AiPD: Autoinhibited Protein Database

Q9H4A9

Gene name	DPEP2 (UNQ284/PRO323)
Protein name	Dipeptidase 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64174
EC number	3.4.13.19: Dipeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-89 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

19-89 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9H4A9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H4A9-F1	Predicted				AlphaFoldDB

459 variants for Q9H4A9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA283210398 rs543813120	3	P>L		No	ClinGen 1000Genomes gnomAD
CA396416397 rs1449916065	4	S>F		No	ClinGen gnomAD
rs991058819 CA283210397	5	G>D		No	ClinGen TOPMed gnomAD
CA283210394 rs867172890	7	E>*		No	ClinGen Ensembl
rs867172890 CA396416370	7	E>K		No	ClinGen Ensembl
TCGA novel	7	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753922139 CA8123351	8	G>S		No	ClinGen ExAC gnomAD
CA8123350 rs374420900	9	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396416326 rs1220243915	10	G>C		No	ClinGen gnomAD
CA396416321 rs1340956528	10	G>D		No	ClinGen TOPMed gnomAD
CA396416318 rs1340956528	10	G>V		No	ClinGen TOPMed gnomAD
TCGA novel	11	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200428783 CA283210350	13	G>A		No	ClinGen 1000Genomes TOPMed gnomAD
CA283210354 rs905978611	13	G>S		No	ClinGen Ensembl
CA8123349 rs761014774	18	L>P		No	ClinGen ExAC TOPMed gnomAD
CA283210346 rs761014774	18	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1462370879 CA396416214	19	S>G		No	ClinGen gnomAD
CA283210326 rs1005054568	21	L>P		No	ClinGen TOPMed gnomAD
rs767923462 CA283210321	22	L>F		No	ClinGen gnomAD
rs767923462 CA396416183	22	L>I		No	ClinGen gnomAD
rs768012798 CA8123346	27	L>P		No	ClinGen ExAC gnomAD
CA396416108 rs1200502217	28	Q>*		No	ClinGen gnomAD
CA396416088 rs1217066378	29	P>H		No	ClinGen gnomAD
CA396416093 rs1300362774	29	P>S		No	ClinGen gnomAD
rs1326258554 CA396416074	30	V>A		No	ClinGen gnomAD
rs762204698 CA8123343	30	V>L		No	ClinGen ExAC
CA8123341 rs539349506	32	C>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA283210261 rs1030094590	32	C>S		No	ClinGen TOPMed gnomAD
CA8123340 rs762170244	33	A>T		No	ClinGen ExAC TOPMed gnomAD
CA396416020 rs1374093541	34	Y>N		No	ClinGen gnomAD
rs1467680609 CA396415990	35	T>I		No	ClinGen gnomAD
rs149049423 CA8123339	35	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1412930113 CA396415972	37	P>S		No	ClinGen gnomAD
CA8123337 rs769325455	38	G>A		No	ClinGen ExAC gnomAD
rs780785366 CA396415953	39	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8123334 rs145012164	39	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs780785366 CA8123335	39	P>T		No	ClinGen ExAC TOPMed gnomAD
CA396415935 rs777610323	40	P>L		No	ClinGen ExAC gnomAD
CA8123332 rs777610323	40	P>R		No	ClinGen ExAC gnomAD
CA8123333 rs746747602	40	P>S		No	ClinGen ExAC TOPMed gnomAD
rs547189498	41	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA8123329 rs752645368	41	R>T		No	ClinGen ExAC TOPMed gnomAD
CA8123328 rs200981093	42	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA396415897 rs1239042849	43	L>F		No	ClinGen gnomAD
rs756211499 CA396415876	45	T>K		No	ClinGen ExAC TOPMed gnomAD
rs756211499 CA8123327	45	T>M		No	ClinGen ExAC TOPMed gnomAD
CA396415860 rs1393597087	47	G>R		No	ClinGen gnomAD
rs1457599759 CA396415840	48	A>V		No	ClinGen gnomAD
rs201209256 CA8123326	51	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA396415752 rs1361324012	54	M>T		No	ClinGen gnomAD
CA396415730 rs976384250	55	P>L		No	ClinGen gnomAD
rs976384250 CA283210182	55	P>R		No	ClinGen gnomAD
rs867883223 CA283210183	55	P>S		No	ClinGen TOPMed
rs1349607624 CA396415722	56	G>D		No	ClinGen TOPMed
rs1378499861 CA396415729	56	G>S		No	ClinGen gnomAD
CA396415718 rs1419532600	57	T>A		No	ClinGen gnomAD
CA396415703 rs1255377803	58	Y>C		No	ClinGen gnomAD
