Q9HGN6

PR
Gene name
dus1
Protein name
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]
Names
mRNA-dihydrouridine synthase dus1, tRNA-dihydrouridine synthase 1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC36B7.04
EC number
1.3.1.88: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

346-399 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HGN6

Entry ID Method Resolution Chain Position Source
AF-Q9HGN6-F1 Predicted AlphaFoldDB

No variants for Q9HGN6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HGN6

No associated diseases with Q9HGN6

2 regional properties for Q9HGN6

Type Name Position InterPro Accession
conserved_site tRNA-dihydrouridine synthase, conserved site 103 - 121 IPR018517
domain DUS-like, FMN-binding domain 19 - 247 IPR035587

Functions

Description
EC Number 1.3.1.88 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Nucleus
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
tRNA dihydrouridine synthase activity Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.
tRNA-dihydrouridine16 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) <=> H+ + a uracil16 in tRNA + NAD(P)H.
tRNA-dihydrouridine17 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) <=> H+ + a uracil17 in tRNA + NAD(P)H.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
tRNA dihydrouridine synthesis The process whereby a uridine in a transfer RNA is converted to dihydrouridine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASKKLHGRD FYNKIGRPKR ILAPMVDQSE LPWRILARRS GADLCYSPMF HSRLFGESED
70 80 90 100 110 120
YRNKVFSTRT IPEERPLIIQ FCGNDPEIML KAAKIAAPYC DAVDVNLGCP QGIAKKGKYG
130 140 150 160 170 180
SFLQENWNLI ESIITKLHTE LSIPVTAKIR IFPDPQKTLD YAKMILKAGA SILAVHGRLR
190 200 210 220 230 240
EQKGHFTGIA DWEQIQMLRK NLPSETVLFA NGNILHAQDI DRCIKYTGVD GVLSAEGSLY
250 260 270 280 290 300
NPRIFLPPSS PLMTLYPRID DMCEEYLNII REFKLESDYS SLSAIKGHLF KLMRPLLSIH
310 320 330 340 350 360
TDIRSKLAQG CTPRDFETFP PVVAMLRKRL LECEEKGEIN EDKDVKESVK DSMGYPVIPW
370 380 390
WRVQPYIRPL EVPLVTKRKP VEVTADEGPV KKKVNASVA