Q9HK01

PR
Gene name
Ta0809
Protein name
D-glyceraldehyde dehydrogenase (NADP(+))
Names
GADH, Glyceraldehyde DH
Species
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
KEGG Pathway
tac:Ta0809
EC number
1.2.1.89: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

288-361 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q9HK01

Entry ID Method Resolution Chain Position Source
5IZD X-ray 205 A A/B/C/D/E/F/G/H 1-493 PDB
5J77 X-ray 210 A A/B/C/D 1-493 PDB
5M4X X-ray 356 A A/B/C/D 1-493 PDB
AF-Q9HK01-F1 Predicted AlphaFoldDB

No variants for Q9HK01

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HK01

No associated diseases with Q9HK01

3 regional properties for Q9HK01

Type Name Position InterPro Accession
domain Aldehyde dehydrogenase domain 11 - 473 IPR015590
conserved_site Aldehyde dehydrogenase, cysteine active site 274 - 285 IPR016160
conserved_site Aldehyde dehydrogenase, glutamic acid active site 246 - 253 IPR029510

Functions

Description
EC Number 1.2.1.89 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
glyceraldehyde dehydrogenase (NADP) activity Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+.
protein homodimerization activity Binding to an identical protein to form a homodimer.

3 GO annotations of biological process

Name Definition
Entner-Doudoroff pathway through 6-phosphogluconate A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
protein homotetramerization The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDTKLYIDGQ WVNSSSGKTV DKYSPVTGQV IGRFEAATRD DVDRAIDAAE DAFWAWNDLG
70 80 90 100 110 120
SVERSKIIYR AKELIEKNRA ELENIIMEEN GKPVKEAKEE VDGVIDQIQY YAEWARKLNG
130 140 150 160 170 180
EVVEGTSSHR KIFQYKVPYG IVVALTPWNF PAGMVARKLA PALLTGNTVV LKPSSDTPGS
190 200 210 220 230 240
AEWIVRKFVE AGVPKGVLNF ITGRGSEIGD YIVEHKKVNL ITMTGSTATG QRIMQKASAN
250 260 270 280 290 300
MAKLILELGG KAPFMVWKDA DMDNALKTLL WAKYWNAGQS CIAAERLYVH EDIYDTFMSR
310 320 330 340 350 360
FVELSRKLAL GDPKNADMGP LINKGALQAT SEIVEEAKES GAKILFGGSQ PSLSGPYRNG
370 380 390 400 410 420
YFFLPTIIGN ADQKSKIFQE EIFAPVIGAR KISSVEEMYD LANDSKYGLA SYLFTKDPNI
430 440 450 460 470 480
IFEASERIRF GELYVNMPGP EASQGYHTGF RMTGQAGEGS KYGISEYLKL KNIYVDYSGK
490
PLHINTVRDD LFQ