CA8123323 rs762116484	59	A>S		No	ClinGen ExAC TOPMed gnomAD
rs762116484 CA283210171	59	A>T		No	ClinGen ExAC TOPMed gnomAD
CA396415679 rs1258014906	60	P>L		No	ClinGen gnomAD
rs774650281 CA8123322	64	L>F		No	ClinGen ExAC TOPMed gnomAD
rs764491847 CA8123321	64	L>P		No	ClinGen ExAC gnomAD
CA396415631 rs1320665142	65	S>G		No	ClinGen gnomAD
CA283210131 rs1004055130	66	S>N		No	ClinGen gnomAD
rs1357710678 CA396415584	68	S>R		No	ClinGen gnomAD
CA396415569 rs1313888705	69	T>I		No	ClinGen gnomAD
rs776016094 CA8123318	70	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1368018878 CA396415523	73	Q>*		No	ClinGen gnomAD
rs776277985 CA8123315	74	E>G		No	ClinGen ExAC gnomAD
rs1598273005 CA396415498	75	Q>E		No	ClinGen Ensembl
CA396415490 rs1418244868	75	Q>R		No	ClinGen gnomAD
rs1487068051 CA396415469	77	R>P		No	ClinGen gnomAD
CA396415467 rs1487068051	77	R>Q		No	ClinGen gnomAD
CA396415471 rs1192684935	77	R>W		No	ClinGen gnomAD
rs770625516 CA8123314	79	L>P		No	ClinGen ExAC gnomAD
CA8123313 rs746669449	80	M>I		No	ClinGen ExAC gnomAD
CA8123311 rs202239509	81	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8123310 rs202239509	81	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777466466 CA8123312	81	R>W		No	ClinGen ExAC gnomAD
rs1243187512 CA396415412	82	D>N		No	ClinGen gnomAD
rs778866453 CA8123309	83	F>L		No	ClinGen ExAC gnomAD
CA396415376 rs1248948278	84	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	84	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149918129 CA396415366	85	L>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8123306 rs149918129	85	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396415351 rs1374340059	86	V>G		No	ClinGen gnomAD
rs370389022 CA8123303	86	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA396415341 rs763339034 CA396415340	87	D>E		No	ClinGen ExAC gnomAD
rs1390058968 CA396415343	87	D>G		No	ClinGen gnomAD
CA8123301 rs753151494	88	G>C		No	ClinGen ExAC TOPMed gnomAD
CA283210044 rs753151494	88	G>S		No	ClinGen ExAC TOPMed gnomAD
CA396415294 rs1254473418	89	H>R		No	ClinGen gnomAD
CA8123274 rs144507252	91	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA396415256 rs1308648060	93	P>L		No	ClinGen gnomAD
rs147847477 CA8123273	93	P>S		No	ClinGen ESP ExAC gnomAD
rs1378176788 CA396415249	94	L>P		No	ClinGen TOPMed
TCGA novel	95	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396415234 rs1444402712	96	L>P		No	ClinGen TOPMed gnomAD
CA8123270 rs768551952	97	R>K		No	ClinGen ExAC gnomAD
CA283209754 rs964424635	98	Q>*		No	ClinGen TOPMed
rs1329534074 CA396415212	98	Q>H		No	ClinGen gnomAD
rs749261378 CA8123269	99	V>A		No	ClinGen ExAC TOPMed gnomAD
rs749261378 CA396415202	99	V>G		No	ClinGen ExAC TOPMed gnomAD
CA396415164 rs1299689361	103	G>A		No	ClinGen TOPMed
CA396415156 rs1399856858	104	L>P		No	ClinGen gnomAD
CA283209751 rs895927796	105	Q>R		No	ClinGen gnomAD
CA8123268 rs76898487	106	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1434981628 CA396415144	106	D>N		No	ClinGen gnomAD
rs554053966 CA8123267	107	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA8123266 rs747054444	110	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8123265 rs777699818 COSM471967	110	R>H	kidney Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	111	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396415095 rs1213241643	111	N>S		No	ClinGen gnomAD
TCGA novel	113	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs574279521 CA8123262	115	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396415037 rs1353005421	117	T>S		No	ClinGen gnomAD
TCGA novel	121	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755283112 CA396414993	122	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755283112 CA8123261	122	L>I		No	ClinGen ExAC TOPMed gnomAD
CA396414985 rs1244024705	123	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754369932 CA8123260	124	D>E		No	ClinGen ExAC TOPMed gnomAD
