Q9I0Q7
Gene name |
kynA |
Protein name |
Tryptophan 2,3-dioxygenase |
Names |
TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase |
Species |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
KEGG Pathway |
pae:PA2579 |
EC number |
1.13.11.11: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9I0Q7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9I0Q7-F1 | Predicted | AlphaFoldDB |
No variants for Q9I0Q7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9I0Q7 | |||||
No associated diseases with Q9I0Q7
No regional properties for Q9I0Q7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9I0Q7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.11 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| metal ion binding | Binding to a metal ion. |
| tryptophan 2,3-dioxygenase activity | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| tryptophan catabolic process to acetyl-CoA | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. |
| tryptophan catabolic process to kynurenine | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCPCPHSQAQ | GETDGEAEWH | NAALDFTHAM | SYGDYLKLDK | VLDAQFPLSP | DHNEMLFIIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HQTSELWMKL | MLHELRAARE | HVKSGKLGPA | LKMLARVSRI | FDQLVHAWAV | LATMTPTEYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TIRPYLGQSS | GFQSYQYREI | EFILGNKNAT | LLKPHAHRAE | LLAALEQALH | TPSLYDEAIR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LMAAQGLPVS | QERLARDAAA | GTCYEASVEA | AWRQVYQAPE | RYWDLYQLAE | KLIDLEDSFR |
| 250 | 260 | 270 | 280 | ||
| QWRFRHVTTV | ERIIGFKPGT | GGTEGVGYLR | SMLDTILFPE | LWRLRSNL |