Q9HUL4

PR
Gene name
queG
Protein name
Epoxyqueuosine reductase
Names
Queuosine biosynthesis protein QueG
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA4950
EC number
1.17.99.6: With other acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HUL4

Entry ID Method Resolution Chain Position Source
AF-Q9HUL4-F1 Predicted AlphaFoldDB

No variants for Q9HUL4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HUL4

No associated diseases with Q9HUL4

3 regional properties for Q9HUL4

Type Name Position InterPro Accession
domain Epoxyqueuosine reductase QueG, DUF1730 70 - 148 IPR013542
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 193 - 222 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 202 - 213 IPR017900

Functions

Description
EC Number 1.17.99.6 With other acceptors
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
epoxyqueuosine reductase activity Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTPQPLADNL SPPDPARLAQ SIKDWGRELG FQQVGISDVE LGEHEAHLQR WLEAGYHGEM
70 80 90 100 110 120
DYMAAHGSKR SRPAELVPGT LRVISLRMDY LPGDTRMAQV LATPEKAYVS RYALGRDYHK
130 140 150 160 170 180
LIRKRLQQLA ERIQAEVGPF GFRAFVDSAP VLEKAIAEQA GLGWIGKNTL VLNRKAGSYF
190 200 210 220 230 240
FLGELFVDMP LPVDPAMDSE HCGRCSACLD ICPTAAFVGP YRLDARRCIS YLTIEYKGAI
250 260 270 280 290 300
PLELRPLIGN RVFGCDDCQI VCPWNRFARP TGQGDFQPRH SLDNAELAEL FLWSEEEFLG
310 320 330 340 350 360
RTEGSPLRRA GYERWLRNLA VGLGNAPSTI PVLEALKARR GFPSELVREH VEWALRRHGE
T