Q9HH05

PR
Gene name
pol
Protein name
DNA polymerase
Names
Species
Thermococcus hydrothermalis
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1533-1611 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HH05

Entry ID Method Resolution Chain Position Source
AF-Q9HH05-F1 Predicted AlphaFoldDB

No variants for Q9HH05

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HH05

No associated diseases with Q9HH05

24 regional properties for Q9HH05

Type Name Position InterPro Accession
domain Hint domain C-terminal 953 - 1001 IPR003586-1
domain Hint domain C-terminal 1393 - 1439 IPR003586-2
domain Hint domain N-terminal 457 - 582 IPR003587-1
domain Hint domain N-terminal 1043 - 1159 IPR003587-2
domain Intein DOD homing endonuclease 739 - 872 IPR004042-1
domain Intein DOD homing endonuclease 1191 - 1330 IPR004042-2
domain Homing endonuclease, LAGLIDADG 831 - 888 IPR004860-1
domain Homing endonuclease, LAGLIDADG 1283 - 1368 IPR004860-2
domain DNA-directed DNA polymerase, family B, exonuclease domain 1 - 96 IPR006133-1
domain DNA-directed DNA polymerase, family B, exonuclease domain 97 - 245 IPR006133-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 319 - 460 IPR006134-1
domain DNA-directed DNA polymerase, family B, multifunctional domain 995 - 1035 IPR006134-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 1434 - 1640 IPR006134-3
ptm Intein N-terminal splicing region 462 - 558 IPR006141-1
ptm Intein N-terminal splicing region 1045 - 1136 IPR006141-2
domain Intein 545 - 558 IPR006142-1
domain Intein 736 - 748 IPR006142-2
domain Intein 1287 - 1299 IPR006142-3
domain Intein 1317 - 1332 IPR006142-4
domain Intein 1410 - 1427 IPR006142-5
domain Intein 1428 - 1437 IPR006142-6
domain Intein C-terminal splicing region 972 - 996 IPR030934-1
domain Intein C-terminal splicing region 1412 - 1434 IPR030934-2
domain DNA polymerase II intein domain IV 582 - 729 IPR041005

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

3 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
FEPYIYALLK DDSAIEEVKK ITAGRHGRVV KVKRAEKVKK KFLGRPIEVW KLYFTHPQDV
70 80 90 100 110 120
PAIRDEIRRH SAVVDIYEYD IPFAKRYLID KGLIPMEGDE ELKMMSFDIE TLYHEGEEFG
130 140 150 160 170 180
TGPILMISYA DEGEARVITW KKIDLPYVEV VSTEKEMIKR FLKVVKEKDP DVLITYNGDN
190 200 210 220 230 240
FDFAYLKKRC EKIGIKFTLR RDGSEPKIQR MGDRFAVEVK GRIHFDLYPV IRRTINLPTY
250 260 270 280 290 300
TLEAVYEAVF GTPKEKVYPE EITTAWETGE GLERVARYSM EDAKVTYELG REFFPMEAQL
310 320 330 340 350 360
SRLIGQSLWD VSRSSTGNLV EWFLLRKAYE RNEIAPNKPD ERELARRRGG YAGGYVKEPE
370 380 390 400 410 420
RGLWDNIVYL DFMSLYPSII ITHNVSPDTF NREGCKEYDT APQVGHKFCK DVQGFIPSLL
430 440 450 460 470 480
GALLDERQKI KKRMKASIDP LEKKLLDYRQ KAIKILANSL LPEEWIPLVE NGKVRLHRIG
490 500 510 520 530 540
EFVDKLMETD SELVKRNGDT EVLEVRGIRA LSFDRKSKKA RVMPVKAVIR HRYSGDVYEI
550 560 570 580 590 600
VLGSGRRITV TEGHSLFAYG DGELREVTGG EIKAGDLLAV PRRVNLPEKK ERLNLVELLR
610 620 630 640 650 660
RLPEEETGDI ILTIPVKGRK NFFKGMLRTL RWISGEEKRP RTARRYLEHL EGLGYVRLKK
670 680 690 700 710 720
IGYEVTDREG LERYRKLYER LVEAVRYNGN KREYLVEFNA VRDVIALMPE EELRDWLVGT
730 740 750 760 770 780
RNGFRMRPFV EIEEDFAKLL GYYVSEGNAR KWRNQKNGWS YTVKLYNENQ RVLDDMESLA
790 800 810 820 830 840
ERFFGRVKRG KNYIEIPRKM AYIIFENLCG TLAENKRVPE AIFTSPESVR WAFIEGYFIG
850 860 870 880 890 900
DGDVHPSKRV RLSTKSELLV NGLVLLLNSL GVSAIKIRHD SGVYRVYVNE ELPFTDYRKK
910 920 930 940 950 960
KNAYYSHVIP KEILEETFGK VFQRSVSYEK FRELVKSEKL DGEKAKRIEW LLNGDVVLDK
970 980 990 1000 1010 1020
VLEVKKRPYE GYVYDLSVEE DENFLAGFGL LYAHNSYYGY YGYARARWYC KECAESVTAW
1030 1040 1050 1060 1070 1080
GRDYIETTIH EIEERFGFKV LYADSVTGET EIIIKRNGKV EFVAIEELFQ RVDYRIGEKE
1090 1100 1110 1120 1130 1140
YCVLEGVEAL TLDNRGRLVW KSVPYVMRHR TNKRIYRVWF TNSWYLDVTE DHSLIGYMNT
1150 1160 1170 1180 1190 1200
SKVKPGKPLK ERLVEVKPGE LGESVKSLIT PNRAIAHGIR VNPIAVKLWE LIGLLVGDGN
1210 1220 1230 1240 1250 1260
WGGQSNWAKY NVGLSLGLDK EEIEEKILKP LKNTGIISNY YDKSKKGDVS ILSKWLARFM
1270 1280 1290 1300 1310 1320
VRYFKDESGS KRIPEFMFNL PREYIEAFLR GLFSADGTVS LRKGVPEVRL TSVNPELSSS
1330 1340 1350 1360 1370 1380
VRKLLWLVGV SNSMFVETNP NRYLGKESGT HSVHVRIKDK HRFAERIGFL LDRKATKLSE
1390 1400 1410 1420 1430 1440
NLGGHTSKKR AYKYDFDLVY PKKVEEIAYD GYVYDIEVEG THRFFANGIL VHNTDGFFAT
1450 1460 1470 1480 1490 1500
IPGADAETVK KKAKEFLKYI NAKLPGLLEL EYEGFYVRGF FVTKKKYAVI DEEGKITTRG
1510 1520 1530 1540 1550 1560
LEIVRRDWSE IAKETQARVL EAILRHGDVE EAVRIVKDVT EKLSKYEVPP EKLVIHEQIT
1570 1580 1590 1600 1610 1620
RELKDYKATG PHVAIAKRLA ARGIKIRPGT VISYIVLKGS GRIGDRAIPF DEFDPTKHRY
1630 1640 1650 1660
DAEYYIENQV LPAVERILKA FGYKKEELRY QKTRQVGLGA WLKLKGKK