AiPD: Autoinhibited Protein Database

Q9H4Z3

Gene name	PCIF1
Protein name	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Names	Cap-specific adenosine methyltransferase, CAPAM, hCAPAM, Phosphorylated CTD-interacting factor 1, hPCIF1, Protein phosphatase 1 regulatory subunit 121
Species	Homo sapiens (Human)
KEGG Pathway	hsa:63935
EC number	2.1.1.62: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-51 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9H4Z3

Entry ID	Method	Resolution	Chain	Position	Source
2JX8	NMR	-	A	40-86	PDB
6IRV	X-ray	270 A	A/B	174-672	PDB
6IRW	X-ray	290 A	A/B	174-672	PDB
AF-Q9H4Z3-F1	Predicted				AlphaFoldDB

491 variants for Q9H4Z3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1455639158 CA409213564	2	A>V		No	ClinGen gnomAD
CA409213567 rs1194343287	3	N>D		No	ClinGen TOPMed gnomAD
CA9884070 rs775884705	3	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	4	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1438088074 CA409213632	6	H>N		No	ClinGen gnomAD
CA9884072 rs769186115	7	G>S		No	ClinGen ExAC TOPMed gnomAD
CA409213687 rs1198784331	8	S>I		No	ClinGen TOPMed
rs201439678 CA9884074 CA409213690	8	S>R		No	ClinGen ExAC TOPMed gnomAD
rs914610981 CA315632552	9	P>S		No	ClinGen Ensembl
CA9884076 rs530025799	10	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA315632563 rs979221783	10	R>P		No	ClinGen gnomAD
CA409213719 rs979221783	10	R>Q		No	ClinGen gnomAD
rs530025799 CA9884075	10	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9884078 rs763290934	11	E>Q		No	ClinGen ExAC
rs1202358951 CA409213788	13	A>V		No	ClinGen TOPMed
TCGA novel	14	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884080 rs200252509	16	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA9884082 rs148051478	17	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs753323794 CA9884083	18	H>P		No	ClinGen ExAC gnomAD
rs778545268 CA9884085	18	H>Q		No	ClinGen ExAC gnomAD
CA9884084 rs753323794	18	H>R		No	ClinGen ExAC gnomAD
CA9884088 rs780358533	24	N>H		No	ClinGen ExAC TOPMed gnomAD
rs141989652 CA9884089	24	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	25	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409214057 rs1171308250	27	Q>E		No	ClinGen gnomAD
CA9884090 rs769097763	27	Q>H		No	ClinGen ExAC gnomAD
rs777123317 CA9884091	28	P>S		No	ClinGen ExAC gnomAD
rs1056183112 CA315632636	29	C>R		No	ClinGen Ensembl
CA9884092 rs762446521	31	P>S		No	ClinGen ExAC gnomAD
CA9884094 rs773388891	34	I>S		No	ClinGen ExAC gnomAD
rs147107115 CA9884093	34	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884095 rs763052845	35	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9884096 rs767144550	35	R>H		No	ClinGen ExAC TOPMed gnomAD
CA315632666 rs767144550	35	R>L		No	ClinGen ExAC TOPMed gnomAD
CA409214235 rs767144550	35	R>P		No	ClinGen ExAC TOPMed gnomAD
rs752490933 CA9884097	38	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA409214289 rs1443811701	38	Q>H		No	ClinGen gnomAD
CA9884098 rs371070082	41	P>S		No	ClinGen ESP ExAC gnomAD
rs375497874 CA9884119	42	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs199747773 CA315632814	46	H>L		No	ClinGen 1000Genomes
rs199747773 CA315632798	46	H>R		No	ClinGen 1000Genomes
CA409214600 rs1216358057	47	A>T		No	ClinGen TOPMed gnomAD
CA9884121 rs147747748	50	E>Q		No	ClinGen ESP ExAC gnomAD
rs1259107205 CA409214706	51	K>R		No	ClinGen gnomAD
TCGA novel	53	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311720181 CA409214761	53	W>L		No	ClinGen gnomAD
COSM1242638 rs1208251025 CA409214824	55	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
CA315632830 COSM3799589 rs531224212	59	R>C	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1485871983 CA409214942	60	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9884123 rs749849155	62	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA315632838 rs923767404	63	F>Y		No	ClinGen gnomAD
rs988222969 CA315632849	64	N>S		No	ClinGen TOPMed
TCGA novel	65	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs956634989 CA315632868	65	R>Q		No	ClinGen gnomAD
rs781378398 CA9884128 CA409215389	74	M>I		No	ClinGen ExAC gnomAD
