Q9HM14

PR
Gene name
Ta0057
Protein name
ATP-dependent DNA helicase Ta0057
Names
Species
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
KEGG Pathway
tac:Ta0057
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q9HM14

Entry ID Method Resolution Chain Position Source
2VSF X-ray 290 A A 1-602 PDB
4A15 X-ray 220 A A 2-602 PDB
5H8W X-ray 220 A A 1-597 PDB
AF-Q9HM14-F1 Predicted AlphaFoldDB

No variants for Q9HM14

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HM14

No associated diseases with Q9HM14

1 regional properties for Q9HM14

Type Name Position InterPro Accession
binding_site Pyridoxal-phosphate binding site 311 - 332 IPR021115

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKSYGVALE SPTGSGKTIM ALKSALQYSS ERKLKVLYLV RTNSQEEQVI KELRSLSSTM
70 80 90 100 110 120
KIRAIPMQGR VNMCILYRMV DDLHEINAES LAKFCNMKKR EVMAGNEAAC PYFNFKIRSD
130 140 150 160 170 180
ETKRFLFDEL PTAEEFYDYG ERNNVCPYES MKAALPDADI VIAPYAYFLN RSVAEKFLSH
190 200 210 220 230 240
WGVSRNQIVI ILDEAHNLPD IGRSIGSFRI SVESLNRADR EAQAYGDPEL SQKIHVSDLI
250 260 270 280 290 300
EMIRSALQSM VSERCGKGDV RIRFQEFMEY MRIMNKRSER EIRSLLNYLY LFGEYVENEK
310 320 330 340 350 360
EKVGKVPFSY CSSVASRIIA FSDQDEEKYA AILSPEDGGY MQAACLDPSG ILEVLKESKT
370 380 390 400 410 420
IHMSGTLDPF DFYSDITGFE IPFKKIGEIF PPENRYIAYY DGVSSKYDTL DEKELDRMAT
430 440 450 460 470 480
VIEDIILKVK KNTIVYFPSY SLMDRVENRV SFEHMKEYRG IDQKELYSML KKFRRDHGTI
490 500 510 520 530 540
FAVSGGRLSE GINFPGNELE MIILAGLPFP RPDAINRSLF DYYERKYGKG WEYSVVYPTA
550 560 570 580 590 600
IKIRQEIGRL IRSAEDTGAC VILDKRAGQF RKFIPDMKKT SDPASDIYNF FISAQAREKY
GA