Q9HFW3
PR
Gene name |
TRF5 (AEL207W) |
Protein name |
Poly(A) RNA polymerase protein 1 |
Names |
Topoisomerase 1-related protein TRF5 |
Species |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
KEGG Pathway |
ago:AGOS_AEL207W |
EC number |
2.7.7.19: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9HFW3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9HFW3-F1 | Predicted | AlphaFoldDB |
No variants for Q9HFW3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9HFW3 | |||||
No associated diseases with Q9HFW3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.19 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| TRAMP complex | A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| polynucleotide adenylyltransferase activity | Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| histone mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). |
| nuclear polyadenylation-dependent CUT catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. |
| nuclear polyadenylation-dependent mRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. |
| nuclear polyadenylation-dependent rRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. |
| nuclear polyadenylation-dependent snoRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. |
| nuclear polyadenylation-dependent snRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. |
| nuclear polyadenylation-dependent tRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. |
| polyadenylation-dependent snoRNA 3'-end processing | Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. |
| RNA 3'-end processing | Any process involved in forming the mature 3' end of an RNA molecule. |
| sno(s)RNA polyadenylation | The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA class molecule (referred to as an sRNA in Archaea). In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation. |
| U4 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U4 snRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMTASVAGNR | SGRSGNIARE | RSNRSRGAQK | SDKERNLSKG | SSRPKSNSSR | VKKMRKSSLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KVQKNFAVFN | DSAEHENKYE | TLAVAEADEK | EVILLDEEED | TAMTTETKGV | HAEETANVTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEGVNAAANA | LDDNQDFIGF | SDSEEEVASG | EENGDADYAV | EDAEDESSEP | LPTNADYPWI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QNHDHSRQRE | IADWLTLEIK | DFVSYISPNK | TEIQLRNDAL | KRIRDAVQDF | WPDANLHCFG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SYATDLYLPG | SDIDCVVNSK | SGDKDNKNAL | YSLASYLKRN | GLATQVSVIA | KARVPIIKFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EPASQIHIDL | SFERTNGVEA | AKIIRGWLHD | TPGLRELVLI | VKQFLHARRL | NDVHIGGLGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSIICLAYSF | LKLHPRIICR | DIEPLQNLGV | LLIDFFELYG | KNFGYDDVGI | AVSEGDASYI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NKKEYPELTR | NLRGTFNLVI | QDPGDPANNI | SRGSFNIRDI | KKAFAGAFEL | LTNRCFELDA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ATFKHRVGKS | ILGNVIKYRG | AKRDFKDERA | LIVNKAIQEN | EEFHQRRGRI | VHRDTAEFIN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ISDDDDYELQ | PPPKRARVPA | PAPAPADNVV | VLDDPADDYV | PAQPVDKLMG | LDDTDDYLPA |
| 610 | 620 | ||||
| PASPTDTPKL | DKAAKRNYWL | SKGQTM |