rs1175125872 CA409215402	75	P>S		No	ClinGen gnomAD
rs749878103 CA9884132	76	V>G		No	ClinGen ExAC TOPMed gnomAD
rs764558584 CA409215423	76	V>L		No	ClinGen ExAC TOPMed gnomAD
rs764558584 CA9884131	76	V>M		No	ClinGen ExAC TOPMed gnomAD
CA409215445 rs1343911614	77	L>P		No	ClinGen gnomAD
rs1236582407 CA409215498	81	D>N		No	ClinGen TOPMed
rs745971471 CA9884153	84	S>A		No	ClinGen ExAC gnomAD
rs772130243 CA9884154	84	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9884155 rs780331537	91	A>V		No	ClinGen ExAC TOPMed gnomAD
CA409216189 rs1479500254	94	L>R		No	ClinGen TOPMed
rs1327023387 CA409216195	95	P>R		No	ClinGen gnomAD
rs769615379 CA9884157	96	Q>R		No	ClinGen ExAC gnomAD
rs1568792182 CA409216210	97	D>E		No	ClinGen Ensembl
rs1223523341 CA409216232	101	V>M		No	ClinGen TOPMed
rs976362831 CA315633802	102	E>D		No	ClinGen TOPMed gnomAD
rs377164917 CA315633825	103	T>N		No	ClinGen ESP TOPMed
rs777519257 CA9884159	103	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1273801369 CA409216253	104	P>H		No	ClinGen gnomAD
CA409216252 rs1273801369	104	P>L		No	ClinGen gnomAD
CA409216260 rs1193575163	105	P>L		No	ClinGen TOPMed gnomAD
CA9884160 rs770884917	108	N>K		No	ClinGen ExAC gnomAD
CA9884161 rs773800076	111	R>G		No	ClinGen ExAC gnomAD
CA409216299 rs1237231691	111	R>K		No	ClinGen gnomAD
CA9884162 rs188509769	113	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1275804988 CA409216311	113	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs148361036 CA9884164	116	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884163 rs115906516	116	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1297235902 CA409216346	118	E>D		No	ClinGen TOPMed
CA409216340 rs1398859253	118	E>K		No	ClinGen gnomAD
rs1410719400 CA409216363	121	S>G		No	ClinGen gnomAD
rs1416463497 CA409216373	122	G>D		No	ClinGen gnomAD
rs1353319988 CA409216370	122	G>S		No	ClinGen gnomAD
CA9884166 rs764489815	123	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1339772735 CA409216385	124	G>C		No	ClinGen gnomAD
rs1252583151 CA409216389	125	V>M		No	ClinGen gnomAD
CA409216399 rs1174201455	126	K>R		No	ClinGen TOPMed
CA409216411 rs1339529960	128	P>A		No	ClinGen gnomAD
CA409216418 rs1199504499	129	K>E		No	ClinGen gnomAD
CA409216440 rs1308156442	130	I>T		No	ClinGen gnomAD
rs778730135 CA9884199	130	I>V		No	ClinGen ExAC gnomAD
rs771936045 CA9884201	134	V>M		No	ClinGen ExAC gnomAD
rs775018048 CA9884202	135	T>I		No	ClinGen ExAC gnomAD
rs1469916053 CA409216474	136	P>S		No	ClinGen gnomAD
rs1194489027 CA409216481	137	T>A		No	ClinGen gnomAD
rs45443494 CA9884204	137	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA315634111 rs917498104	139	Q>H		No	ClinGen TOPMed gnomAD
CA409216497 rs1161051060	139	Q>R		No	ClinGen gnomAD
CA9884206 rs761620079	140	S>L		No	ClinGen ExAC TOPMed gnomAD
CA315634137 rs930604468	145	P>S		No	ClinGen TOPMed
CA9884210 rs766815352	146	S>I		No	ClinGen ExAC gnomAD
rs755015991 CA9884212	148	P>A		No	ClinGen ExAC gnomAD
rs369147617 CA9884213	150	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs369147617 CA9884214	150	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA409216672 rs1296181752	151	P>L		No	ClinGen TOPMed
rs778640382 CA315634173	152	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs367938445 CA9884217	152	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884216 rs778640382	152	T>S		No	ClinGen ExAC TOPMed gnomAD
rs779862839 CA9884219	153	L>P		No	ClinGen ExAC gnomAD
TCGA novel	154	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747038061 CA9884220	155	M>T		No	ClinGen ExAC gnomAD
rs144795164 CA9884222	159	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1185708903 CA409216827	160	P>L		No	ClinGen gnomAD
CA9884224 rs769598596	163	K>N		No	ClinGen ExAC TOPMed gnomAD
rs371513868 CA9884225	169	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs763238295 CA9884226	169	L>P		No	ClinGen ExAC gnomAD
rs907941741 CA315634199	170	R>Q		No	ClinGen TOPMed gnomAD
CA9884253 rs766061514	174	V>I		No	ClinGen ExAC TOPMed gnomAD
