AiPD: Autoinhibited Protein Database

Q9H1J1

Gene name	UPF3A (RENT3A, UPF3)
Protein name	Regulator of nonsense transcripts 3A
Names	Nonsense mRNA reducing factor 3A, Up-frameshift suppressor 3 homolog A, hUpf3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:65110
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

293-378 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

293-378 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9H1J1

Entry ID	Method	Resolution	Chain	Position	Source
2L08	NMR	-	A	70-155	PDB
7QG6	X-ray	295 A	A/C/E/G	58-206	PDB
AF-Q9H1J1-F1	Predicted				AlphaFoldDB

470 variants for Q9H1J1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA388838440 rs1372751125	2	R>C		No	ClinGen TOPMed gnomAD
CA388838446 rs1382208617	2	R>H		No	ClinGen TOPMed
CA388838460 rs1366592633	3	S>W		No	ClinGen TOPMed
CA388838467 rs1023469713	4	E>G		No	ClinGen TOPMed gnomAD
rs759775018 CA7070020	4	E>K		No	ClinGen ExAC gnomAD
CA257264005 rs1023469713	4	E>V		No	ClinGen TOPMed gnomAD
CA388838481 TCGA novel rs1340545238	5	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed gnomAD NCI-TCGA
rs970416488 CA257264023	6	E>K		No	ClinGen TOPMed gnomAD
rs970416488 CA388838486	6	E>Q		No	ClinGen TOPMed gnomAD
rs1256344852 CA388838499	7	G>R		No	ClinGen gnomAD
rs1275294202 CA388838507	7	G>V		No	ClinGen Ensembl
rs775514726 CA7070022	8	A>S		No	ClinGen ExAC TOPMed gnomAD
rs775514726 CA388838510	8	A>T		No	ClinGen ExAC TOPMed gnomAD
rs910596329 CA257264025	8	A>V		No	ClinGen TOPMed gnomAD
rs1242292399 CA388838523	9	G>A		No	ClinGen TOPMed
CA7070023 rs545511962	9	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1474990197 CA388838530	10	G>D		No	ClinGen gnomAD
CA7070024 rs764647001	10	G>S		No	ClinGen ExAC gnomAD
CA388838539 rs1168307755	11	L>F		No	ClinGen gnomAD
rs754311829 CA7070025	12	R>W		No	ClinGen ExAC gnomAD
rs1014520051 CA257264059	13	A>E		No	ClinGen TOPMed
CA388838554 rs1324617329	13	A>T		No	ClinGen gnomAD
CA388838561 rs1014520051	13	A>V		No	ClinGen TOPMed
CA7070026 rs201273206	14	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7070028 rs751211531	15	V>L		No	ClinGen ExAC gnomAD
rs1362439331 CA388838582	16	A>T		No	ClinGen gnomAD
rs199669800 CA257264112	17	A>T		No	ClinGen Ensembl
rs920206864 CA257264120	17	A>V		No	ClinGen TOPMed gnomAD
rs1272621801 CA388838602	18	R>Q		No	ClinGen TOPMed gnomAD
CA7070029 rs754659664	18	R>W		No	ClinGen ExAC gnomAD
rs1594734520 CA388838608	19	G>R		No	ClinGen Ensembl
rs952908452 CA257264145	20	P>L		No	ClinGen TOPMed gnomAD
rs1170480409 CA388838616	20	P>T		No	ClinGen TOPMed
CA388838627 rs1446360989	21	S>G		No	ClinGen gnomAD
rs1191166968 CA388838631	21	S>N		No	ClinGen gnomAD
CA388838632 rs1191166968	21	S>T		No	ClinGen gnomAD
CA388838639 rs1419835066	22	G>R		No	ClinGen TOPMed gnomAD
rs1475326023 CA388838653	23	R>K		No	ClinGen gnomAD
CA388838654 rs1475326023	23	R>T		No	ClinGen gnomAD
rs985995959 CA257264153	24	E>K		No	ClinGen gnomAD
rs1454845718 CA388838684	25	K>N		No	ClinGen gnomAD
rs1288977974 CA388838686	26	L>M		No	ClinGen gnomAD
CA388838700 rs1386232236	27	S>L		No	ClinGen TOPMed gnomAD
