AiPD: Autoinhibited Protein Database

Q9H773

Gene name	DCTPP1
Protein name	dCTP pyrophosphatase 1
Names	Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated gene A protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79077
EC number	3.6.1.12: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-50 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9H773

Entry ID	Method	Resolution	Chain	Position	Source
7MU5	X-ray	220 A	A/B/C/D/E/F/G/H	21-130	PDB
AF-Q9H773-F1	Predicted				AlphaFoldDB

153 variants for Q9H773

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA8005744 rs754320814	2	S>F		No	ClinGen ExAC TOPMed
rs764625693 CA8005743	4	A>V		No	ClinGen ExAC gnomAD
rs202172957 CA8005741	5	G>V		No	ClinGen 1000Genomes ExAC gnomAD
rs200319978 CA8005739	6	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1378308334 CA395596826	6	G>R		No	ClinGen gnomAD
rs773060140 CA280509701	8	I>F		No	ClinGen ExAC TOPMed gnomAD
rs773060140 CA8005738	8	I>V		No	ClinGen ExAC TOPMed gnomAD
CA395596759 rs1319311823	9	R>L		No	ClinGen TOPMed gnomAD
CA8005736 rs761452897	11	D>A		No	ClinGen ExAC gnomAD
CA8005735 rs776316015	12	T>A		No	ClinGen ExAC TOPMed gnomAD
CA395596703 rs1161700941	12	T>M		No	ClinGen gnomAD
CA395596694 rs543674443	13	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs543674443 CA395596689	13	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8005732 rs201197422 CA8005733	13	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs543674443 CA8005730	13	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201197422 CA8005731	13	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs977028957 CA395596676	14	G>*		No	ClinGen TOPMed gnomAD
COSM184995 CA395596673 rs1246195315	14	G>E	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs977028957 CA280509662	14	G>R		No	ClinGen TOPMed gnomAD
CA280509657 rs965450062	15	E>A		No	ClinGen TOPMed
CA395596621 rs1219103702	16	D>E		No	ClinGen gnomAD
CA395596633 rs1270297565	16	D>N		No	ClinGen gnomAD
rs757295928 CA8005728	17	T>P		No	ClinGen ExAC TOPMed gnomAD
CA8005727 rs749322219	18	A>P		No	ClinGen ExAC gnomAD
rs753147370 CA8005725	19	A>G		No	ClinGen ExAC TOPMed gnomAD
CA8005726 rs777848541	19	A>P		No	ClinGen ExAC gnomAD
rs753147370 CA8005724	19	A>V		No	ClinGen ExAC TOPMed gnomAD
CA395596553 rs1435252347	20	P>S		No	ClinGen gnomAD
CA395596525 rs369621327	22	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs369621327 CA8005722	22	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8005723 rs781610165	22	R>W		No	ClinGen ExAC gnomAD
CA395596514 rs1597039479	23	F>V		No	ClinGen Ensembl
rs1434474683 CA395596487	24	S>T		No	ClinGen TOPMed gnomAD
CA395596425 rs1165933243	27	P>L		No	ClinGen gnomAD
rs1165933243 CA395596426	27	P>R		No	ClinGen gnomAD
rs1334334770 CA395596408	29	P>A		No	ClinGen TOPMed
rs761580953 CA8005718	29	P>L		No	ClinGen ExAC gnomAD
rs761580953 CA8005719	29	P>R		No	ClinGen ExAC gnomAD
rs753342612 CA8005716	32	E>K		No	ClinGen ExAC gnomAD
CA395596330 rs1189635625	34	I>V		No	ClinGen gnomAD
CA8005696 rs753614679	35	R>C		No	ClinGen ExAC TOPMed gnomAD
CA395595717 rs1287281200	35	R>H		No	ClinGen TOPMed
rs897492409 CA280509219	36	R>H		No	ClinGen TOPMed gnomAD
rs760150137 CA8005694	39	A>T		No	ClinGen ExAC gnomAD
CA8005693 rs752645482	39	A>V		No	ClinGen ExAC gnomAD
rs1399291233 CA395595633	40	E>V		No	ClinGen gnomAD
CA8005691 rs759492520	43	A>G		No	ClinGen ExAC gnomAD
TCGA novel	43	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8005692 rs759492520	43	A>V		No	ClinGen ExAC gnomAD
CA395595570 rs1405225469	44	E>*		No	ClinGen Ensembl
CA8005688 rs763156020	44	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	44	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8005687 rs773357649	47	W>*		No	ClinGen ExAC gnomAD
