Q9HFR0
Gene name |
csn2 (SPAPB17E12.04c) |
Protein name |
COP9 signalosome complex subunit 2 |
Names |
CSN complex subunit 2, SGN2 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAPB17E12.04c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9HFR0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9HFR0-F1 | Predicted | AlphaFoldDB |
2 variants for Q9HFR0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1274398_T_C | 25 | I>V | No | Jeffares_SNPs | |
| I_1274254_C_A | 59 | K>N | No | Jeffares_SNPs |
No associated diseases with Q9HFR0
1 regional properties for Q9HFR0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Proteasome component (PCI) domain | 249 - 431 | IPR000717 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol hexakisphosphate binding | Binding to inositol hexakisphosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNDFMLEDD | ENYDFEFEDD | DDDMIEPYVD | VENCYYNSKS | LKEENPESAL | TSFYSIVEKC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EGEQNEWAFK | ALKQITKINF | QLKKYDDMLQ | SYQRLLGYTN | WLSITKNYSE | KSIYNIVEYA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSCENTEFLE | KFYDVTTKAL | QNLNNERLML | KVLMHVARFL | LTQKNYHKFK | YLLRQMHELL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDENNSVADQ | NRGTHLLELY | SLEIQMYSDI | EDNKRLKELY | QSSLRVKTAI | PHPRIMGIIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ECGGKMHMQE | NQWSEAQTNF | FESFKSYDEA | GSSDRIRVLK | YLVLANMLSE | SEINPFDSPE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TQPYKDNPHI | IAMTKLVEAY | QIRDITAVER | ILQTYQHDIL | DDDFIRQYVD | KILYSIRSQV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LIELVKPYTS | VKLSLLAKKL | GVSISIIEQA | LVGLIIDERV | NGKIDMVNEV | FTISQPKNTI |
| 430 | |||||
| HNQLVEDVQK | LWNTATK |