rs1386232236 CA388838698	27	S>W		No	ClinGen TOPMed gnomAD
rs1296728016 CA388838707	28	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1415594770 CA388838712	29	L>I		No	ClinGen gnomAD
rs1483457459 CA388838720	29	L>R		No	ClinGen TOPMed
CA7070034 rs549694730	30	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA388838736 rs770710052 CA7070035	31	V>L		No	ClinGen ExAC gnomAD
rs770710052 CA388838735	31	V>M		No	ClinGen ExAC gnomAD
CA7070036 rs778656716	32	Q>H		No	ClinGen ExAC gnomAD
rs1220955385 CA388838763	33	F>S		No	ClinGen TOPMed
rs867684324 CA257264208	35	R>C		No	ClinGen gnomAD
CA257264219 rs866150021	35	R>L		No	ClinGen Ensembl
CA7070037 rs745703632	36	D>H		No	ClinGen ExAC gnomAD
CA257264231 rs866607014	37	S>*		No	ClinGen Ensembl
CA257264300 rs923922944	40	Q>*		No	ClinGen TOPMed gnomAD
rs923922944 CA257264280	40	Q>K		No	ClinGen TOPMed gnomAD
CA257264305 rs935362462	41	E>K		No	ClinGen TOPMed
rs369318678 CA7070040	42	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs768620649 CA7070041	42	A>V		No	ClinGen ExAC gnomAD
CA388838876 rs1157425035	43	E>K		No	ClinGen gnomAD
rs765896619 CA388838904	45	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765896619 CA7070045	45	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1393415961 CA388838917	46	P>L		No	ClinGen gnomAD
CA257264320 rs1035066257	47	T>I		No	ClinGen TOPMed gnomAD
rs763481628 CA7070047	47	T>P		No	ClinGen ExAC TOPMed gnomAD
rs752305683 CA257264339	48	S>*		No	ClinGen ExAC TOPMed gnomAD
rs752305683 CA7070049	48	S>L		No	ClinGen ExAC TOPMed gnomAD
CA7070051 rs763545842	49	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1209085685 CA388838935	49	S>P		No	ClinGen TOPMed gnomAD
rs753436215 CA7070052	50	S>A		No	ClinGen ExAC gnomAD
rs1232569254 CA388838942	50	S>C		No	ClinGen TOPMed gnomAD
rs1232569254 CA388838943	50	S>F		No	ClinGen TOPMed gnomAD
CA388838939 rs753436215	50	S>T		No	ClinGen ExAC gnomAD
rs778887885 CA388838946	51	G>A		No	ClinGen ExAC TOPMed gnomAD
CA388838945 rs757152967	51	G>C		No	ClinGen ExAC gnomAD
rs778887885 CA7070054	51	G>D		No	ClinGen ExAC TOPMed gnomAD
CA7070053 rs757152967	51	G>S		No	ClinGen ExAC gnomAD
CA388838959 rs200526577	53	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200526577 CA7070055	53	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7070056 rs758199252	54	G>C		No	ClinGen ExAC TOPMed gnomAD
CA388838964 rs1463693284	54	G>D		No	ClinGen gnomAD
CA7070057 rs758199252	54	G>S		No	ClinGen ExAC TOPMed gnomAD
CA388838969 rs1399862043	55	G>C		No	ClinGen TOPMed gnomAD
CA388838968 rs1399862043	55	G>R		No	ClinGen TOPMed gnomAD
CA388838967 rs1399862043	55	G>S		No	ClinGen TOPMed gnomAD
rs373380917 CA257264434	56	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA257264450 rs373380917	56	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7070058 rs747224471	56	A>T		No	ClinGen ExAC TOPMed gnomAD
rs373380917 CA7070059	56	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388838977 rs1457537173	57	G>C		No	ClinGen TOPMed
CA257264459 rs201405072	57	G>D		No	ClinGen Ensembl
CA388838976 rs1457537173	57	G>R		No	ClinGen TOPMed
