Q9HLV2

PR
Gene name
pckG
Protein name
Phosphoenolpyruvate carboxykinase [GTP]
Names
PEP carboxykinase, PEPCK
Species
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
KEGG Pathway
tac:Ta0123
EC number
4.1.1.32: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HLV2

Entry ID Method Resolution Chain Position Source
AF-Q9HLV2-F1 Predicted AlphaFoldDB

No variants for Q9HLV2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HLV2

No associated diseases with Q9HLV2

2 regional properties for Q9HLV2

Type Name Position InterPro Accession
domain Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain 232 - 585 IPR035077
domain Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal 15 - 228 IPR035078

Functions

Description
EC Number 4.1.1.32 Carboxy-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
manganese ion binding Binding to a manganese ion (Mn).
phosphoenolpyruvate carboxykinase (GTP) activity Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

1 GO annotations of biological process

Name Definition
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLAIDESELN QHAMKWIEGI KKFTEAEDVV VCDGTPEEFK QISNELIKSG EFIKLNENRY
70 80 90 100 110 120
PNSFLYRSDR TDVARSEERT FIAAPDASMA GSLNNHMTLQ QVSEVWNKFF RGAYRGKTMF
130 140 150 160 170 180
VIPYALGPLN SRFTDYGIEI TDSRYVVLNL HYITRMGKQV IGSMPEKFVK GVHATGTLDP
190 200 210 220 230 240
GNKFIIHIPW DKPEGVDADI LSVNTNYGGN ALLSKKCHAL RIASVRARKE GWLAEHMLLL
250 260 270 280 290 300
EVEDPHGRKV YITGAFPSAS GKTNLAMINP PKQYAEAGWK TRLLSDDIAW MKMKDGMLYA
310 320 330 340 350 360
TNPENGFFAV VPGTNYRTNK NAMITLSRNT IFTNTGMTKT GEPWWEGLDP LQEELYDWKG
370 380 390 400 410 420
VLRKPDGEPI AHPNSRFTSP LSNYPFLSDR SEDPEGVPVS AILFGGRRAS LVPLVYEAFN
430 440 450 460 470 480
WNHGVFMGAT MGVEKTAASE GKVGELRRDP MAMRPFCGYN ISDYFRHWIE MGRKLSRRPK
490 500 510 520 530 540
IFYVNWFRRR QDGSFIWPGF SENFRVIEWI LYRLDHNDNA IETPIGYIPE NINTDGLNLT
550 560 570 580
KQDMEELFRI DRDGWREEMK SIGDYFSQIG NIPEDLLIEF EMEKRRIS