AiPD: Autoinhibited Protein Database

Q9H9H5

Gene name	MAP6D1
Protein name	MAP6 domain-containing protein 1
Names	21 kDa STOP-like protein, SL21
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79929
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-140 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

6-140 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9H9H5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H9H5-F1	Predicted				AlphaFoldDB

218 variants for Q9H9H5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1412451282 CA355357180	2	A>P		No	ClinGen TOPMed
rs1363765614 CA355357176	2	A>V		No	ClinGen TOPMed gnomAD
CA2723304 rs771395990	3	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1358048859 CA355357169	3	W>*		No	ClinGen TOPMed
rs1448178502 CA355357162	4	P>L		No	ClinGen TOPMed
rs1420868676 CA355357165	4	P>S		No	ClinGen gnomAD
CA355357160 rs1157202636	5	C>R		No	ClinGen gnomAD
CA355357152 rs1577254408	6	I>V		No	ClinGen Ensembl
rs1408856588 CA355357144	7	S>C		No	ClinGen TOPMed
rs1377908491 CA355357133	8	R>L		No	ClinGen gnomAD
rs1197688594 CA355357132	9	L>M		No	ClinGen gnomAD
CA355357121 rs1487925057	10	C>*		No	ClinGen gnomAD
rs1216655892 CA355357124	10	C>F		No	ClinGen gnomAD
rs1264735499 CA355357127	10	C>R		No	ClinGen gnomAD
rs1216655892 CA355357122	10	C>Y		No	ClinGen gnomAD
CA355357114 rs1220794872	11	C>*		No	ClinGen gnomAD
rs749823342 CA355357115	11	C>F		No	ClinGen ExAC gnomAD
rs749823342 CA2723303	11	C>Y		No	ClinGen ExAC gnomAD
rs1345448060 CA355357112	12	L>M		No	ClinGen gnomAD
rs1275715279 CA355357108	12	L>Q		No	ClinGen gnomAD
CA355357104 rs1300119443	13	A>E		No	ClinGen gnomAD
rs1343828370 CA355357106	13	A>P		No	ClinGen TOPMed gnomAD
CA355357107 rs1343828370	13	A>T		No	ClinGen TOPMed gnomAD
CA355357102 rs1300119443	13	A>V		No	ClinGen gnomAD
rs1316834471 CA355357097	14	R>L		No	ClinGen gnomAD
CA355357100 rs1360508811	14	R>W		No	ClinGen gnomAD
rs1426291178 CA355357096	15	R>C		No	ClinGen gnomAD
CA355357093 rs1172311031	15	R>H		No	ClinGen gnomAD
rs1172311031 CA355357091	15	R>L		No	ClinGen gnomAD
rs1426291178 CA355357094	15	R>S		No	ClinGen gnomAD
rs1193772027 CA355357082	16	W>C		No	ClinGen gnomAD
rs1425245420 CA355357085	16	W>L		No	ClinGen gnomAD
rs1477202337 CA355357080	17	N>D		No	ClinGen gnomAD
CA355357077 rs1240354202	17	N>S		No	ClinGen gnomAD
CA355357071 rs1442885026	18	Q>*		No	ClinGen gnomAD
rs867097085 CA88806391	18	Q>H		No	ClinGen gnomAD
CA355357066 rs1201468733	19	L>M		No	ClinGen gnomAD
rs1321683726 CA355357062	19	L>P		No	ClinGen gnomAD
CA88806375 rs955076767	20	D>G		No	ClinGen TOPMed gnomAD
rs985747743 CA88806389	20	D>H		No	ClinGen TOPMed gnomAD
rs985747743 CA355357061	20	D>Y		No	ClinGen TOPMed gnomAD
rs1029283585 CA88806368	21	R>C		No	ClinGen TOPMed gnomAD
rs1360212745 CA355357053	21	R>H		No	ClinGen gnomAD
CA355357051 rs1360212745	21	R>L		No	ClinGen gnomAD
rs1402096381 CA355357045	22	S>F		No	ClinGen TOPMed gnomAD
rs1468513695 CA355357050	22	S>P		No	ClinGen gnomAD
CA355357047 rs1402096381	22	S>Y		No	ClinGen TOPMed gnomAD
CA355357037 rs1416798490	23	D>E		No	ClinGen gnomAD
rs1464686309 CA355357044	23	D>N		No	ClinGen gnomAD
rs1464686309 CA355357042	23	D>Y		No	ClinGen gnomAD
rs1183056543 CA355357034	24	V>L		No	ClinGen gnomAD
CA355357036 rs1183056543	24	V>M		No	ClinGen gnomAD
rs1473087047 CA355357025	25	A>V		No	ClinGen TOPMed gnomAD
CA355357024 rs1189367126	26	V>M		No	ClinGen TOPMed
rs868388777 CA88806363	27	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1414997547 CA355356993	31	H>P		No	ClinGen TOPMed