CA396414959 rs1314516365	126	L>F		No	ClinGen TOPMed gnomAD
CA396414960 rs1314516365	126	L>V		No	ClinGen TOPMed gnomAD
CA8123258 rs755590475	127	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750019739 CA8123257	128	G>D		No	ClinGen ExAC gnomAD
rs547766230 CA283209697	129	A>D		No	ClinGen gnomAD
COSM3691115 CA8123255 rs761580112	129	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs547766230 CA396414930	129	A>V		No	ClinGen gnomAD
CA396414927 rs1267959518	130	Q>*		No	ClinGen TOPMed
rs751262522 CA8123236	132	W>C		No	ClinGen ExAC gnomAD
rs971304004 CA283209461	132	W>R		No	ClinGen TOPMed
rs1216206590 CA396414844	135	Y>C		No	ClinGen TOPMed
rs1314048809 CA396414822	138	C>G		No	ClinGen TOPMed gnomAD
rs763783491 CA8123235	139	Q>R		No	ClinGen ExAC gnomAD
CA8123234 rs762684170	141	Q>R		No	ClinGen ExAC gnomAD
rs142359415 CA8123233	142	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200552217 COSM1629957 CA8123232	143	R>Q	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1012680301 CA283209437	143	R>W		No	ClinGen TOPMed
CA396414757 rs1567447944	144	D>G		No	ClinGen Ensembl
rs1273945484 CA396414762	144	D>N		No	ClinGen gnomAD
CA396414749 rs1209716632	145	A>P		No	ClinGen TOPMed
CA396414744 rs1372598527	145	A>V		No	ClinGen gnomAD
TCGA novel	146	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8123230 COSM558609 rs368802189	146	L>P	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA396414736 rs1462454600	147	R>C		No	ClinGen gnomAD
rs768027580 CA8123228	147	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8123229 rs768027580	147	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8123226 rs375989977	151	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1420488251 CA396414690	152	Q>*		No	ClinGen gnomAD
rs531799009 CA8123224	153	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA283209380 rs148736668	153	I>T		No	ClinGen ESP
TCGA novel	154	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396414655 rs1160599537	155	L>F		No	ClinGen gnomAD
CA396414638 rs1255009731	156	I>T		No	ClinGen TOPMed gnomAD
COSM972661 rs201555693 CA8123223	157	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs201555693 CA283209368	157	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs564605320 CA8123222 COSM460488	157	R>H	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs564605320 CA396414628	157	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA8123221 rs781484778	158	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8123219 rs368160537	158	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8123220 rs368160537	158	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs919579657 CA283209348	159	M>I		No	ClinGen Ensembl
CA396414596 rs1598269350	160	C>Y		No	ClinGen Ensembl
CA8123217 rs144339907	163	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777419220 CA8123218	163	Y>S		No	ClinGen ExAC gnomAD
CA396414543 rs1567447690	164	S>Y		No	ClinGen Ensembl
rs752268573 CA8123216 COSM1709311	167	E>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1303532869 CA396414486	168	L>P		No	ClinGen TOPMed gnomAD
CA396414462 rs1376818232	170	T>N		No	ClinGen TOPMed gnomAD
rs753813676 CA8123213 COSM1379054	171	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs555934050 CA8123188	176	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA396414332 rs1598268634	176	N>S		No	ClinGen Ensembl
CA8123187 rs775795150	177	D>H		No	ClinGen ExAC gnomAD
CA8123186 rs775795150	177	D>N		No	ClinGen ExAC gnomAD
rs1355579856 CA396414303	178	T>S		No	ClinGen TOPMed gnomAD
CA396414252 rs1275643203	182	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8123183 rs139782026	185	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs139782026 CA8123185	185	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs139782026 CA8123184	185	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8123181 rs201302210	186	G>C		No	ClinGen 1000Genomes ExAC gnomAD
