Q9HF78

PR
Gene name
GCS1
Protein name
Glutamate--cysteine ligase
Names
Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase
Species
Candida albicans (Yeast)
KEGG Pathway
EC number
6.3.2.2: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

546-656 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9HF78

Entry ID Method Resolution Chain Position Source
AF-Q9HF78-F1 Predicted AlphaFoldDB

No variants for Q9HF78

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9HF78

No associated diseases with Q9HF78

No regional properties for Q9HF78

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9HF78

Functions

Description
EC Number 6.3.2.2 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.

3 GO annotations of biological process

Name Definition
glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGLLSIGTPL SWDESKKYNN HVRTNGITQL INIFKQHGYR ENDVFLWGDE VEYMLVDFDE
70 80 90 100 110 120
TKKTARLSID KDYIINDLND PDKLLPIAEK QDVSYHPEYG RFMVEATPAK PYNGNLLSDY
130 140 150 160 170 180
LYIEKNMIIR RQLCEDNLPS HIKLLTLTTF PRMGCNIFTS PPSKPDGIAS QSLFLPDEII
190 200 210 220 230 240
NRHARFPTLT ANIRKRKGHK VAINLPIYPD KSTKLLDDTI PQNRELFDSD KEPWIGASKP
250 260 270 280 290 300
GFIYMDSMGF GMGSSCLQIT MQTKNISQAR YLYDSLAPIA PIMLSLSAAA PIFKGFLVDQ
310 320 330 340 350 360
DVRWNVVSGA VDDRTFIEKG QEPYSGYHLF GGLDIDAQDK LRINNHQINQ QGDLLDLYTK
370 380 390 400 410 420
DGKPIQRVPQ SRYDSIDNYL NDNYYDTKYF QDEYNDLNAP INEQVYQRLI DEGKLDKYMA
430 440 450 460 470 480
NHFAHLFIRD PLVIFSERIN QDNNLENDHF ENIQSTNWQT LRFKPPALYT KDTDLTTKPG
490 500 510 520 530 540
WRVEFRPMEI QLTDFENAAY SSFITLLSKA ILKFQPNFYI PLSKVEINMK LAHKVDSTLK
550 560 570 580 590 600
DKFWFRSFEL WNIDPQEFDD YGFEWFDQFI NGNQQQNGHV NNNNNNDKKT KNDPIIVNGS
610 620 630 640 650 660
TTTTNGTNSG SGITETNGTM LPKGCEGKTV EEINDVDDNG IDQRYTICQL INGSGEFPGF
670 680
IKLVIKLIAT DLVPQALNNS TISKEQLIEN