rs1260277084 CA355356986	32	G>C		No	ClinGen gnomAD
TCGA novel	34	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1307092103 CA355356958	36	L>F		No	ClinGen gnomAD
rs1230037795 CA355356937	39	E>*		No	ClinGen TOPMed gnomAD
rs1230037795 CA355356938	39	E>Q		No	ClinGen TOPMed gnomAD
rs868078982 CA88806357	41	P>S		No	ClinGen gnomAD
CA355356914 rs1428696298	42	G>D		No	ClinGen TOPMed
CA355356917 rs1314951002	42	G>S		No	ClinGen gnomAD
rs769304543 CA2723301	43	T>M		No	ClinGen ExAC gnomAD
CA88806354 rs961100991	44	G>D		No	ClinGen TOPMed gnomAD
CA355356894 rs1017068925	46	A>S		No	ClinGen TOPMed gnomAD
rs1017068925 CA88806347	46	A>T		No	ClinGen TOPMed gnomAD
CA355356881 rs1166307553	48	S>*		No	ClinGen TOPMed gnomAD
CA355356879 rs1166307553	48	S>L		No	ClinGen TOPMed gnomAD
rs1405429727 CA355356878	49	R>C		No	ClinGen TOPMed gnomAD
CA355356877 rs1405429727	49	R>G		No	ClinGen TOPMed gnomAD
CA88806343 rs1005719253	49	R>L		No	ClinGen TOPMed gnomAD
rs959769906 CA88806337	51	G>R		No	ClinGen TOPMed gnomAD
rs551404235 CA2723300	51	G>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1033968335 CA88806336	53	P>T		No	ClinGen TOPMed gnomAD
CA355356848 rs1238589623	54	P>A		No	ClinGen gnomAD
rs1238589623 CA355356849	54	P>S		No	ClinGen gnomAD
CA355356838 rs1177738658	55	A>V		No	ClinGen gnomAD
CA355356824 rs1560357825	58	R>Q		No	ClinGen Ensembl
rs780698630 CA2723299	58	R>W		No	ClinGen ExAC gnomAD
rs1231340008 CA355356800	62	R>W		No	ClinGen TOPMed gnomAD
rs1322403470 CA355356787	64	V>L		No	ClinGen gnomAD
rs545671364 CA88806300	65	P>Q		No	ClinGen gnomAD
TCGA novel	68	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1448397991 CA355356750	69	Y>*		No	ClinGen TOPMed
CA355356753 rs1577254105	69	Y>C		No	ClinGen Ensembl
CA355356748 rs1042397257	70	Q>*		No	ClinGen TOPMed gnomAD
rs1042397257 CA88806285	70	Q>E		No	ClinGen TOPMed gnomAD
rs1310455905 CA355356738	71	R>L		No	ClinGen gnomAD
CA355356740 rs1310455905	71	R>Q		No	ClinGen gnomAD
CA355356741 rs1356418752	71	R>W		No	ClinGen TOPMed gnomAD
rs1391122161 CA355356737	72	D>N		No	ClinGen gnomAD
rs1370799895 CA355356711	74	G>D		No	ClinGen gnomAD
CA355356714 rs1403266506	74	G>R		No	ClinGen TOPMed
rs1370799895 CA355356708	74	G>V		No	ClinGen gnomAD
CA88806276 rs77515107	75	L>W		No	ClinGen Ensembl
CA355356668 rs1350837763	78	T>A		No	ClinGen TOPMed
rs1294916055 CA355356659	79	P>T		No	ClinGen gnomAD
rs1054241938 CA88806254	83	K>N		No	ClinGen TOPMed gnomAD
rs1364379567 CA355356614	83	K>R		No	ClinGen TOPMed gnomAD
CA355356591 rs1577254041	85	P>L		No	ClinGen Ensembl
CA2723296 rs568881694	86	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA88806241 rs1049706088	86	P>S		No	ClinGen TOPMed gnomAD
CA88806235 rs1049706088	86	P>T		No	ClinGen TOPMed gnomAD
rs758363343 CA2723295	87	P>S		No	ClinGen ExAC gnomAD
rs1246156706 CA355356568	88	G>E		No	ClinGen TOPMed
rs750399591 CA2723294	89	R>C		No	ClinGen ExAC TOPMed gnomAD
CA88806194 rs972388049	90	G>*		No	ClinGen TOPMed
CA355356542 rs1162352794	91	P>S		No	ClinGen TOPMed
rs1414951131 CA355356532	92	G>E		No	ClinGen TOPMed
rs1319001250 CA355356514	94	G>S		No	ClinGen TOPMed
rs1388487338 CA355356493	96	R>C		No	ClinGen TOPMed
CA88806192 rs528962937	98	G>D		No	ClinGen 1000Genomes
rs961007375 CA88806191	99	K>N		No	ClinGen TOPMed
CA355356435 rs1406146908	101	S>F		No	ClinGen gnomAD
CA355356429 rs760667646	102	A>G		No	ClinGen ExAC TOPMed gnomAD
CA2723293 COSM3695937 rs370227160	102	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA2723292 rs760667646	102	A>V		No	ClinGen ExAC TOPMed gnomAD
