoisomerase, type IIA, conserved site 424 - 432 IPR018522
domain DNA gyrase subunit B, TOPRIM domain 420 - 534 IPR034160
domain DNA gyrase subunit B insert domain 566 - 732 IPR041423

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSENNTYDSS SIKVLKGLDA VRKRPGMYIG DTDDGTGLHH MVFEVVDNSI DEALAGYCSE
70 80 90 100 110 120
ISITIHTDES ITVRDNGRGI PVDIHKEEGV SAAEVIMTVL HAGGKFDDNT YKVSGGLHGV
130 140 150 160 170 180
GVSVVNALSH ELRLTIRRHN KVWEQVYHHG VPQFPLREVG ETDGSGTEVH FKPSPETFSN
190 200 210 220 230 240
IHFSWDILAK RIRELSFLNS GVGILLRDER TGKEELFKYE GGLKAFVEYL NTNKTAVNEV
250 260 270 280 290 300
FHFNVQREED GVGVEVALQW NDSFNENLLC FTNNIPQRDG GTHLAGFRSA LTRNLNNYIE
310 320 330 340 350 360
AEGLAKKFKI ATTGDDAREG LTAIISVKVP DPKFSSQTKD KLVSSEVKTA VEQEMGKYFA
370 380 390 400 410 420
DFLLENPNEA KAVVGKMIDA ARAREAARKA REMTRRKGAL DIAGLPGKLA DCQEKDPALS
430 440 450 460 470 480
ELYIVEGDSA GGSAKQGRNR RTQAILPLKG KILNVEKARF DKMLSSQEVG TLITALGCGI
490 500 510 520 530 540
GREEYNIDKL RYHNIIIMTD ADVDGSHIRT LLLTFFFRQM PELIERGYIY IAQPPLYKVK
550 560 570 580 590 600
RGKQEQYIKD DQAMEEYMTQ SALEDASLHV NEHAPGLSGA ALEKLVNEYR GVIATLKRLS
610 620 630 640 650 660
RLYPQELTEH FIYLPTVSVD DLANESAMQG WLEKFQARLT AAEKSGLTYK ASLREDRERH
670 680 690 700 710 720
LWLPEVELVA HGLSSYVTFN RDFFASNDYR SVSLLGDQLN SLLEDGAYVQ KGERKRPISA
730 740 750 760 770 780
FKDGLDWLMA EGTKRHSIQR YKGLGEMNPE QLWETTMDPN VRRMLKVTIE DAIAADQIFN
790 800
TLMGDAVEPR RDFIESNALA VSNLDV