Q9HT80

PR
Gene name
polA (PA5493)
Protein name
DNA polymerase I
Names
POL I
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA5493
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

259-335 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HT80

Entry ID Method Resolution Chain Position Source
AF-Q9HT80-F1 Predicted AlphaFoldDB

No variants for Q9HT80

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HT80

No associated diseases with Q9HT80

9 regional properties for Q9HT80

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 341 - 408 IPR003141
domain PHP domain 342 - 700 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 422 - 642 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 842 - 1023 IPR011708-1
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 1039 - 1110 IPR011708-2
domain Exonuclease, RNase T/DNA polymerase III 426 - 592 IPR013520
domain DNA polymerase III PolC-like, N-terminal domain II 92 - 205 IPR024754
domain DNA polymerase III PolC-type, N-terminal domain I 5 - 78 IPR028112
domain DNA polymerase III alpha subunit finger domain 1114 - 1270 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

2 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQAPLVLVD GSSYLYRAFH ALPPLTTSTG KPTGAVKGVL NMLLSLRKQY PDSPFAVVFD
70 80 90 100 110 120
AKGPTFRDEL FAEYKANRPS MPDDLRVQVE PLHASVRALG LPLLCVEGVE ADDVIGTLAR
130 140 150 160 170 180
SSAAADRPVV ISTGDKDMAQ LVDGHITLVN TMTGSRLDVD GVKEKFGVGP ELIIDFLALM
190 200 210 220 230 240
GDKVDNIPGV PGVGEKTALG LLTGVGGGLE VLYASLDKVP ELPIRGAKGL PAKLEENREQ
250 260 270 280 290 300
AFLSYQLATI KTDVELDVEI DKLYPGEPQR EALIALYREL EFKNWLDDLL REAKEAGENG
310 320 330 340 350 360
EAETPIQAEV DYDVVLDQAG FDAWLKKLEE AELIAFDTET TSIDAQQAQV VGVSFAVKEG
370 380 390 400 410 420
EAAYVPLAHS YMGVPEQLDR DAVLRALKPL LEDPKKLKVG QHAKYDINVL ANASTPIALR
430 440 450 460 470 480
GVAYDTMLES YVLDSTATRH DMDSLALKYL GHSTIRFEDI AGKGAKQLTF DQIAIEQAGP
490 500 510 520 530 540
YAAEDADVTL RLHQALWQKL EAIPSLARVL TDIEMPLVPV LARIERNGAL VDANLLGIQS
550 560 570 580 590 600
RELGEKMVAL ERQAYDLAGQ EFNLGSPKQL GAILYDKLGL PVLSKTATGQ PSTAEAVLAE
610 620 630 640 650 660
LAEQDFELPK VIMQYRSMSK LKSTYTDRLP EQINPRTGRI HTSYHQAVAA TGRLSSSDPN
670 680 690 700 710 720
LQNIPIRTAE GRRIRQAFVA PQGYKLLAAD YSQIELRIMA HLAKDDGLLD AFRHDLDVHR
730 740 750 760 770 780
ATAAEVFGVP LEDVSGDQRR SAKAINFGLI YGMSAFGLAK QIGVERKEAQ AYIDRYFARY
790 800 810 820 830 840
PGVLAYMERT RAQAAEQGFV ETLFGRRLYL PEIHSKNGAM RKAAERTAIN APMQGTAADI
850 860 870 880 890 900
MKRAMVAVDN WLQESGLDAR VILQVHDELV LEVREDLVEQ VCEGIRPLMS GAATLDVPLV
910
VEAGVGSNWD EAH