Q9I0A4

PR
Gene name
pheT
Protein name
Phenylalanine--tRNA ligase beta subunit
Names
Phenylalanyl-tRNA synthetase beta subunit, PheRS
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA2739
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

325-395 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q9I0A4

Entry ID Method Resolution Chain Position Source
4P71 X-ray 279 A A/B 1-792 PDB
4P72 X-ray 262 A A/B 1-792 PDB
4P73 X-ray 303 A A/B 1-792 PDB
4P74 X-ray 270 A A/B 1-792 PDB
4P75 X-ray 296 A A/B 1-792 PDB
AF-Q9I0A4-F1 Predicted AlphaFoldDB

No variants for Q9I0A4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9I0A4

No associated diseases with Q9I0A4

6 regional properties for Q9I0A4

Type Name Position InterPro Accession
domain tRNA-binding domain 39 - 147 IPR002547
domain Ferrodoxin-fold anticodon-binding domain 698 - 791 IPR005121
domain B3/B4 tRNA-binding domain 211 - 384 IPR005146
domain tRNA synthetase, B5-domain 400 - 476 IPR005147
domain Phenylalanly tRNA synthetase, tRNA-binding-domain 45 - 146 IPR033714
domain Phenylalanyl tRNA synthetase beta chain, core domain 474 - 683 IPR041616

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
phenylalanine-tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFSEKWLRS WANPQVSHDE LVARLSMVGL EVDADLPVAG AFSGVVVGEV LSTEQHPDAD
70 80 90 100 110 120
KLRVCQVSNG SETFQVVCGA PNVRAGLKIP FAMIGAELPD DFKIKKAKLR GVESFGMLCS
130 140 150 160 170 180
AKELQISEEN AGLLELPADA PVGQDVRTYL ELADYTIEVG LTPNRGDCLS LAGLAREVSA
190 200 210 220 230 240
IYDVPLAPVA VDAVAAQHDE TRPVELAAPA ACPRYLGRVI RNVDLSRPTP LWMVERLRRS
250 260 270 280 290 300
DIRSIDPVVD VTNYVMIELG QPMHAFDLAE INGGVRVRMA EDGEKLVLLD GQEITLRADT
310 320 330 340 350 360
LVIADHQRAL AIAGVMGGEH SGVSDSTRDL FLEAAFFDTI ALAGKARSYG LHTDSSHRFE
370 380 390 400 410 420
RGVDSQLARK AMERATRLIL DIVGGEPGPI VEQVSEAHLP KVAPITLRAE RVTQMLGMPL
430 440 450 460 470 480
DAAEIVRLLQ ALELTVVADG EGQWSVGVPS HRFDISLEVD LIEELARLYG YNRLPVRYPQ
490 500 510 520 530 540
ARLAPNNKPE ARAALPLLRR LLVARGYQEA ITFSFIDPAL FELFDPGTQP LTLANPISAD
550 560 570 580 590 600
MAAMRSSLWP GLVKALQHNL NRQQSRVRLF ESGLRFVGQL EGLKQEAMLA GAICGKRLPE
610 620 630 640 650 660
GWANGRDGVD FFDAKADVEA VLASAGALGD FSFVPGEHPA LHPGQTARIE REGRLVGYLG
670 680 690 700 710 720
ALHPELAKKL DLEQPVFLFE LLLAEVVDGH LPKFRELSRF PEVRRDLALL VDQDVPAQDI
730 740 750 760 770 780
LTQIRAAAGE WLTDLRLFDV YHGKGIDPHR KSLAVGLTWQ HPSRTLNDDE VNSTTQNIVT
790
SLEERFNATL RK