CA7070062 rs776554800	58	K>E		No	ClinGen ExAC gnomAD
CA388838980 rs776554800	58	K>Q		No	ClinGen ExAC gnomAD
CA388838983 rs1162797220	58	K>R		No	ClinGen TOPMed gnomAD
rs1309084759 CA388838989	59	P>S		No	ClinGen gnomAD
CA388838994 rs1204750484	60	R>G		No	ClinGen gnomAD
rs770424499 CA388838996	60	R>H		No	ClinGen ExAC gnomAD
rs770424499 CA7070064	60	R>P		No	ClinGen ExAC gnomAD
CA7070066 rs773915083	61	E>*		No	ClinGen ExAC
CA388839003 rs1456195230	61	E>D		No	ClinGen TOPMed gnomAD
rs1406917642 CA388839007	62	E>Q		No	ClinGen gnomAD
CA7070068 rs376489246	63	K>E		No	ClinGen ESP TOPMed
CA388839018 rs1478639973	63	K>N		No	ClinGen gnomAD
rs3752105 VAR_062143 CA7070069	64	R>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7070070 rs3752105	64	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388839026 rs1430610505	65	T>A		No	ClinGen gnomAD
CA7070071 rs775169372	65	T>K		No	ClinGen ExAC gnomAD
CA7070073 rs74613026	66	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388839031 rs74613026	66	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388839034 rs1327993916	66	A>V		No	ClinGen TOPMed gnomAD
rs1390544933 CA388839036	67	L>Q		No	ClinGen TOPMed
rs753282717 CA7070074	67	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1214904167 CA388839043	68	S>N		No	ClinGen TOPMed gnomAD
CA388839039 rs1364020628	68	S>R		No	ClinGen gnomAD
rs1426016693 CA388839048	69	K>E		No	ClinGen TOPMed
rs1038572201 CA257264550	69	K>N		No	ClinGen TOPMed gnomAD
CA7070101 rs76186578	70	V>L		No	ClinGen ExAC gnomAD
rs1445354415 CA388839089	73	R>H		No	ClinGen gnomAD
CA7070103 rs756224010	74	R>C		No	ClinGen ExAC gnomAD
rs1375258703 CA388839096	74	R>H		No	ClinGen gnomAD
CA388839107 rs1237221357	76	P>L		No	ClinGen gnomAD
CA7070104 rs778022698	77	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7070105 rs778022698	77	P>R		No	ClinGen ExAC TOPMed gnomAD
CA257264803 rs950732167	77	P>S		No	ClinGen TOPMed gnomAD
CA7070107 rs779532379	78	G>D		No	ClinGen ExAC gnomAD
rs746160217 CA7070110	81	K>N		No	ClinGen ExAC gnomAD
CA388839132 rs1458387616	81	K>R		No	ClinGen gnomAD
rs1236492825 CA388839135	82	E>K		No	ClinGen gnomAD
rs1277347941 CA388839148	83	Q>R		No	ClinGen TOPMed
rs1243077307 CA388839168	86	E>G		No	ClinGen TOPMed
CA388839174 rs1199544946	87	Q>*		No	ClinGen gnomAD
CA388839183 rs1376834586	88	L>P		No	ClinGen gnomAD
CA7070113 rs761474818	89	R>C		No	ClinGen ExAC TOPMed gnomAD
CA388839187 rs1423818252	89	R>L		No	ClinGen gnomAD
CA388839194 rs1328676924	90	P>L		No	ClinGen gnomAD
CA388839191 rs1018570749	90	P>S		No	ClinGen TOPMed
CA257264873 rs1018570749	90	P>T		No	ClinGen TOPMed
rs1324725313 CA388839202	92	P>A		No	ClinGen gnomAD
CA388839205 rs1331062530	92	P>L		No	ClinGen gnomAD
CA388839206 rs1316394890	93	A>T		No	ClinGen gnomAD
CA388839219 rs191315480	94	H>Q		No	ClinGen 1000Genomes TOPMed gnomAD
rs1272302202 CA388839214	94	H>Y		No	ClinGen gnomAD
CA388839226 rs1256203812	95	D>E		No	ClinGen TOPMed gnomAD
CA388839223 rs1428491401	95	D>G		No	ClinGen TOPMed
rs762520134 CA388839220	95	D>N		No	ClinGen ExAC TOPMed gnomAD