CA9884255 rs199768942	175	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs199768942 CA9884254	175	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884258 rs755682740	183	N>S		No	ClinGen ExAC gnomAD
rs748870221 CA9884260	186	I>M		No	ClinGen ExAC TOPMed gnomAD
CA9884259 rs146019196	186	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9884261 rs574698419	187	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1024473250 CA315634432	189	R>Q		No	ClinGen gnomAD
rs370069756 CA9884262	189	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1438950855 CA409217596	190	G>R		No	ClinGen gnomAD
rs972081381 CA315634433	193	E>Q		No	ClinGen gnomAD
rs1222999981 CA409217765	197	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs541723930 CA9884265	198	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA409217794 rs1215831482	199	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM368134 CA9884267 rs768592278	200	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	202	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195107800 CA409217855	202	E>K		No	ClinGen gnomAD
TCGA novel	205	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409217958 rs1176324013	206	S>A		No	ClinGen TOPMed
rs960520541 CA315634443	208	L>F		No	ClinGen TOPMed gnomAD
rs1402916554 CA409218126	213	R>W		No	ClinGen gnomAD
CA409218145 rs1160612736	214	Q>R		No	ClinGen gnomAD
rs774233890 CA9884271	215	H>R		No	ClinGen ExAC gnomAD
CA315634448 rs141904891	217	R>W		No	ClinGen ESP TOPMed gnomAD
CA9884273 rs767488854	218	E>D		No	ClinGen ExAC gnomAD
CA409218508 COSM1412111 rs1180325013	223	R>*	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA409218500 rs1180325013	223	R>G		No	ClinGen TOPMed
CA9884274 rs752670637	224	E>G		No	ClinGen ExAC
CA409219834 rs1193699686	230	R>Q		No	ClinGen gnomAD
CA409219823 rs1338232741	230	R>W		No	ClinGen TOPMed gnomAD
CA409219983 rs1484201779	235	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	240	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409220184 rs1257370620	242	V>L		No	ClinGen gnomAD
CA315637069 rs56007236	254	N>S		No	ClinGen Ensembl
CA315637070 rs565847900	256	E>D		No	ClinGen 1000Genomes gnomAD
CA409220746 rs1440157415	257	P>S		No	ClinGen gnomAD
TCGA novel	263	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421934984 CA409220877	263	M>T		No	ClinGen gnomAD
rs144543839 CA9884298	264	F>L		No	ClinGen ESP ExAC gnomAD
CA9884299 rs750052866	265	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA409220979 rs1373444161	265	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA409221071 rs148464921	269	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs868647350 CA315637100	272	P>L		No	ClinGen Ensembl
rs1334814143	273	I>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA9884316 rs764692730	276	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	277	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884317 rs376609010	277	R>Q		No	ClinGen ESP ExAC gnomAD
rs762540613 CA9884318	278	I>V		No	ClinGen ExAC gnomAD
CA409221441 rs1350625696	280	F>L		No	ClinGen gnomAD
rs1203933146 CA409221457	281	R>Q		No	ClinGen gnomAD
CA9884320 rs751808254	282	E>D		No	ClinGen ExAC gnomAD
CA9884321 rs755368530	286	R>H		No	ClinGen ExAC gnomAD
CA409221607 rs755368530	286	R>L		No	ClinGen ExAC gnomAD
rs749402768 CA9884326	292	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
TCGA novel	295	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884329 rs746131827	297	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	299	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884330 rs768473040	300	E>D		No	ClinGen ExAC gnomAD
CA9884344 rs757398067	303	S>G		No	ClinGen ExAC gnomAD
rs1415310936 CA409222055	303	S>N		No	ClinGen gnomAD
CA9884345 rs778906689	303	S>R		No	ClinGen ExAC TOPMed gnomAD
CA409222069 rs1169222709	304	A>T		No	ClinGen gnomAD
rs1428167430 CA409222096	305	S>Y		No	ClinGen gnomAD
rs868159177 CA315637441	306	P>T		No	ClinGen Ensembl
CA409222150 rs758576575	307	D>E		No	ClinGen ExAC gnomAD
rs1371604700 CA409222180	308	S>N		No	ClinGen gnomAD
rs1600507302 CA409222246	311	V>G		No	ClinGen Ensembl