CA395595445 rs1567445829	50	F>C		No	ClinGen Ensembl
TCGA novel	50	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8005681 rs747527404	54	R>G		No	ClinGen ExAC gnomAD
CA395595374 rs780565157	54	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8005680 rs780565157	54	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs747527404 CA8005682 COSM293122	54	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA395595271 rs1328087150	61	V>A		No	ClinGen TOPMed gnomAD
CA395595259 rs1229452964	62	G>E		No	ClinGen gnomAD
rs1311298276 CA395595251	63	E>K		No	ClinGen gnomAD
rs200511564 CA8005675	65	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs551316027 CA8005674	66	E>K		No	ClinGen ExAC gnomAD
rs1471062237 CA395595151	70	L>I		No	ClinGen gnomAD
rs1376450766 CA395595134	71	F>L		No	ClinGen gnomAD
CA8005639 rs760875327	71	F>L		No	ClinGen ExAC gnomAD
CA8005672 rs754842539	71	F>S		No	ClinGen ExAC TOPMed
rs775739171 CA8005638	74	K>T		No	ClinGen ExAC gnomAD
CA395594243 rs1490634992	75	T>A		No	ClinGen gnomAD
CA280507369 rs546895092	76	D>N		No	ClinGen 1000Genomes TOPMed
CA8005637 rs374212967	80	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs746395697 CA8005636	81	P>L		No	ClinGen ExAC gnomAD
CA8005634 rs771392941	82	Q>H		No	ClinGen ExAC gnomAD
rs902778856 CA280507352	83	G>D		No	ClinGen TOPMed
rs1597036193 CA395594083	85	S>C		No	ClinGen Ensembl
rs780869586 CA8005632	86	P>T		No	ClinGen ExAC gnomAD
CA8005629 rs779554157	88	E>K		No	ClinGen ExAC gnomAD
CA395594025 rs1401049051	89	R>Q		No	ClinGen gnomAD
CA8005627 rs150574437	89	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1172860792 CA395594003	90	A>V		No	ClinGen gnomAD
TCGA novel	91	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8005624 rs753978195	93	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs371070247 CA8005625	93	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1311936075 CA395593929	95	E>*		No	ClinGen TOPMed
CA395593919 rs1234004932	95	E>D		No	ClinGen gnomAD
rs1206708246 CA395593910	96	L>F		No	ClinGen gnomAD
TCGA novel	99	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8005622 rs368588932	99	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1567444359 CA395593824	101	I>F		No	ClinGen Ensembl
CA395593804 rs1597036137	102	Y>S		No	ClinGen Ensembl
CA8005621 rs752763022	104	V>M		No	ClinGen ExAC TOPMed gnomAD
rs199517315 CA8005620	109	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs549109262 CA8005619	109	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8005618 rs143083714	111	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA8005616 rs373815836	111	R>H		No	ClinGen ESP TOPMed gnomAD
TCGA novel	111	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8005615 rs771175722	112	V>E		No	ClinGen ExAC TOPMed gnomAD
CA8005613 rs773589795	113	D>A		No	ClinGen ExAC gnomAD
CA8005614 rs370140300	113	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs376877902 CA8005612	115	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs746669962 CA8005611 COSM122527	115	P>L	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs771674751 CA8005609	116	L>P		No	ClinGen ExAC gnomAD
rs961928311 CA280507295	118	V>A		No	ClinGen Ensembl
rs778952081 CA8005607	119	L>P		No	ClinGen ExAC gnomAD
rs753635115 CA8005605	122	M>I		No	ClinGen ExAC gnomAD
CA8005604 rs777720974	123	D>N		No	ClinGen ExAC gnomAD
rs1401805447 CA395593478	125	N>D		No	ClinGen TOPMed
CA8005601 rs767691169	126	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs753034750 CA8005602	126	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8005600 rs544521264	127	R>*		No	ClinGen 1000Genomes ExAC gnomAD
CA8005599 rs751978200	127	R>Q		No	ClinGen ExAC gnomAD
rs1014862414 CA280507277	128	R>C		No	ClinGen TOPMed gnomAD
