Q9HGM2

PR
Gene name
get1 (SPBC543.10)
Protein name
Protein get1
Names
Guided entry of tail-anchored proteins 1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC543.10
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HGM2

Entry ID Method Resolution Chain Position Source
AF-Q9HGM2-F1 Predicted AlphaFoldDB

No variants for Q9HGM2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HGM2

No associated diseases with Q9HGM2

No regional properties for Q9HGM2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9HGM2

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
GET complex An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
membrane insertase activity Binds transmembrane domain-containing proteins and mediates their integration into a membrane.

1 GO annotations of biological process

Name Definition
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMDLIISTIL LSLFIHFFDK FAKKRTIDGA YRIYVSVSNN KDLKKNKEIL EQLLTVKKEL
70 80 90 100 110 120
NATSSQDQFA KWARLNRKYE QLSQEWEKQS ANVKIFQDTF KRVLSLFLWI LTRGFRFYIQ
130 140 150 160 170
FKESKTPVFF LPAFLLPSWA LWVLSLPRSI YGSVSLTVWN FAVQKTISGI F