Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9H489
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9H489-F1 | Predicted | AlphaFoldDB |
1 variants for Q9H489
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs3813922 VAR_020256 |
246 | P>H | No |
UniProt dbSNP |
No associated diseases with Q9H489
12 regional properties for Q9H489
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 94 - 135 | IPR000315 |
| domain | Zinc finger, RING-type | 16 - 61 | IPR001841 |
| domain | B30.2/SPRY domain | 292 - 486 | IPR001870 |
| domain | SPRY domain | 362 - 485 | IPR003877 |
| domain | Butyrophylin-like, SPRY domain | 308 - 325 | IPR003879-1 |
| domain | Butyrophylin-like, SPRY domain | 325 - 342 | IPR003879-2 |
| domain | Butyrophylin-like, SPRY domain | 347 - 371 | IPR003879-3 |
| domain | Butyrophylin-like, SPRY domain | 379 - 392 | IPR003879-4 |
| domain | Butyrophylin-like, SPRY domain | 422 - 446 | IPR003879-5 |
| domain | Butyrophylin-like, SPRY domain | 452 - 470 | IPR003879-6 |
| domain | SPRY-associated | 309 - 361 | IPR006574 |
| conserved_site | Zinc finger, RING-type, conserved site | 31 - 40 | IPR017907 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99457 | NAP1L3 | Nucleosome assembly protein 1-like 3 | Homo sapiens (Human) | PR |
| P55209 | NAP1L1 | Nucleosome assembly protein 1-like 1 | Homo sapiens (Human) | PR |
| Q01534 | TSPY1 | Testis-specific Y-encoded protein 1 | Homo sapiens (Human) | PR |
| P0CV99 | TSPY4 | Testis-specific Y-encoded protein 4 | Homo sapiens (Human) | PR |
| P0CV98 | TSPY3 | Testis-specific Y-encoded protein 3 | Homo sapiens (Human) | PR |
| P0CW00 | TSPY8 | Testis-specific Y-encoded protein 8 | Homo sapiens (Human) | PR |
| P0CW01 | TSPY10 | Testis-specific Y-encoded protein 10 | Homo sapiens (Human) | PR |
| A6NKD2 | TSPY2 | Testis-specific Y-encoded protein 2 | Homo sapiens (Human) | PR |
| Q8N831 | TSPYL6 | Testis-specific Y-encoded-like protein 6 | Homo sapiens (Human) | PR |
| Q9H2G4 | TSPYL2 | Testis-specific Y-encoded-like protein 2 | Homo sapiens (Human) | PR |
| P0DME0 | SETSIP | Protein SETSIP | Homo sapiens (Human) | SS |
| Q01105 | SET | Protein SET | Homo sapiens (Human) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADKRAGTPE | AAARPPPGLA | REGDARTVPA | ARAREAGGRG | SLHPAAGPGT | AFPSPGRGEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASTATTPSLE | NGRVRDEAPE | TCGAEGLGTR | AGASEKAEDA | NKEEGAIFKK | EPAEEVEKQQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGEEKQEVAA | EAQEGPRLLN | LGALIVDPLE | AIQWEAEAVS | AQADRAYLPL | ERRFGRMHRL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLARRSFIIQ | NIPGFWVTAF | LNHPQLSAMI | SPRDEDMLCY | LMNLEVRELR | HSRTGCKFKF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFWSNPYFQN | KVIVKEYECR | ASGRVVSIAT | RIRWHWGQEP | PALVHRNRDT | VRSFFSWFSQ |
| 310 | 320 | 330 | 340 | 350 | |
| HSLPEADRVA | QIIKDDLWPN | PLQYYLLGDR | PCRARGGLAR | WPTETPSRPY | GFQSG |