CA355356410 rs1266032541	104	S>P		No	ClinGen TOPMed
rs1287352837 CA355356382	106	A>V		No	ClinGen gnomAD
rs752878396 CA2723291	107	P>R		No	ClinGen ExAC
CA355356377 rs1315467539	107	P>T		No	ClinGen gnomAD
TCGA novel	108	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355356342 rs1300755220	110	P>L		No	ClinGen TOPMed gnomAD
rs1300755220 CA355356344	110	P>R		No	ClinGen TOPMed gnomAD
rs1186361264 CA355356347	110	P>S		No	ClinGen TOPMed
CA88806159 rs996799680	111	G>D		No	ClinGen Ensembl
CA355356341 rs1361157524	111	G>S		No	ClinGen gnomAD
CA88806152 rs970981446	112	A>P		No	ClinGen TOPMed gnomAD
rs1360663642 CA355356320	113	R>C		No	ClinGen gnomAD
CA355356323 rs1360663642	113	R>S		No	ClinGen gnomAD
CA355356305 rs964325398	114	G>A		No	ClinGen TOPMed
CA88806151 rs964325398	114	G>E		No	ClinGen TOPMed
CA355356313 rs1176461144	114	G>R		No	ClinGen gnomAD
rs1019462828 CA88806146	115	V>I		No	ClinGen TOPMed gnomAD
rs1428784968 CA355356290	116	Y>C		No	ClinGen TOPMed gnomAD
rs1478840611 CA355356280	117	V>E		No	ClinGen gnomAD
rs1197432974 CA355356282	117	V>L		No	ClinGen gnomAD
CA355356281 rs1197432974	117	V>M		No	ClinGen gnomAD
CA355356277 rs1263090362	118	L>M		No	ClinGen gnomAD
rs528408351 CA2723288	119	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771303753 CA355356264	120	I>L		No	ClinGen ExAC gnomAD
CA2723287 rs771303753	120	I>V		No	ClinGen ExAC gnomAD
CA2723285 rs545006671	121	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA355356229 rs1334961531	123	A>S		No	ClinGen TOPMed
rs1357553038 CA355356217	124	D>A		No	ClinGen TOPMed
rs747592296 CA2723283	125	A>T		No	ClinGen ExAC gnomAD
CA88806088 rs1008036778	127	A>P		No	ClinGen TOPMed
CA88806081 rs556401220	130	T>A		No	ClinGen 1000Genomes
CA355356141 rs1380481799	131	T>K		No	ClinGen TOPMed gnomAD
rs1294833422 CA355356146	131	T>S		No	ClinGen gnomAD
CA355356132 rs1303223379	132	S>*		No	ClinGen gnomAD
CA2723268 rs375663308	138	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2723267 rs763296244	139	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2723266 rs552622624	142	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1180858614 CA355355015	142	G>R		No	ClinGen gnomAD
CA355354993 rs1193640815	145	P>L		No	ClinGen gnomAD
rs534835483 CA2723265	145	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA355354991 rs1343824093	146	S>P		No	ClinGen TOPMed
rs762417809 CA2723264	147	R>G		No	ClinGen ExAC gnomAD
CA2723263 rs775959153	147	R>S		No	ClinGen ExAC TOPMed gnomAD
CA2723262 rs768225948	148	S>C		No	ClinGen ExAC gnomAD
rs1311187474 CA355354949	152	K>N		No	ClinGen gnomAD
CA2723261 rs373151457	153	P>A		No	ClinGen ESP ExAC gnomAD
CA2723259 rs771910480	154	A>G		No	ClinGen ExAC gnomAD
rs775278881 CA355354942	154	A>P		No	ClinGen ExAC gnomAD
CA2723260 rs775278881	154	A>T		No	ClinGen ExAC gnomAD
rs570590442 CA2723257	155	R>*		No	ClinGen 1000Genomes ExAC gnomAD
CA2723258 rs570590442	155	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA2723256 rs757103099	155	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs749266192 CA2723255	158	T>A		No	ClinGen ExAC
CA355354919 rs1303785644	158	T>I		No	ClinGen gnomAD
CA2723254 rs137891664	159	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2723251 rs766568506	160	H>P		No	ClinGen ExAC gnomAD
rs751702934 CA2723252	160	H>Y		No	ClinGen ExAC gnomAD
rs750749698 CA2723249	161	T>I		No	ClinGen ExAC gnomAD
rs758662891 CA2723250	161	T>P		No	ClinGen ExAC gnomAD
CA355354900 rs200895198	162	S>*		No	ClinGen ExAC TOPMed gnomAD