TCGA novel	312	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409222256 rs1600507311	312	V>G		No	ClinGen Ensembl
rs867140307 CA315637443	319	T>N		No	ClinGen Ensembl
CA315637445 rs769531835	321	S>C		No	ClinGen Ensembl
rs1381424104 CA409222541	323	L>F		No	ClinGen gnomAD
rs1228976852 CA409222588	324	R>W		No	ClinGen gnomAD
CA409222595 rs1295061768	325	K>E		No	ClinGen gnomAD
CA9884348 rs780987596	326	D>A		No	ClinGen ExAC gnomAD
CA315637461 rs368177657	327	H>Q		No	ClinGen Ensembl
CA315637449 rs989746518	327	H>Y		No	ClinGen gnomAD
CA315637465 rs867748130	328	S>*		No	ClinGen Ensembl
CA315637471 rs994412496	335	M>L		No	ClinGen TOPMed gnomAD
rs1164254120 CA409222849	335	M>T		No	ClinGen TOPMed
CA409222835 rs994412496	335	M>V		No	ClinGen TOPMed gnomAD
TCGA novel	337	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884370 rs770807664	338	L>P		No	ClinGen ExAC gnomAD
CA409224108 rs1330548775	339	E>D		No	ClinGen TOPMed gnomAD
rs773863031 CA9884371	340	H>Y		No	ClinGen ExAC gnomAD
rs1038747056 CA315638086	342	R>Q		No	ClinGen Ensembl
rs369406590 CA409224176	342	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884375 rs140261212	343	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1478597916 CA409224198	344	Q>*		No	ClinGen TOPMed gnomAD
rs777163266 CA9884377	344	Q>H		No	ClinGen ExAC gnomAD
rs1473583710 CA409224302	346	G>S		No	ClinGen gnomAD
CA315638125 rs1043486085	349	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9884381 rs200586895	350	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409224473 rs1352289165	352	A>T	Variant assessed as Somatic; 4.639e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9884383 rs751760468	353	A>V		No	ClinGen ExAC gnomAD
rs755236165 CA9884384	354	K>R		No	ClinGen ExAC gnomAD
CA9884385 rs777505126	355	D>V		No	ClinGen ExAC gnomAD
rs1191212553 CA409224712	357	V>A		No	ClinGen TOPMed
CA9884388 rs778720816	359	G>A		No	ClinGen ExAC gnomAD
CA409224752 rs1250201815	359	G>S		No	ClinGen gnomAD
CA409224894 rs111673733	364	I>M		No	ClinGen TOPMed
rs1417237689 CA409224977	366	H>R		No	ClinGen TOPMed gnomAD
TCGA novel	368	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768442102 CA9884393	372	V>I		No	ClinGen ExAC gnomAD
rs777073326 CA9884394	373	K>R		No	ClinGen ExAC TOPMed gnomAD
rs748898720 COSM317858 CA9884395	374	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA409225139 rs1372233186	374	R>W		No	ClinGen gnomAD
rs1312269387 CA409225171	375	I>M		No	ClinGen gnomAD
CA409225177 COSM3799591 rs1370088899	376	R>Q	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA9884396 rs770264486	377	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1225779553 CA409225360	384	K>R		No	ClinGen gnomAD
CA409225428 rs1310186560	388	I>V		No	ClinGen TOPMed
CA9884398 rs763566112	389	S>P		No	ClinGen ExAC gnomAD
CA315638744 rs79267277	391	E>A		No	ClinGen ExAC TOPMed gnomAD
CA9884423 rs79267277	391	E>V		No	ClinGen ExAC TOPMed gnomAD
rs764898733 CA9884425	392	V>M		No	ClinGen ExAC gnomAD
TCGA novel	392	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1210144899 CA409225649	393	E>G		No	ClinGen TOPMed
CA9884426 rs750251000	394	A>T		No	ClinGen ExAC gnomAD
TCGA novel	394	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766419767 CA9884428	395	P>L		No	ClinGen ExAC TOPMed gnomAD
CA409225727 rs1328497512	397	V>A		No	ClinGen gnomAD
rs1206924220 CA409225760	399	P>S		No	ClinGen gnomAD
rs751610477 CA9884429	400	R>C		No	ClinGen ExAC gnomAD
rs534457876 CA9884431 COSM254888	400	R>H	Variant assessed as Somatic; 0.0 impact. endometrium urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs534457876 CA9884430	400	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755824857 CA9884433	403	Y>D		No	ClinGen ExAC gnomAD
rs777951768 CA9884434	405	Y>C		No	ClinGen ExAC gnomAD
CA9884435 rs749678896	407	V>L		No	ClinGen ExAC gnomAD
rs774835563 CA9884437	408	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs771361221 CA9884436	408	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1291495439 CA409225946	409	L>V		No	ClinGen gnomAD
CA409225964 rs1388941075	410	A>V		No	ClinGen gnomAD
CA315638782 rs979765623	411	V>L		No	ClinGen TOPMed