CA8123180 rs201302210	186	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA396414190 rs1484590959	187	V>I		No	ClinGen gnomAD
rs146393703 CA8123177	188	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA8123178 rs146393703	188	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA396414161 rs1598268417	189	G>V		No	ClinGen Ensembl
TCGA novel	192	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396414120 rs1407291141	193	L>P		No	ClinGen TOPMed
rs748950745 CA283209142	194	D>H		No	ClinGen ExAC gnomAD
rs748950745 CA8123175	194	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8123173 rs141563048	197	L>F		No	ClinGen ESP ExAC gnomAD
CA8123172 rs750368497	197	L>P		No	ClinGen ExAC gnomAD
rs374497696 CA8123171	199	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs374497696 CA396414064	199	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1047696472 CA283209132	201	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel CA658682938 rs255051	201	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA 1000Genomes ESP ExAC gnomAD
CA283209109 rs255051 VAR_060230	201	R>P		No	ClinGen UniProt 1000Genomes ESP ExAC dbSNP gnomAD
CA396414040 rs1331723561	202	T>I		No	ClinGen TOPMed
rs1278640029 CA396414017	204	Y>*		No	ClinGen TOPMed
rs1162779343 CA396414025	204	Y>H		No	ClinGen gnomAD
CA8123167 rs370066264	205	M>I		No	ClinGen ESP ExAC gnomAD
rs765330926 CA8123168	205	M>L		No	ClinGen ExAC gnomAD
CA396414008 rs1476286665	205	M>T		No	ClinGen gnomAD
CA283209093 rs374923512	209	R>C		No	ClinGen ESP gnomAD
CA8123166 rs373145757	209	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8123165 rs202183776	210	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1186601015 CA396413971	210	Y>H		No	ClinGen gnomAD
CA396413960 rs1273079570	211	L>V		No	ClinGen gnomAD
CA8123163 rs150079633 COSM1379053	212	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA283209083 rs150079633	212	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA396413941 rs1274219623	213	L>P		No	ClinGen gnomAD
rs1056361250 CA396413912	216	T>I		No	ClinGen gnomAD
rs1056361250 CA283209073	216	T>S		No	ClinGen gnomAD
rs748681048 CA8123160	217	C>*		No	ClinGen ExAC gnomAD
TCGA novel	217	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8123161 rs772509435	217	C>S		No	ClinGen ExAC gnomAD
TCGA novel	219	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8123157 rs748927361	220	P>R		No	ClinGen ExAC gnomAD
CA396413880 rs768166328	220	P>S		No	ClinGen ExAC gnomAD
CA8123158 rs768166328	220	P>T		No	ClinGen ExAC gnomAD
CA283209037 rs772615767 COSM3957743	221	W>*	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs769506790 CA396413452 COSM3957743	221	W>*	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs769506790 CA8123131	221	W>C		No	ClinGen ExAC gnomAD
rs186958025 CA8123130	223	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8123127 rs764677038	226	A>T		No	ClinGen ExAC TOPMed
rs746948522 CA283208493	227	K>N		No	ClinGen ExAC TOPMed gnomAD
rs777696064 CA396413388	228	G>A		No	ClinGen ExAC gnomAD
rs777696064 CA8123124	228	G>V		No	ClinGen ExAC gnomAD
rs182589890 CA8123122	229	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396413372 rs780276903	230	H>L		No	ClinGen ExAC TOPMed gnomAD
CA396413374 rs780276903	230	H>P		No	ClinGen ExAC TOPMed gnomAD
CA8123121 rs780276903	230	H>R		No	ClinGen ExAC TOPMed gnomAD
CA8123116 rs552543500	237	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396413304 rs1434765900	237	S>R		No	ClinGen TOPMed gnomAD
CA396413300 rs1383677983	238	G>R		No	ClinGen TOPMed gnomAD
rs942775952 CA283208460	238	G>V		No	ClinGen Ensembl
rs752021379 CA8123115	241	D>E		No	ClinGen ExAC gnomAD
rs1272477138 CA396413284	241	D>Y		No	ClinGen gnomAD
CA396413268 rs1183367340	243	G>D		No	ClinGen gnomAD