rs762520134 CA7070116	95	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA388839241 rs1210533634	97	F>L		No	ClinGen gnomAD
CA388839246 rs1266540982	98	E>A		No	ClinGen gnomAD
rs1031182192 CA257264901	98	E>D		No	ClinGen TOPMed gnomAD
CA388839243 rs1594740239	98	E>K		No	ClinGen Ensembl
TCGA novel rs1194997507 CA388839257	99	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed gnomAD NCI-TCGA
rs1168152692 CA388839275	102	A>D		No	ClinGen gnomAD
CA388839272 rs1477290558	102	A>T		No	ClinGen gnomAD
rs1566718817 CA388839279	103	D>Y		No	ClinGen Ensembl
rs1258992514 CA388839289	104	L>P		No	ClinGen gnomAD
CA388839287 rs1419598132	104	L>V		No	ClinGen TOPMed gnomAD
CA388839294 rs1162130403	105	S>N		No	ClinGen gnomAD
rs987673954 CA257265904	106	L>F		No	ClinGen TOPMed
rs760603672 CA7070143	107	Y>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	108	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070145 rs754117857	108	P>L		No	ClinGen ExAC TOPMed gnomAD
rs754117857 CA388839330	108	P>R		No	ClinGen ExAC TOPMed gnomAD
rs764354121 CA7070144	108	P>S		No	ClinGen ExAC TOPMed gnomAD
CA7070146 rs757240245	109	H>Y		No	ClinGen ExAC gnomAD
rs940862875 CA257265951	110	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs750514540 CA7070148	111	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA388839377 rs556363515	116	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7070151 rs556363515	116	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755352707 CA7070152	119	R>G		No	ClinGen ExAC gnomAD
rs1308986380 CA388839417	121	P>L		No	ClinGen TOPMed
rs201039341 CA7070153	121	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1198663830 CA388839429	123	D>A		No	ClinGen gnomAD
CA7070157 rs770298894	125	L>P		No	ClinGen ExAC TOPMed gnomAD
CA388839446 rs1279173098	126	L>I		No	ClinGen gnomAD
rs1056239437 CA257266104	126	L>R		No	ClinGen TOPMed gnomAD
rs773891566 CA7070158	128	R>G		No	ClinGen ExAC TOPMed gnomAD
rs745412491 CA7070159	129	D>V		No	ClinGen ExAC gnomAD
TCGA novel	130	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070160 rs772119228	130	R>L		No	ClinGen ExAC gnomAD
CA7070162 rs760478961	131	F>L		No	ClinGen ExAC gnomAD
CA7070164 rs145367145	134	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070165 rs145367145	134	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070163 rs764011129	134	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	136	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070166 rs765414961	137	L>F		No	ClinGen ExAC TOPMed gnomAD
rs758468482 CA7070168	138	D>N		No	ClinGen ExAC gnomAD
rs1201002533 CA388839533	139	S>N		No	ClinGen gnomAD
rs1414710428 CA388839828	141	G>D		No	ClinGen gnomAD
CA388839872 rs1162658709	145	P>L		No	ClinGen gnomAD
CA388839878 rs1362405877	146	A>S		No	ClinGen gnomAD
rs529401037 CA7070194	148	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA388839907 rs1337937054	149	E>A		No	ClinGen TOPMed gnomAD
TCGA novel	149	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070195 rs757932269	150	F>L		No	ClinGen ExAC gnomAD