CA2723247 rs200895198	162	S>L		No	ClinGen ExAC TOPMed gnomAD
rs764577957 CA2723245	164	W>R		No	ClinGen ExAC gnomAD
rs760250180 CA2723244	166	S>G		No	ClinGen ExAC gnomAD
CA2723243 rs775186756	166	S>T		No	ClinGen ExAC gnomAD
rs771818432 CA2723242	168	P>L		No	ClinGen ExAC gnomAD
rs771818432 CA355354858	168	P>R		No	ClinGen ExAC gnomAD
CA2723241 rs536995855	169	G>V		No	ClinGen 1000Genomes ExAC gnomAD
rs11544780 CA88798168	171	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867410269 CA88798166	171	G>D		No	ClinGen Ensembl
rs11544780 CA2723239	171	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749110009 CA2723238	173	Q>*		No	ClinGen ExAC gnomAD
rs1321617841 CA355354811	175	P>A		No	ClinGen gnomAD
CA355354799 rs1215176025	176	E>D		No	ClinGen gnomAD
rs1275207272 CA355354802	176	E>G		No	ClinGen TOPMed gnomAD
rs766247025 CA88797404	176	E>Q		No	ClinGen Ensembl
CA2723212 rs779184025	177	V>G		No	ClinGen ExAC gnomAD
CA355354797 rs1339371318	177	V>M		No	ClinGen gnomAD
rs1383963637 CA355354791	178	R>K		No	ClinGen gnomAD
rs1336435405 CA355354776	180	K>*		No	ClinGen TOPMed gnomAD
CA355354773 rs1450050668	180	K>M		No	ClinGen TOPMed gnomAD
rs1170551995 CA355354754	183	P>S		No	ClinGen gnomAD
CA355354741 rs1408851698	185	P>A		No	ClinGen TOPMed gnomAD
CA355354740 rs1408851698	185	P>S		No	ClinGen TOPMed gnomAD
CA355354742 rs1408851698	185	P>T		No	ClinGen TOPMed gnomAD
CA355354732 rs1347233400	186	S>C		No	ClinGen TOPMed
CA88797349 rs867682635	187	A>T		No	ClinGen TOPMed gnomAD
rs1242333776 CA355354725	188	I>L		No	ClinGen gnomAD
rs1257926738 CA355354709	190	Q>K		No	ClinGen gnomAD
rs1181446978 CA355354696	191	A>V		No	ClinGen gnomAD
rs1234799977 CA355354689	192	S>L		No	ClinGen TOPMed gnomAD
CA355354677 rs1205390920	193	A>V		No	ClinGen gnomAD
rs62285797 CA88797340	194	P>L		No	ClinGen gnomAD
rs1437285588 CA355354675	194	P>T		No	ClinGen TOPMed gnomAD
rs778312659 CA355354656	195	R>P		No	ClinGen ExAC TOPMed gnomAD
rs778312659 CA2723209	195	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs754196904 CA2723210	195	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1314802106 CA355354651	196	I>V		No	ClinGen gnomAD
rs1244167232 CA355354637	197	L>I		No	ClinGen gnomAD
rs756638893 CA2723208	199	V>M		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q9H9H5

No regional properties for Q9H9H5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9H9H5

Functions

		Description
EC Number
Subcellular Localization	Golgi apparatus Cytoplasm, cytoskeleton	Colocalizes with microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cis-Golgi network	The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
Golgi-associated vesicle	Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

2 GO annotations of molecular function

Name	Definition
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

5 GO annotations of biological process

Name	Definition
cytoskeleton-dependent intracellular transport	The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
N-terminal peptidyl-L-cysteine N-palmitoylation	The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine.
negative regulation of microtubule depolymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
regulation of microtubule cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAWPCISRLC	CLARRWNQLD	RSDVAVPLTL	HGYSDLDSEE	PGTGGAASRR	GQPPAGARDS
70	80	90	100	110	120
GRDVPLTQYQ	RDFGLWTTPA	GPKDPPPGRG	PGAGGRRGKS	SAQSSAPPAP	GARGVYVLPI
130	140	150	160	170	180
GDADAAAAVT	TSYRQEFQAW	TGVKPSRSTK	TKPARVITTH	TSGWDSSPGA	GFQVPEVRKK
190
FTPNPSAIFQ	ASAPRILNV