CA396413237 rs963010731	246	V>L		No	ClinGen TOPMed gnomAD
CA283208349 rs963010731	246	V>M		No	ClinGen TOPMed gnomAD
rs765970809 CA8123090	250	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1326540802 CA396413209	250	M>T		No	ClinGen gnomAD
rs760294074 CA396413196	252	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs758977397 CA8123089	252	R>H		No	ClinGen ExAC TOPMed gnomAD
rs758977397 CA396413194	252	R>L		No	ClinGen ExAC TOPMed gnomAD
rs760294074 CA283208348	252	R>S		No	ClinGen gnomAD
CA396413183 rs1406378345	254	G>V		No	ClinGen TOPMed gnomAD
CA8123088 rs776157509	255	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1598264380 CA396413179	255	M>T		No	ClinGen Ensembl
CA8123087 rs530061182	256	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1452763390 CA396413172	256	M>V		No	ClinGen TOPMed
rs976551789 CA283208331	257	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1248746992 CA396413141	260	S>F		No	ClinGen gnomAD
rs1248746992 CA396413143	260	S>Y		No	ClinGen gnomAD
CA396413137 rs1420998100	261	H>R		No	ClinGen TOPMed
rs1034806253 CA283208309	261	H>Y		No	ClinGen gnomAD
rs771969590 CA8123084	262	V>I		No	ClinGen ExAC gnomAD
CA396413117 rs1387893777	264	D>G		No	ClinGen TOPMed
TCGA novel	265	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1170229002 CA396413095	268	R>Q		No	ClinGen TOPMed gnomAD
rs748116361 CA8123083	268	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8123081 rs201396720	269	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8123082 rs550446323	269	R>W	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs986242989 CA283208231	273	V>L		No	ClinGen TOPMed
CA396413057 rs1221645138	275	Q>*		No	ClinGen TOPMed
CA8123078 rs371496343	276	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	277	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8123077 rs147996284	277	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1354369674 CA396413038	278	V>E		No	ClinGen gnomAD
CA8123076 rs778135734	280	F>Y		No	ClinGen ExAC gnomAD
CA396413010 rs1390789344	282	H>L		No	ClinGen gnomAD
rs1173104337 CA396413008	282	H>Q		No	ClinGen gnomAD
CA396413003 rs1452721094	283	S>*		No	ClinGen TOPMed gnomAD
CA396413002 rs1452721094	283	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs868542914 CA283208201	284	A>S		No	ClinGen Ensembl
CA8123072 rs753450669	286	R>G		No	ClinGen ExAC gnomAD
rs527641282 CA8123070	286	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs753450669 CA8123071	286	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1206106020 CA396412986	287	G>C		No	ClinGen gnomAD
CA396412988 rs1206106020	287	G>S		No	ClinGen gnomAD
rs760423409 CA8123069	289	C>*		No	ClinGen ExAC gnomAD
rs1038836885 CA283208164	291	S>R		No	ClinGen Ensembl
CA396412954 rs774095703	292	A>P		No	ClinGen gnomAD
CA283208163 rs774095703	292	A>T		No	ClinGen gnomAD
CA396412949 rs376501465	293	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs200429288 CA8123067	293	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376501465 CA8123068	293	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8123065 rs373693556	298	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA396412908 rs1373003668	299	I>N		No	ClinGen gnomAD
rs200694435 CA8123062	301	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372203515 CA8123045	304	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396412857 rs1429266635	305	K>N		No	ClinGen TOPMed
CA8123042 rs145887676	307	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs145887676 CA8123041	307	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs372357723 CA283207569	308	G>S		No	ClinGen ESP TOPMed gnomAD
CA396412841 rs1475986745	308	G>V		No	ClinGen gnomAD
CA396412834 rs1598261570	309	V>A		No	ClinGen Ensembl