rs779685671 CA7070196	152	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	153	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070197 rs746554618	156	I>T		No	ClinGen ExAC gnomAD
rs1377871891 CA388839984	156	I>V		No	ClinGen gnomAD
CA7070198 rs768707129	162	R>S		No	ClinGen ExAC gnomAD
rs781046348 CA7070199	163	K>E		No	ClinGen ExAC gnomAD
rs747921994 CA7070200	165	D>Y		No	ClinGen ExAC gnomAD
rs1231134074 CA388840092	166	A>T		No	ClinGen TOPMed
rs1323495748 CA388840097	166	A>V		No	ClinGen TOPMed
rs1285832031 CA388840111	168	T>S		No	ClinGen gnomAD
rs547441846 CA257269078	170	S>N		No	ClinGen 1000Genomes gnomAD
rs773447969 CA388840131	171	I>M		No	ClinGen ExAC gnomAD
rs200349995 CA7070203	172	E>K	Variant assessed as Somatic; 0.0005544 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA388840143 rs1566731917	173	D>G		No	ClinGen Ensembl
rs1238442941 CA388840191	176	E>D		No	ClinGen gnomAD
CA7070225 rs567334744	183	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745879648 CA388840285	185	C>F		No	ClinGen ExAC gnomAD
rs745879648 CA7070227 COSM432178	185	C>Y	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA257269381 rs933735181	186	V>A		No	ClinGen TOPMed gnomAD
rs772074945 CA7070228	187	E>Q		No	ClinGen ExAC gnomAD
CA7070231 rs761063736	192	S>I		No	ClinGen ExAC TOPMed gnomAD
CA7070230 rs761063736	192	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	193	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs886782169 CA257269429	194	N>I		No	ClinGen TOPMed gnomAD
rs552671813 CA7070232	194	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA257269448 rs970739195	196	E>K		No	ClinGen Ensembl
CA7070234 rs1555368996	197	T>A		No	ClinGen Ensembl
rs1453268694 CA388840417	198	L>V		No	ClinGen gnomAD
rs754474639 CA7070238	200	G>E		No	ClinGen ExAC gnomAD
CA388840438 rs754474639	200	G>V		No	ClinGen ExAC gnomAD
rs1479235609 CA388840448	201	E>V		No	ClinGen gnomAD
rs41291207 CA388840487	204	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs41291207 CA7070239	204	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388840511 rs1293095374	206	T>I		No	ClinGen Ensembl
CA7070243 rs755974941	207	R>I		No	ClinGen ExAC TOPMed gnomAD
CA7070244 rs777756188	207	R>S		No	ClinGen ExAC TOPMed gnomAD
CA388840527 rs1394899357	208	E>Q		No	ClinGen gnomAD
CA257269573 rs920046854	209	L>F		No	ClinGen TOPMed gnomAD
rs920046854 CA388840538	209	L>V		No	ClinGen TOPMed gnomAD
CA388840553 rs1333972636	210	I>M		No	ClinGen TOPMed
rs1403512340 CA388840549	210	I>S		No	ClinGen gnomAD
rs1357202473 CA388840992	212	R>G		No	ClinGen gnomAD
CA7070267 rs577525359	212	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs369499398 CA7070268	213	R>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1487737592 CA388841031	215	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388841041 rs1566744018	216	P>L		No	ClinGen Ensembl
CA388841036 rs1242281350	216	P>S		No	ClinGen gnomAD
rs756993621 CA7070271	219	E>K		No	ClinGen ExAC gnomAD
CA388841122 rs1186228730	223	N>I		No	ClinGen gnomAD
rs1443388197 CA388841150	225	K>E		No	ClinGen gnomAD
CA7070275 rs780380394	226	L>F		No	ClinGen ExAC gnomAD
