Q9HVT2

PR
Gene name
PA4489
Protein name
Alpha-2-macroglobulin homolog
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA4489
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-185 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HVT2

Entry ID Method Resolution Chain Position Source
AF-Q9HVT2-F1 Predicted AlphaFoldDB

No variants for Q9HVT2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HVT2

No associated diseases with Q9HVT2

4 regional properties for Q9HVT2

Type Name Position InterPro Accession
domain Alpha-2-macroglobulin 857 - 947 IPR001599
domain Macroglobulin domain 333 - 428 IPR002890
domain Alpha-2-macroglobulin, bait region domain 646 - 792 IPR011625
conserved_site Alpha-macroglobulin-like, thiol-ester bond-forming region 1045 - 1074 IPR047565

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNLRRFSRS LAVAALVLLP FAAVQAEDTV EPSGYTPMAG ESFFLLADSS FATDEEARVR
70 80 90 100 110 120
LEAPGRDYRR YRMEPYGGVD VRLYRIEQPL EFLKRQKNLH RVLAEGQFKG EGLSNTLAYL
130 140 150 160 170 180
WDNWYRKSRR VMQRAFSYES RQQVTEAVPE LKMGNAMTAP TPYDAQPQYA PIPGLPLVSQ
190 200 210 220 230 240
FRYPLWDAKP IEPPQDVKLA GSSSEFINVV PGNVYIPLGK LKPGLYLVEA LVGKYRATTV
250 260 270 280 290 300
VFVSNSVAVS KVAGDELLVW TARKHEGTPV PDTKVLWTDG LGVMSSGNTD ADGLLRLKHA
310 320 330 340 350 360
SPERSYVIGE DREGGVFVSE NFYYDSEIYD TKIYAFTDRP LYRPGDWVSL KMVGREFKDA
370 380 390 400 410 420
RQSQAAASAP VRLSVIDASG TVLQSLDLRF DAKSGANGRF QLPENAVAGG YELRFDYRGQ
430 440 450 460 470 480
TYSSAFRVAE YIKPHFEVAL DLAKPDFKTA EPVKGEIVLL YPDGKPVANA RLQLSLRAQQ
490 500 510 520 530 540
LSMVDNELQY LGQFPVELSS TELTTDGKGR AAIELPPAEK PSRYMLTIFA SDGAAYRVKT
550 560 570 580 590 600
SKEILIERGA ARYRLSAPQR FSAAGEKVEF SYASEQPTPL KPSSYQWIRL EDRATDSGPV
610 620 630 640 650 660
ADGRFALTFE RPGTYSVELR DDKGQLLGAT GHSVSGEGVK SVPGTVEVVF DKPEYRTGEE
670 680 690 700 710 720
ASALITFPEP VEDALLSLER DKVEATALLS KGADWLRLEK LNPTQYRVWI PVREEFSPNL
730 740 750 760 770 780
TFSVLYTKGG DYSFQNAGIK VGMPQVEIDI ATDKERYEPG ETVTVTLATR FAGKPVSSHL
790 800 810 820 830 840
TVSVVDEMVY ALQAEIAPGI DQFFYHPRRN NVRTSASLAF ISYDVALPGS TSAPGRANRS
850 860 870 880 890 900
ERGVKVLERP RREDVDTAAW QPELVTDAQG KASFSFRMPD SLTRWRITAR AIDDNGQVGQ
910 920 930 940 950 960
KKQFLRSEKP LYLKWSGPTR FRQGDQPDLG LFVFNQGEQP VKAELLSGPP GSQRSQTLEL
970 980 990 1000 1010 1020
AKGVNYIPLA QQPLSDGDWS AELRQDGQVR DRLAVRFNLL ADGWQVEQMQ NLSLAAASNP
1030 1040 1050 1060 1070 1080
LQLPADARDV RLRLADGPAA AYLGNLDDLL EYPYGGVEQT ASQLLPLSIA YPALAGGEPR
1090 1100 1110 1120 1130 1140
IRDRLRLIMQ NSRLRLVQMA GPDAWFAWWG GDVDGDAFLT AYAYYADWYA SRALEIQLPA
1150 1160 1170 1180 1190 1200
EHWQRILEPY AKQATQTPLL QRALILAFAR DMQLPVNTLL GGLLNDLANA GEGQARAEPL
1210 1220 1230 1240 1250 1260
EADDGLVLGD PDSAVGLAAA RVLAVDLARQ LRVAVPAPLA AQAETATQRL REAGLPFTDA
1270 1280 1290 1300 1310 1320
LLASRSAVDG QQASALLQRL APAQSTLERA LALTWLQGAL AQAPQGKLPQ PPKDWQAQRG
1330 1340 1350 1360 1370 1380
ASGETYWQWR GRGIPSWVDL DEAPARPLPV ALSYRSAQAP SGQLPVQISR RLLRLVPGEG
1390 1400 1410 1420 1430 1440
AFEFKVEEVG DKPLSSDELY LDEVTLNVPE DTALRYGMLE LPLPPGADVE RTTWGIKISG
1450 1460 1470 1480 1490 1500
LAGDEATTLE RARNEPGELF YGVPVDSLSG EQRFRHLVRF SQKGSFNLPP ARYLRLYAPE
1510
QQALEAKPAL AKVKVE