rs140744195 CA8123039	309	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396412833 rs779298810	310	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8123037 rs779298810	310	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8123035 rs749830324	314	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	314	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396412798 rs1371930305	315	S>Y		No	ClinGen Ensembl
CA8123034 rs780357249	316	M>V		No	ClinGen ExAC gnomAD
CA8123032 rs750023132	318	V>G		No	ClinGen ExAC gnomAD
CA8123033 rs201800946	318	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8123031 rs780818900	319	I>T		No	ClinGen ExAC gnomAD
rs146119054 CA283207508	320	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs146119054 CA8123030	320	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA396412759 rs763983825	321	C>*		No	ClinGen ExAC gnomAD
CA8123027 rs372211741	322	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs368738582 CA283207475	322	N>I		No	ClinGen ESP TOPMed
rs182720433 CA8123026	322	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA396412755 rs368738582	322	N>T		No	ClinGen ESP TOPMed
CA396412742 rs1368679118	324	S>*		No	ClinGen gnomAD
CA283207469 rs374262446	326	N>S		No	ClinGen ESP TOPMed gnomAD
rs1169354300 CA396412722	327	V>G		No	ClinGen gnomAD
CA396412703 rs1421048804	331	A>T		No	ClinGen gnomAD
CA396412698 rs1174270824	331	A>V		No	ClinGen TOPMed
rs1235351787 CA396412599	334	F>V		No	ClinGen gnomAD
rs540505554 COSM1379051 CA8122995	335	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA8122994 rs777214198	336	H>N		No	ClinGen ExAC gnomAD
rs573249608 CA8122993	336	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396412557 rs1308303814	338	K>R		No	ClinGen gnomAD
rs1033727371 CA283206897	339	A>T		No	ClinGen TOPMed gnomAD
CA283206892 rs866617431	339	A>V		No	ClinGen Ensembl
CA283206882 rs375949900	340	V>F		No	ClinGen ExAC gnomAD
CA8122992 rs375949900	340	V>I		No	ClinGen ExAC gnomAD
CA396412512 rs1433126524	343	S>F		No	ClinGen TOPMed
CA396412505 rs1171296107	344	K>R		No	ClinGen gnomAD
CA396412493 rs1378517016	345	F>S		No	ClinGen gnomAD
CA8122991 rs777330949	346	I>M		No	ClinGen ExAC gnomAD
rs1003638678 CA283206872	346	I>T		No	ClinGen Ensembl
rs142237629 CA8122990	347	G>R		No	ClinGen ESP ExAC gnomAD
rs1438626580 CA396412460	349	G>C		No	ClinGen TOPMed
rs374612240 CA8122989	349	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396412463 rs1438626580	349	G>S		No	ClinGen TOPMed
rs754728021 CA8122988	353	D>H		No	ClinGen ExAC gnomAD
rs754728021 CA8122987	353	D>N		No	ClinGen ExAC gnomAD
CA8122986 rs753778067	354	G>E		No	ClinGen ExAC gnomAD
CA396412403 rs1555504690	355	A>S		No	ClinGen Ensembl
CA396412401 rs1228965230	355	A>V		No	ClinGen TOPMed
rs1207698660	356	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396412393 rs1345641691	356	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA396412389 rs1260145863	356	G>V		No	ClinGen gnomAD
CA283205879 rs1006367281	358	F>L		No	ClinGen Ensembl
CA8122964 rs145720875	360	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA283205875 rs1034005827	361	G>E		No	ClinGen Ensembl
rs1567440709 CA396412284	361	G>R		No	ClinGen Ensembl
CA8122962 rs199952465	364	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201163956 CA8122960	365	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1411862888 CA396412235	368	Y>*		No	ClinGen TOPMed gnomAD
CA396412232 rs1365482368	369	P>A		No	ClinGen TOPMed
rs752877869 CA8122959	369	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1372611838 CA396412226	370	V>D		No	ClinGen gnomAD
CA283205827 rs956903082	372	I>R		No	ClinGen TOPMed gnomAD
rs759825248 CA8122957	373	E>Q		No	ClinGen ExAC gnomAD
rs1046025109 CA283205816	377	S>G		No	ClinGen TOPMed gnomAD
CA396412176 rs1567440531	378	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8122956 rs754291865	378	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8122955 rs766824465	379	G>R		No	ClinGen ExAC gnomAD
CA8122954 rs761104550	381	S>G		No	ClinGen ExAC gnomAD
