Q9I1M0

PR
Gene name
bkdB (PA2249)
Protein name
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
Names
Branched-chain alpha-keto acid dehydrogenase complex component E2, BCKAD-E2, BCKADE2, Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, Dihydrolipoamide branched chain transacylase, Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA2249
EC number
2.3.1.168: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9I1M0

Entry ID Method Resolution Chain Position Source
AF-Q9I1M0-F1 Predicted AlphaFoldDB

No variants for Q9I1M0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9I1M0

No associated diseases with Q9I1M0

4 regional properties for Q9I1M0

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 3 - 78 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 198 - 427 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 28 - 57 IPR003016
domain Peripheral subunit-binding domain 139 - 177 IPR004167

Functions

Description
EC Number 2.3.1.168 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule.
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-dihydrolipoyl)lysine.
lipoic acid binding Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.

1 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGTHVIKMPD IGEGIAEVEL VEWHVQVGDS VNEDQVLAEV MTDKATVEIP SPVAGRILAL
70 80 90 100 110 120
GGQPGQVMAV GGELIRLEVE GAGNLAESPA AATPAAPVAA TPEKPKEAPV AAPKAAAEAP
130 140 150 160 170 180
RALRDSEAPR QRRQPGERPL ASPAVRQRAR DLGIELQFVQ GSGPAGRVLH EDLDAYLTQD
190 200 210 220 230 240
GSVARSGGAA QGYAERHDEQ AVPVIGLRRK IAQKMQDAKR RIPHFSYVEE IDVTDLEALR
250 260 270 280 290 300
AHLNQKWGGQ RGKLTLLPFL VRAMVVALRD FPQLNARYDD EAEVVTRYGA VHVGIATQSD
310 320 330 340 350 360
NGLMVPVLRH AESRDLWGNA SEVARLAEAA RSGKAQRQEL SGSTITLSSL GVLGGIVSTP
370 380 390 400 410 420
VINHPEVAIV GVNRIVERPM VVGGNIVVRK MMNLSSSFDH RVVDGMDAAA FIQAVRGLLE
HPATLFLE