CA409225965 rs979765623	411	V>M		No	ClinGen TOPMed
CA315638790 rs956591168	412	S>F		No	ClinGen TOPMed gnomAD
rs373992911 CA9884440	414	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884439 rs772109061	414	P>S		No	ClinGen ExAC gnomAD
rs971297584 CA315638818	416	M>I		No	ClinGen TOPMed gnomAD
rs1194623575 CA409226064	416	M>T		No	ClinGen Ensembl
rs1290263337 CA409226057	416	M>V		No	ClinGen gnomAD
rs1244329405 CA409226071	417	P>R		No	ClinGen gnomAD
rs1263910733 CA409226078	418	S>G		No	ClinGen gnomAD
CA9884442 rs764387553	418	S>N		No	ClinGen ExAC gnomAD
rs762832749 CA9884444	419	V>L		No	ClinGen ExAC
CA409226085 rs762832749	419	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs1482015432 CA409226101	420	E>Q		No	ClinGen gnomAD
COSM3799592 rs751523984 CA9884446	421	M>I	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC
CA409226141 rs1184330769	422	H>Q		No	ClinGen gnomAD
CA9884447 rs755008191	423	M>V		No	ClinGen ExAC TOPMed gnomAD
rs752277469 CA9884449	427	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9884450 rs755665719	428	V>I		No	ClinGen ExAC gnomAD
CA409226270 rs1459728948	429	C>G		No	ClinGen gnomAD
CA9884451 rs777487332	429	C>Y		No	ClinGen ExAC gnomAD
rs757606488 CA9884453	430	I>T		No	ClinGen ExAC gnomAD
rs746332694 CA9884455	431	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9884454 rs779288740	431	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9884457 rs775372767	432	Y>C		No	ClinGen ExAC gnomAD
rs772588812 CA9884456	432	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1181545356 CA409226382	434	G>A		No	ClinGen TOPMed gnomAD
rs1482229586 CA409226368	434	G>R		No	ClinGen gnomAD
rs1273625049 CA409226485	438	K>N		No	ClinGen gnomAD
CA409226498 rs1339883894	439	V>A		No	ClinGen gnomAD
TCGA novel	440	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884458 rs747113490	441	R>C		No	ClinGen ExAC gnomAD
CA9884459 rs377028795	441	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884460 rs776895927	442	N>H		No	ClinGen ExAC TOPMed gnomAD
CA315638839 rs1040982891	444	F>L		No	ClinGen TOPMed
CA9884461 rs150279716	444	F>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755586125 CA315638847	445	S>R		No	ClinGen Ensembl
rs1325855123 CA409226887	449	L>F		No	ClinGen TOPMed
CA409226927 rs1437593130	450	L>P		No	ClinGen gnomAD
rs775486529 CA9884486	452	R>C		No	ClinGen ExAC TOPMed gnomAD
rs145800939 CA9884487 COSM1412113	452	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA9884488 rs763618874	454	S>G		No	ClinGen ExAC gnomAD
rs1024591644 CA315638995	455	C>S		No	ClinGen Ensembl
rs968994794 CA315638998	456	I>T		No	ClinGen gnomAD
rs1312206535 CA409227057	456	I>V		No	ClinGen TOPMed gnomAD
rs772557766 CA315639003	457	D>A		No	ClinGen Ensembl
CA9884491 rs764873141	459	S>C		No	ClinGen ExAC gnomAD
TCGA novel	459	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409227150 rs1243042999	460	A>T		No	ClinGen gnomAD
CA9884492 rs750139303	462	E>A		No	ClinGen ExAC TOPMed gnomAD
CA315639016 rs866453872	463	R>K		No	ClinGen Ensembl
CA409227264 rs1427893672	464	F>L		No	ClinGen gnomAD
TCGA novel	466	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158475249 CA409227349	467	R>Q		No	ClinGen gnomAD
rs1480781914 CA409227334	467	R>W		No	ClinGen gnomAD
rs375088936 CA409227354	468	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375088936 CA9884495	468	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA315639024 rs372740628 COSM1219732	473	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP
rs748255307 CA9884498	473	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9884499 rs770075127	474	R>W		No	ClinGen ExAC gnomAD
TCGA novel	476	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143690590 CA9884522	477	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1600509773 CA409227792	478	M>I		No	ClinGen Ensembl
rs921273704 CA315639134	478	M>T		No	ClinGen gnomAD
CA9884524 rs369393661	481	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1484051183 CA409227906	482	G>A		No	ClinGen gnomAD
CA409227952 rs1182665985	484	Y>C		No	ClinGen TOPMed gnomAD
CA315639150 rs11551743	485	E>*		No	ClinGen ESP TOPMed
