Q9HM08

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
KEGG Pathway
tac:Ta0063
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

316-405 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HM08

Entry ID Method Resolution Chain Position Source
AF-Q9HM08-F1 Predicted AlphaFoldDB

No variants for Q9HM08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HM08

No associated diseases with Q9HM08

8 regional properties for Q9HM08

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 131 - 223 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 266 - 515 IPR003602
domain TOPRIM domain 4 - 140 IPR006171
domain DNA topoisomerase, type IA, central 104 - 117 IPR013497-1
domain DNA topoisomerase, type IA, central 156 - 563 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 671 - 708 IPR013498
active_site DNA topoisomerase, type IA, active site 302 - 316 IPR023406
domain DNA topoisomerase 3-like, TOPRIM domain 5 - 152 IPR034144

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDGFRIIIAE KADAGRRIAY FLSGGQVKSH RAKGTSYLEF EYNGSKTYLI PLSGHIVEAD
70 80 90 100 110 120
FESGYSDWNK IDLSDLIDAR IVKNIKNKVA YQTLQAFRGK VEEIVIATDY DREGELIGVE
130 140 150 160 170 180
ALDIIKEGKE EIRRAKFSAL TKNEILDSFK NLIGVNYSLA DAADARESID LIWGSVLTRF
190 200 210 220 230 240
FSVTTGRLGK SFLSAGRVQT PTLAIVVDRE REIQSFRPER YWTISITFDK DGQFKARYPE
250 260 270 280 290 300
NIKDQDTAEK IYEAIKGKNG RVSSYTSKED HIRRPAPFST TEFLREASRI GIMPTKAMSI
310 320 330 340 350 360
AENLYMRGLI SYPRTDNTVY PRSINLKSVL KKLENTAYSK YVKEIETFDR ILPSRGRIET
370 380 390 400 410 420
TDHPPIYPVD SPKEQLKGDY GRVYDLILRH FLSTLYRDGK KTVAEAEIYV NGYTFKAAGQ
430 440 450 460 470 480
HTTDRGWTEI YGYDPKDVYL PELTEGEDLK AIDWNIQREE TKPPPRYDMS SLLKKMEELN
490 500 510 520 530 540
LGTKSTRHDI IGKLIERGFI EGNPVKPTPL GMAFIDAVRS VNSHIADPEM TAKLEEDMDR
550 560 570 580 590 600
IEKNEMSKND VVEESKKMLH EVLSHFLTKT ADVKDIITKG INAGQEIGDC PFHEGKKIMV
610 620 630 640 650 660
IRDRFTYTVR CEDPSCKINF RIKRNGSITL SDQKCPVCGL PMIKIIRKGQ SPEIKCIDPD
670 680 690 700 710 720
CSYNRENEDY GECPADHGRL VLRQSKYGKR FLGCSNYPKC TVTYPLPQMG RITKTGEVCP
730 740 750 760
YCGAPILALS RNGRKWKFCP NMQCEYNKKR KPEAAVEKSV RKKGRNASKS