Q9HEH1
Gene name |
2E4.130 (NCU04242) |
Protein name |
Regulator of nonsense transcripts 1 homolog |
Names |
|
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU04242 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9HEH1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9HEH1-F1 | Predicted | AlphaFoldDB |
No variants for Q9HEH1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9HEH1 | |||||
No associated diseases with Q9HEH1
7 regional properties for Q9HEH1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase superfamily 1/2, ATP-binding domain | 452 - 686 | IPR014001 |
| domain | RNA helicase UPF1, Cys/His rich zinc-binding domain | 95 - 252 | IPR018999 |
| domain | RNA helicase UPF1, 1B domain | 305 - 399 | IPR040812 |
| domain | DNA2/NAM7 helicase, helicase domain | 456 - 558 | IPR041677-1 |
| domain | DNA2/NAM7 helicase, helicase domain | 566 - 658 | IPR041677-2 |
| domain | DNA2/NAM7 helicase-like, C-terminal | 665 - 861 | IPR041679 |
| domain | Upf1-like, C-terminal helicase domain | 689 - 878 | IPR047187 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| double-stranded DNA helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA duplex unwinding | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANMEVSFTH | LGNHLVSDSA | AAIKAGGSDE | LSNIDPDENL | LYGVYGGRGP | RGNGRRRHDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDNETEVLDD | DDDESLASVP | VDGMKSLKLD | APVEEKELPP | HACAYCGIHS | PSSVVKCLTC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NKWFCSAKGS | AFSSHIVNHL | VRARHKEVQL | HPESSLGDTV | LECYNCGTKN | VFILGFIPAK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDTVVVLLCR | QPCGASTSTK | DMSWDISRWQ | PLIEDRAFLN | WLVTPPTDAE | QLRARHLTPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MIAKLEEMWK | EAPNATVADL | EKTAGVDDDP | HPVLLKYDDP | YHYQNIFGPL | VKMESDYDKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKEAQSEDGL | QVRWHLGLNS | KHVASFILPK | IESGDVKLAV | GDEMRLKYKG | ELRPPWEGVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YVIKIPNNQS | DEVEVELRKS | ANDKSVPTEC | THNFSADYVW | KATSYDRMQL | AMKTFAVDEM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SVSGYIFHKL | LGHEVQVAPT | KITMPKKFHV | PGLPELNASQ | IAAIKQVLSN | PLSLIQGPPG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TGKTVTSATI | IYHLAKMSNS | QVLVCAPSNV | AVDQLCERIH | RTGLKVVRLT | AKSREDVESS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSFLALHEQV | RMNTTNKELD | GLVKLKTETG | ELSSQDEKRF | KQLTRQAERE | ILQNADVVCC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TCVGAGDPRL | SKMKFRNVLI | DESTQSAEPE | CMIPLVLGCK | QVVLVGDHKQ | LGPVIMNKKA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AKAGLNQSLF | ERLVKLQFTP | IRLKVQYRMH | PCLSEFPSNM | FYEGSLQNGV | TAAERLRKDV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DFPWPVPETP | MMFWSNLGNE | EISASGTSYL | NRTEAANVEK | IVTRFFKAGV | KPADIGVITP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YEGQRSYIVN | TMQNTGTFKK | ESYREVEVAS | VDAFQGREKD | FIVLSCVRSN | ENQGIGFLSD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PRRLNVALTR | AKYGLVIIGN | PKVLCKHELW | HHLLVHFKDK | KCLVEGPLTN | LQPSLLQFGR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PRQAYRPQRS | HTQHVASGPS | NGRFAAPLTA | GSVRDYETGS | MVSYIPDDVS | SIHSSALGGA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ALSSGYPAMF | SNFHPEAWAG | LPCAGPNGRP | GAKGRGRATE | SIAGESVANS | EFTDATSSVI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GGKGIGQGGA | SLGAGLSEAI | GSARPTSYSQ | SDRLKQYVES | NGRMGVGNGY | RRYDDDEKSV |
| 1090 | |||||
| STAFASQIGT | GFD |