rs11551743 CA315639148	485	E>K		No	ClinGen ESP TOPMed
rs1446497234 CA409228046	487	T>S		No	ClinGen TOPMed
rs1471920675 CA409228094	489	L>V		No	ClinGen gnomAD
CA409228167 rs1183877160	491	G>V		No	ClinGen gnomAD
rs769259496 CA9884527	495	V>L		No	ClinGen ExAC TOPMed gnomAD
CA409228300 rs1372363007	496	H>R		No	ClinGen gnomAD
rs556636968 CA9884528	497	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs140304055 CA9884529	499	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA315639172 rs939440557	499	E>V		No	ClinGen TOPMed
CA9884530 rs765965052	503	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA315639174 rs1055727696	504	L>H		No	ClinGen TOPMed
rs1362436145 CA409228587	506	G>D		No	ClinGen TOPMed
rs1001133934 CA315639186	507	V>I		No	ClinGen TOPMed gnomAD
COSM1027342 CA409228750 rs1600509898	513	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1350449154 CA409228776	515	P>S		No	ClinGen TOPMed
CA9884536 rs764219475	516	L>F		No	ClinGen ExAC TOPMed gnomAD
rs764219475 CA409228786	516	L>V		No	ClinGen ExAC TOPMed gnomAD
CA9884539 rs778998408	521	R>C		No	ClinGen ExAC gnomAD
rs1186407407 CA409228858	521	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA315639201 rs747472122	526	A>V		No	ClinGen Ensembl
CA409228932 rs1171990644	528	P>S		No	ClinGen gnomAD
CA9884543 rs535909417	532	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409229037 rs1295835228	537	R>C		No	ClinGen gnomAD
rs769748383 CA9884544	537	R>H		No	ClinGen ExAC gnomAD
CA409229043 rs769748383	537	R>P		No	ClinGen ExAC gnomAD
CA315640638 rs917305886	539	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs758646700 CA9884558	540	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	545	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780918580 CA9884559	546	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1490814196 CA409229878	547	S>T		No	ClinGen gnomAD
CA409229998 rs1471328833	558	E>D		No	ClinGen gnomAD
CA9884560 rs752505018	558	E>K		No	ClinGen ExAC gnomAD
CA409230066 rs1364044742	564	M>V		No	ClinGen gnomAD
rs149784844 CA315640655 COSM107229	565	V>F	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs755982312 CA9884561	566	S>F		No	ClinGen ExAC TOPMed gnomAD
CA9884579 rs755894220	570	R>K		No	ClinGen ExAC gnomAD
rs755894220 CA9884578	570	R>T		No	ClinGen ExAC gnomAD
CA9884580 rs753688640	572	L>V		No	ClinGen ExAC gnomAD
CA409230299 rs1310856748	576	P>A		No	ClinGen gnomAD
rs577092226 CA9884582	576	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409230301 rs1310856748	576	P>S		No	ClinGen gnomAD
rs1296733938 CA409230312	577	E>K		No	ClinGen gnomAD
rs758046742 CA9884584	579	L>Q		No	ClinGen ExAC gnomAD
rs768867806 CA409230377	582	I>L		No	ClinGen ExAC gnomAD
rs768867806 CA9884587	582	I>V		No	ClinGen ExAC gnomAD
rs777081786 CA9884588	583	V>M		No	ClinGen ExAC gnomAD
CA9884589 rs748551268	589	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1184556937 CA409230492	589	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1600511223 CA409230517	590	E>D		No	ClinGen Ensembl
rs75057275 CA315640794	590	E>G		No	ClinGen Ensembl
CA409230526 rs1179078263	591	P>H		No	ClinGen TOPMed
CA409230528 rs1179078263	591	P>R		No	ClinGen TOPMed
rs1427246393 CA409230540	592	P>A		No	ClinGen gnomAD
rs916561608 CA315640797	592	P>R		No	ClinGen TOPMed
rs1355121511 CA409230580	594	P>A		No	ClinGen gnomAD
CA409230591 rs1465623315	594	P>R		No	ClinGen gnomAD
CA409230577 rs1355121511	594	P>T		No	ClinGen gnomAD
rs374415027 CA9884592	595	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA315640817 rs956081126	597	T>I		No	ClinGen TOPMed
rs1600511301 CA409230627	597	T>P		No	ClinGen Ensembl
rs144987485 CA9884595	598	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884596 rs115793726	598	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA315640836 rs144987485	598	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884598 rs757074440	599	M>T		No	ClinGen ExAC TOPMed gnomAD
CA9884597 rs753691736	599	M>V		No	ClinGen ExAC gnomAD
CA409230688 rs1227062212	601	Q>E		No	ClinGen TOPMed
CA9884599 rs765214477	602	S>N		No	ClinGen ExAC TOPMed gnomAD
