Q9HH06

PR
Gene name
pol
Protein name
DNA polymerase
Names
Species
Pyrococcus glycovorans
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

342-412 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HH06

Entry ID Method Resolution Chain Position Source
AF-Q9HH06-F1 Predicted AlphaFoldDB

3 variants for Q9HH06

Variant ID(s) Position Change Description Diseaes Association Provenance
430 R>M strain: AL585 [UniProt] No
467 K>R strain: AL585 [UniProt] No
754 G>E strain: AL585 [UniProt] No

No associated diseases with Q9HH06

4 regional properties for Q9HH06

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 22 - 129 IPR006133-1
domain DNA-directed DNA polymerase, family B, exonuclease domain 130 - 278 IPR006133-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 352 - 748 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 539 - 547 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILDADYITE DGKPIIRIFK KENGEFKVEY DRNFRPYIYA LLKDDSQIDE VKKITAERHG
70 80 90 100 110 120
KIVRIVDVEK VKKKFLGRPI EVWKLYFEHP QDVPAIRDKI REHPAVVDIF EYDIPFAKRY
130 140 150 160 170 180
LIDKGLIPME GDEELKLLAF DIETLYHEGE EFAKGPIIMI SYADEEGAKV ITWKKVDLPY
190 200 210 220 230 240
VEVVSSEREM IKRFLKVIRE KDPDVIITYN GDSFDLPYLV KRAEKLGIKL PLGRDGSEPK
250 260 270 280 290 300
MQRLGDMTAV EIKGRIHFDL YHVIRRTINL PTYTLEAVYE AIFGKPKEKV YAHEIAEAWE
310 320 330 340 350 360
TGKGLERVAK YSMEDAKVTY ELGREFFPME AQLSRLVGQP LWDVSRSSTG NLVEWYLLRK
370 380 390 400 410 420
AYERNELAPN KPDEREYERR LRESYAGGYV KEPEKGLWEG LVSLDFRSLY PSIIITHNVS
430 440 450 460 470 480
PDTLNREGCR EYDVAPEVKH KFCKDFPGFI PSLLKRLLDE RQEIKRKMKA SKDPIEKKML
490 500 510 520 530 540
DYRQRAIKIL ANSYYGYYGY AKARWYCKEC AESVTAWGRE YIEFVRKELE EKFGFKVLYI
550 560 570 580 590 600
DTDGLYATIP GAKPEEIKRK ALEFVEYINA KLPGLLELEY EGFYVRGFFV TKKKYALIDE
610 620 630 640 650 660
EGKIITRGLE IVRRDWSEIA KETQAKVLEA ILKHGNVEEA VKIVKEVTEK LSKYEIPPEK
670 680 690 700 710 720
LVIYEQITRP LHEYKAIGPH VAVAKRLAAR GVKVRPGMVI GYIVLRGDGP ISKRAILAEE
730 740 750 760 770
FDPRKHKYDA EYYIENQVLP AVLRILEAFG YRKGDLRWQK TKQTGLTAWL NVKKK