CA8122952 rs771486495	381	S>R		No	ClinGen ExAC gnomAD
rs573954866 CA8122950	383	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8122951 rs375315698	383	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1003206502 CA396412134 CA283205775	384	E>D		No	ClinGen TOPMed
rs112383450 CA283205782	384	E>G		No	ClinGen Ensembl
CA8122949 rs199768673	386	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396412117 rs1440605472	387	G>D		No	ClinGen gnomAD
rs779846889 CA8122947	388	V>I		No	ClinGen ExAC gnomAD
rs1325735325 CA396412106	389	L>H		No	ClinGen TOPMed gnomAD
CA8122946 rs769539400	390	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA283205766 rs769539400	390	R>G		No	ClinGen ExAC TOPMed gnomAD
rs181288789 CA8122945	390	R>H		No	ClinGen 1000Genomes ExAC TOPMed
CA396412096 rs1395792587	391	G>E		No	ClinGen gnomAD
rs569731919 CA283205760	391	G>R		No	ClinGen 1000Genomes TOPMed
CA283205758 rs936751524	392	N>I		No	ClinGen Ensembl
CA396412092 rs936751524	392	N>T		No	ClinGen Ensembl
CA8122942 rs144454541	395	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs757133675 CA8122943	395	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1598253195 CA396412072	396	V>G		No	ClinGen Ensembl
rs766877867 CA8122939	399	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs766877867 CA8122938	399	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA8122937 rs756432860	400	V>A		No	ClinGen ExAC gnomAD
rs1598253123 CA396412047	400	V>L		No	ClinGen Ensembl
rs768127528 CA8122935	402	K>N		No	ClinGen ExAC TOPMed gnomAD
rs546959816 CA8122916	403	V>A		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	403	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396412003 rs1310943604	405	E>K		No	ClinGen TOPMed gnomAD
rs976719141 CA283205589	406	E>K		No	ClinGen TOPMed gnomAD
rs763600957 CA8122915	407	N>S		No	ClinGen ExAC gnomAD
rs146351596 CA8122914	410	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA396411952 rs1286628963	411	S>I		No	ClinGen gnomAD
rs1411931310 CA396411947	412	P>H		No	ClinGen gnomAD
CA8122913 rs774970419	412	P>S		No	ClinGen ExAC TOPMed
rs528870660 CA8122912	413	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1351110750 CA396411941	413	L>S		No	ClinGen gnomAD
rs1445979325 CA396411938	414	E>K		No	ClinGen gnomAD
CA396411916 rs759082940	416	K>N		No	ClinGen ExAC TOPMed gnomAD
CA8122910 rs776534967	418	P>A		No	ClinGen ExAC gnomAD
rs964100978 CA283205525	418	P>L		No	ClinGen TOPMed
rs746971748 CA8122908	419	D>N		No	ClinGen ExAC gnomAD
CA8122907 rs773213621	420	E>D		No	ClinGen ExAC gnomAD
rs1160845280 CA396411895	420	E>K		No	ClinGen gnomAD
CA283205521 rs756901785	424	S>G		No	ClinGen Ensembl
rs1483970874 CA396411614	425	S>F		No	ClinGen gnomAD
rs183628292 CA8122906	425	S>P		No	ClinGen ExAC gnomAD
rs779993387 CA8122904	426	C>*		No	ClinGen ExAC gnomAD
rs756398108 CA8122903	427	H>D		No	ClinGen ExAC gnomAD
CA8122901 rs781644300	429	D>N		No	ClinGen ExAC TOPMed gnomAD
CA396411552 rs1598252011	430	L>I		No	ClinGen Ensembl
rs1381489505 CA396411531	431	S>L		No	ClinGen TOPMed gnomAD
CA396411540 rs1226646459	431	S>P		No	ClinGen gnomAD
CA283205483 rs1015495896	432	R>C		No	ClinGen gnomAD
rs200614898 CA8122900	432	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200614898 CA396411521	432	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8122899 rs752075576	433	L>P		No	ClinGen ExAC gnomAD
CA8122898 rs778313366	434	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8122897 rs758904218	434	R>H		No	ClinGen ExAC TOPMed gnomAD
CA283205468 rs528966964	437	Q>L		No	ClinGen Ensembl
rs757915998 CA8122895	438	S>T		No	ClinGen ExAC gnomAD
CA8122893 rs753390615	440	T>P		No	ClinGen ExAC gnomAD
rs766197649 CA8122892	442	G>D		No	ClinGen ExAC TOPMed gnomAD
rs866783628 CA283205448	444	E>K		No	ClinGen Ensembl