rs766861882 CA8005598	128	R>H		No	ClinGen ExAC gnomAD
rs1315109042 CA395593420	129	Y>F		No	ClinGen gnomAD
CA395593429 rs1378378183	129	Y>H		No	ClinGen gnomAD
rs1362573471 CA395593395	131	A>P		No	ClinGen gnomAD
CA280507268 rs1010468456	135	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA395593347 rs1010468456	135	R>G		No	ClinGen TOPMed gnomAD
rs985136446 CA8005596	135	R>H		No	ClinGen TOPMed gnomAD
rs985136446 CA395593344	135	R>L		No	ClinGen TOPMed gnomAD
CA8005595 rs372874656	137	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs951901812 CA280507261	137	S>F		No	ClinGen TOPMed gnomAD
CA8005594 rs147236122	139	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8005592 rs143856356	139	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8005591 rs143856356	139	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143856356 CA8005593	139	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1446593643 CA395593319	140	K>R		No	ClinGen gnomAD
CA8005589 rs148153979	141	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8005590 rs148153979	141	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA8005587 rs770841070	142	T>I		No	ClinGen ExAC gnomAD
CA8005588 rs770841070	142	T>R		No	ClinGen ExAC gnomAD
CA395593259 rs1243582830	145	P>L		No	ClinGen gnomAD
CA8005585 rs777702703	146	H>Q		No	ClinGen ExAC gnomAD
CA395593247 rs1219167590	146	H>R		No	ClinGen TOPMed gnomAD
rs1247513963 CA395593211	148	A>G		No	ClinGen gnomAD
CA8005583 rs748357337	150	S>C		No	ClinGen ExAC gnomAD
TCGA novel	151	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	151	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395593150 rs1296228600	153	Q>E		No	ClinGen gnomAD
CA280507219 rs372655566	153	Q>R		No	ClinGen Ensembl
rs1214750105 CA395593126	154	A>V		No	ClinGen gnomAD
rs780559590 CA280507213	155	V>M		No	ClinGen gnomAD
rs146094440 CA8005582	156	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149017773 CA8005581	158	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395593051 rs1304343543	159	D>E		No	ClinGen gnomAD
rs1346504633 CA395593012	162	C>Y		No	ClinGen TOPMed
rs758941195 CA8005578	165	T>I		No	ClinGen ExAC gnomAD
rs750990261 CA8005577	166	G>D		No	ClinGen ExAC gnomAD
rs11541539 CA280507198	166	G>R		No	ClinGen Ensembl
CA395592968 rs1429313087	168	T>I		No	ClinGen gnomAD
rs201992231 CA8005575	169	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs777014870 CA8005574	171	T>W		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q9H773

No regional properties for Q9H773

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9H773

Functions

		Description
EC Number	3.6.1.12	In phosphorus-containing anhydrides
Subcellular Localization	Mitochondrion Nucleus Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
dCTP diphosphatase activity	Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate.
identical protein binding	Binding to an identical protein or proteins.
magnesium ion binding	Binding to a magnesium (Mg) ion.
nucleoside triphosphate diphosphatase activity	Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.
pyrimidine deoxyribonucleotide binding	Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.

3 GO annotations of biological process

Name	Definition
dCTP catabolic process	The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate.
DNA protection	Any process in which DNA is protected from damage by, for example, oxidative stress.
nucleoside triphosphate catabolic process	The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSVAGGEIRG	DTGGEDTAAP	GRFSFSPEPT	LEDIRRLHAE	FAAERDWEQF	HQPRNLLLAL
70	80	90	100	110	120
VGEVGELAEL	FQWKTDGEPG	PQGWSPRERA	ALQEELSDVL	IYLVALAARC	RVDLPLAVLS
130	140	150	160
KMDINRRRYP	AHLARSSSRK	YTELPHGAIS	EDQAVGPADI	PCDSTGQTST