CA9884600 rs750442407	603	R>C		No	ClinGen ExAC TOPMed gnomAD
CA409230714 rs750442407	603	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9884601 rs757958805	603	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA409230720 rs757958805	603	R>L		No	ClinGen ExAC gnomAD
rs779747083 CA9884602	604	F>I		No	ClinGen ExAC gnomAD
TCGA novel	604	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746616095 CA9884603	606	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs754678543 CA9884604	606	R>H		No	ClinGen ExAC gnomAD
rs770127005 CA9884607	609	L>W		No	ClinGen ExAC gnomAD
rs1432631075 CA409230800	610	I>L		No	ClinGen gnomAD
rs773699856 CA9884608	612	P>A		No	ClinGen ExAC gnomAD
rs773699856 CA315640925	612	P>T		No	ClinGen ExAC gnomAD
rs1320144161 CA409230859	614	F>S		No	ClinGen gnomAD
rs770966887 CA9884610	615	E>G		No	ClinGen ExAC gnomAD
rs372047866 CA9884613	619	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA409230929 rs1284631393	619	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs372047866 CA9884612	619	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs775640126 CA9884614	620	S>C		No	ClinGen ExAC gnomAD
CA315640933 rs866342181	623	Q>K		No	ClinGen Ensembl
CA409230974 rs1423875716	623	Q>R		No	ClinGen TOPMed
CA409231009 rs1243098750	625	I>M		No	ClinGen gnomAD
CA409231001 rs1218427480	625	I>V		No	ClinGen TOPMed gnomAD
rs758437481 CA9884618	626	C>S		No	ClinGen ExAC gnomAD
CA9884621 rs556398791	627	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA9884619 rs765935366	627	K>Q		No	ClinGen ExAC gnomAD
TCGA novel	631	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409231149 rs1366112449	632	H>R		No	ClinGen TOPMed
CA409231147 rs1412719766	632	H>Y		No	ClinGen TOPMed gnomAD
CA409231154 TCGA novel rs1600511729	633	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs201577176 CA9884640	636	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766986785 CA9884641	638	N>D		No	ClinGen ExAC gnomAD
rs752363393 CA9884642	638	N>S		No	ClinGen ExAC gnomAD
CA315641031 rs1049430585	639	T>M		No	ClinGen TOPMed
CA9884643 rs755799574	640	A>P		No	ClinGen ExAC gnomAD
CA9884645 rs182701917	641	V>G		No	ClinGen ExAC gnomAD
CA9884646 rs757696667	642	L>V		No	ClinGen ExAC gnomAD
CA409231223 rs1317659057	644	L>V		No	ClinGen gnomAD
rs199613696 CA409231248	647	D>E		No	ClinGen ExAC TOPMed gnomAD
rs778597602 CA9884648	647	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1374270862 CA409231252	648	P>S		No	ClinGen gnomAD
CA409231259 rs1205417568	649	G>D		No	ClinGen gnomAD
CA409231270 rs1442507962	651	A>T		No	ClinGen gnomAD
CA9884652 rs769011759	654	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA409231301 rs1448782034	655	P>L		No	ClinGen gnomAD
rs150805893 CA409231307	656	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884656 rs150805893	656	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs200149076 CA9884659	657	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200149076 CA9884660	657	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1304912586 CA409231314	658	E>Q		No	ClinGen TOPMed
rs1403402712 CA409231321	659	R>G		No	ClinGen TOPMed gnomAD
CA409231323 rs1394436152	659	R>Q		No	ClinGen TOPMed
CA409231322 rs1403402712	659	R>W		No	ClinGen TOPMed gnomAD
CA409231333 rs1600511907	661	Q>*		No	ClinGen Ensembl
rs1600511917 CA409231335	661	Q>R		No	ClinGen Ensembl
rs1462746277 CA409231342	662	E>A		No	ClinGen TOPMed
rs1462746277 CA409231343	662	E>G		No	ClinGen TOPMed
CA9884661 rs763744042	664	S>I		No	ClinGen ExAC gnomAD
CA409231373 rs1600511958	667	Y>H		No	ClinGen Ensembl
rs927357002 CA315641117	667	Y>S		No	ClinGen Ensembl
rs757592432 CA9884663	668	R>L		No	ClinGen ExAC TOPMed gnomAD
rs757592432 CA9884664	668	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs753543857 CA9884662	668	R>W		No	ClinGen ExAC TOPMed gnomAD
rs369978315 CA9884665	671	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs531918762 CA9884666	672	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9884667 COSM1162695 rs373861155	672	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs149514465 CA9884668	673	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884669 rs149514465	673	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9884671 rs748431263	677	G>A		No	ClinGen ExAC gnomAD
