Q9I6Z2

PR
Gene name
ahpF (PA0140)
Protein name
Alkyl hydroperoxide reductase subunit F
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA0140
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9I6Z2

Entry ID Method Resolution Chain Position Source
AF-Q9I6Z2-F1 Predicted AlphaFoldDB

No variants for Q9I6Z2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9I6Z2

No associated diseases with Q9I6Z2

5 regional properties for Q9I6Z2

Type Name Position InterPro Accession
active_site Pyridine nucleotide-disulphide oxidoreductase, class-II, active site 344 - 364 IPR008255
domain Thioredoxin-like fold 124 - 192 IPR012336
domain FAD/NAD(P)-binding domain 212 - 503 IPR023753
domain AhpF, N-terminal domain, C-terminal TRX-fold subdomain 105 - 193 IPR044141
domain AhpF, N-terminal domain, N-terminal TRX-fold subdomain 1 - 94 IPR044142

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
alkyl hydroperoxide reductase activity Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
thioredoxin-disulfide reductase activity Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.

2 GO annotations of biological process

Name Definition
cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell.
response to reactive oxygen species Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDANLKTQL KAYLEKVSQP FEIVASLDDS DKSRELLGLL QDIVGLTDKI TLKTDGSDAR
70 80 90 100 110 120
KPSFSLNRPG ADIGLRFAGI PMGHEFTSLV LALLQVGGHP SKLDADVIEQ VKGIEGTFEF
130 140 150 160 170 180
ETYFSLSCQN CPDVVQALNL MAVLNPNIRH VAIDGALFQD EVEARQIMSV PSIYLNGEVF
190 200 210 220 230 240
GQGRMGVEEI LAKIDTGAAA RDAEKLTARD AFDVLVVGGG PAGAAAAIYA ARKGIRTGVA
250 260 270 280 290 300
AERFGGQVLD TMAIENFISV QETEGPKLAR ALEEHVRHYE VDIMNLQRAS KLVPAKNAGE
310 320 330 340 350 360
LHEVRFESGG SLKAKTLILA TGARWREMGV PGEQEYKAKG VCFCPHCDGP LFKGKRVAVI
370 380 390 400 410 420
GGGNSGVEAA IDLAGIVAHV TLLEFDSKLR ADAVLQRKLY SLPNVEVITS ALTSEVKGDG
430 440 450 460 470 480
QKVTGLVYKD RNSEEFKSIE LEGIFVQIGL LPNTEWLKGS VELSPRGEII VDARGETSLP
490 500 510 520
GIFAAGDVTT VPYKQIVIAV GEGAKASLSA FDHLIRTSAP E