TCGA novel	444	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs566224645 CA283205445	447	E>K		No	ClinGen ExAC gnomAD
rs566224645 CA8122891	447	E>Q		No	ClinGen ExAC gnomAD
rs1265060030 CA396411279	449	P>A		No	ClinGen gnomAD
rs1287038826 CA396411250	450	I>M		No	ClinGen TOPMed gnomAD
CA396411255 rs1382895594	450	I>T		No	ClinGen TOPMed
CA8122890 rs772202768	451	H>N		No	ClinGen ExAC gnomAD
CA8122889 rs772202768	451	H>Y		No	ClinGen ExAC gnomAD
rs761810107 CA8122888	452	W>R		No	ClinGen ExAC gnomAD
rs1567439370 CA396411204	453	T>I		No	ClinGen Ensembl
CA396411191 rs1313552022	454	A>V		No	ClinGen gnomAD
rs775662244 CA8122886	455	K>N		No	ClinGen ExAC gnomAD
rs148784169 CA8122884	458	A>T		No	ClinGen ESP ExAC TOPMed
CA8122883 rs781214458	460	W>C		No	ClinGen ExAC
rs1435518589 CA396411133	460	W>R		No	ClinGen gnomAD
rs1291388640 CA396411102	463	S>*		No	ClinGen gnomAD
CA396411104 rs143876744	463	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA8122882 rs143876744	463	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs747442513 CA8122881	465	S>C		No	ClinGen ExAC gnomAD
rs747442513 CA396411085	465	S>F		No	ClinGen ExAC gnomAD
rs758957088 CA8122879	466	S>F		No	ClinGen ExAC TOPMed gnomAD
CA8122880 rs778084333	466	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1598251360 CA396411069	467	P>R		No	ClinGen Ensembl
CA8122876 rs1133090 VAR_033894	468	H>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8122877 rs1133090	468	H>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1023404475	468	H>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA8122878 rs1133090	468	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766003939 CA8122874	469	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8122875 rs531284451	469	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396410976 rs1598251230	478	T>S		No	ClinGen Ensembl
rs267604603 COSM36719 CA283205381	480	P>S	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA8122873 rs760397309	484	L>V		No	ClinGen ExAC gnomAD
CA283205377 rs866029507	485	W>*		No	ClinGen TOPMed
CA396410910 rs866029507	485	W>C		No	ClinGen TOPMed
TCGA novel	487	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q9H4A9

4 regional properties for Q9H4A9

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	66 - 87	IPR001611-1
repeat	Leucine-rich repeat	88 - 109	IPR001611-2
repeat	Leucine-rich repeat	110 - 131	IPR001611-3
repeat	Leucine-rich repeat	132 - 153	IPR001611-4

Functions

		Description
EC Number	3.4.13.19	Dipeptidases
Subcellular Localization	Membrane ; Lipid-anchor, GPI-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
anchored component of membrane	The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.

3 GO annotations of molecular function

Name	Definition
dipeptidase activity	Catalysis of the hydrolysis of a dipeptide.
metal ion binding	Binding to a metal ion.
metallodipeptidase activity	Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

3 GO annotations of biological process

Name	Definition
leukotriene D4 catabolic process	The chemical reactions and pathways resulting in the breakdown of leukotriene D4.
leukotriene metabolic process	The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MQPSGLEGPG	TFGRWPLLSL	LLLLLLLQPV	TCAYTTPGPP	RALTTLGAPR	AHTMPGTYAP
70	80	90	100	110	120
STTLSSPSTQ	GLQEQARALM	RDFPLVDGHN	DLPLVLRQVY	QKGLQDVNLR	NFSYGQTSLD
130	140	150	160	170	180
RLRDGLVGAQ	FWSAYVPCQT	QDRDALRLTL	EQIDLIRRMC	ASYSELELVT	SAKALNDTQK
190	200	210	220	230	240
LACLIGVEGG	HSLDNSLSIL	RTFYMLGVRY	LTLTHTCNTP	WAESSAKGVH	SFYNNISGLT
250	260	270	280	290	300
DFGEKVVAEM	NRLGMMVDLS	HVSDAVARRA	LEVSQAPVIF	SHSAARGVCN	SARNVPDDIL
310	320	330	340	350	360
QLLKKNGGVV	MVSLSMGVIQ	CNPSANVSTV	ADHFDHIKAV	IGSKFIGIGG	DYDGAGKFPQ
370	380	390	400	410	420
GLEDVSTYPV	LIEELLSRGW	SEEELQGVLR	GNLLRVFRQV	EKVQEENKWQ	SPLEDKFPDE
430	440	450	460	470	480
QLSSSCHSDL	SRLRQRQSLT	SGQELTEIPI	HWTAKLPAKW	SVSESSPHMA	PVLAVVATFP

VLILWL