rs781554398 CA9884670	677	G>C		No	ClinGen ExAC gnomAD
CA9884672 rs748431263	677	G>V		No	ClinGen ExAC gnomAD
CA409231439 rs1264513286	678	S>F		No	ClinGen gnomAD
TCGA novel	678	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409231447 rs1475721769	680	S>P		No	ClinGen gnomAD
CA409231457 rs1171459354	681	S>L		No	ClinGen gnomAD
rs760175614 CA9884677	684	S>L		No	ClinGen ExAC TOPMed gnomAD
CA9884679 rs568412072	685	E>D		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	685	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9884678 rs763640084	685	E>V		No	ClinGen ExAC gnomAD
CA409231497 rs1471968537	687	K>R		No	ClinGen TOPMed gnomAD
CA9884682 rs750766782	689	R>Q		No	ClinGen ExAC gnomAD
rs374981227 CA9884681	689	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA409231527 rs1306452674	690	D>N		No	ClinGen TOPMed
rs758872414 CA9884683	691	S>L		No	ClinGen ExAC gnomAD
CA9884685 rs140397899	693	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs140397899 CA315641222	693	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs368720894 CA9884686	693	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs368720894 CA409231573	693	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1203122918 CA409231580	694	E>D		No	ClinGen gnomAD
CA409231574 rs1469444090	694	E>K		No	ClinGen TOPMed
rs1469444090 CA409231575	694	E>Q		No	ClinGen TOPMed
CA409231592 rs1263643788	695	Q>R		No	ClinGen gnomAD
rs1198687796 CA409231604	697	P>L		No	ClinGen gnomAD
rs748341312 CA9884688	699	R>C		No	ClinGen ExAC TOPMed gnomAD
rs756316870 CA9884690	699	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9884689 rs756316870	699	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9884693 rs775264425	700	E>G		No	ClinGen ExAC gnomAD
rs547744655 CA9884692	700	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1387670854 CA409231693	701	P>L		No	ClinGen gnomAD
CA409231703 rs1401796494	702	H>R		No	ClinGen TOPMed gnomAD
rs367581698 CA315641285	703	P>L		No	ClinGen Ensembl
rs1240672847 CA409231714	703	P>S		No	ClinGen TOPMed
CA409231741 rs1343660570	704	T>I		No	ClinGen gnomAD

No associated diseases with Q9H4Z3

2 regional properties for Q9H4Z3

Type	Name	Position	InterPro Accession
domain	WW domain	43 - 77	IPR001202
domain	PCIF1, WW domain	446 - 621	IPR022035

Functions

		Description
EC Number	2.1.1.62	Methyltransferases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
intercellular bridge	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am.
RNA polymerase II C-terminal domain binding	Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.
RNA polymerase II C-terminal domain phosphoserine binding	Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.
S-adenosyl-L-methionine binding	Binding to S-adenosyl-L-methionine.

3 GO annotations of biological process

Name	Definition
mRNA methylation	The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MANENHGSPR	EEASLLSHSP	GTSNQSQPCS	PKPIRLVQDL	PEELVHAGWE	KCWSRRENRP
70	80	90	100	110	120
YYFNRFTNQS	LWEMPVLGQH	DVISDPLGLN	ATPLPQDSSL	VETPPAENKP	RKRQLSEEQP
130	140	150	160	170	180
SGNGVKKPKI	EIPVTPTGQS	VPSSPSIPGT	PTLKMWGTSP	EDKQQAALLR	PTEVYWDLDI
190	200	210	220	230	240
QTNAVIKHRG	PSEVLPPHPE	VELLRSQLIL	KLRQHYRELC	QQREGIEPPR	ESFNRWMLER
250	260	270	280	290	300
KVVDKGSDPL	LPSNCEPVVS	PSMFREIMND	IPIRLSRIKF	REEAKRLLFK	YAEAARRLIE
310	320	330	340	350	360
SRSASPDSRK	VVKWNVEDTF	SWLRKDHSAS	KEDYMDRLEH	LRRQCGPHVS	AAAKDSVEGI
370	380	390	400	410	420
CSKIYHISLE	YVKRIREKHL	AILKENNISE	EVEAPEVEPR	LVYCYPVRLA	VSAPPMPSVE
430	440	450	460	470	480
MHMENNVVCI	RYKGEMVKVS	RNYFSKLWLL	YRYSCIDDSA	FERFLPRVWC	LLRRYQMMFG
490	500	510	520	530	540
VGLYEGTGLQ	GSLPVHVFEA	LHRLFGVSFE	CFASPLNCYF	RQYCSAFPDT	DGYFGSRGPC
550	560	570	580	590	600
LDFAPLSGSF	EANPPFCEEL	MDAMVSHFER	LLESSPEPLS	FIVFIPEWRE	PPTPALTRME
610	620	630	640	650	660
QSRFKRHQLI	LPAFEHEYRS	GSQHICKKEE	MHYKAVHNTA	VLFLQNDPGF	AKWAPTPERL
670	680	690	700
QELSAAYRQS	GRSHSSGSSS	SSSSEAKDRD	SGREQGPSRE	PHPT