CA7070274 rs758544348	226	L>S		No	ClinGen ExAC gnomAD
CA257274837 rs903882660	230	R>I		No	ClinGen TOPMed
rs780071389 CA7070292	231	I>V		No	ClinGen ExAC gnomAD
CA257274844 rs936640071 COSM201615	232	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs751840581 CA7070293	232	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1054409672 CA257274858	234	E>Q		No	ClinGen TOPMed
CA388841310 rs755061369	236	R>*		No	ClinGen ExAC TOPMed gnomAD
CA7070294 rs755061369	236	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7070296 rs149323560	236	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070295 rs149323560	236	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070299 rs778406286	239	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7070298 rs143579155	239	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
rs749560057 CA7070300	240	R>S		No	ClinGen ExAC gnomAD
CA7070301 rs771333598	241	R>K		No	ClinGen ExAC gnomAD
CA7070302 rs1555371086	243	E>Q		No	ClinGen Ensembl
rs1175839376 CA388841370	244	L>I		No	ClinGen gnomAD
rs1293598191 CA388841389	246	K>R		No	ClinGen TOPMed
CA7070304 rs774953253	248	R>C		No	ClinGen ExAC TOPMed gnomAD
rs768334907 CA7070306	248	R>H		No	ClinGen ExAC TOPMed gnomAD
rs774953253 CA7070305	248	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1467187025 CA388841412	250	R>Q		No	ClinGen TOPMed gnomAD
rs186674806 CA7070308	250	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1171490165 CA388841429	252	E>D		No	ClinGen gnomAD
CA7070310 rs765100910	253	E>K		No	ClinGen ExAC TOPMed
CA388841442 rs1487322346	254	K>R		No	ClinGen TOPMed
rs1460461579 CA388841456	255	R>K		No	ClinGen gnomAD
CA257274980 rs923716045	257	R>K		No	ClinGen Ensembl
CA7070313 rs773204437	258	R>G		No	ClinGen ExAC gnomAD
rs1356352990 CA388841487	258	R>K		No	ClinGen TOPMed
rs762614352 CA7070315	258	R>S		No	ClinGen ExAC gnomAD
rs766221879 CA7070316	259	E>K		No	ClinGen ExAC gnomAD
TCGA novel	260	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388841505 rs1341997949	260	E>K		No	ClinGen gnomAD
CA388841519 rs1218653178	261	E>K		No	ClinGen gnomAD
rs751362107 CA7070317	262	R>G		No	ClinGen ExAC gnomAD
CA388841534 rs1307425169	262	R>K		No	ClinGen gnomAD
rs1230687399 CA388841554	263	C>*		No	ClinGen TOPMed
CA388841543 rs1267774473	263	C>S		No	ClinGen gnomAD
TCGA novel	263	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388841548 rs1490603138	263	C>Y		No	ClinGen gnomAD
CA388841560 rs1222216705	264	K>E		No	ClinGen gnomAD
CA257275002 rs576285496	264	K>R		No	ClinGen gnomAD
rs1478957221 CA388841575	265	K>T		No	ClinGen TOPMed gnomAD
CA388841588 rs755220838	266	K>I		No	ClinGen ExAC TOPMed
CA7070321 rs755220838	266	K>R		No	ClinGen ExAC TOPMed
rs1297559348 CA388841597	267	E>K		No	ClinGen TOPMed
rs767420916	267	E>R	Variant assessed as Somatic; 0.0001008 impact. Variant assessed as Somatic; 5.042e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA388841614 rs1166758574	268	T>A		No	ClinGen gnomAD
CA7070324 rs767918514	268	T>I		No	ClinGen ExAC
rs767918514 CA257275033	268	T>R		No	ClinGen ExAC
rs752815880 CA7070325	269	D>G		No	ClinGen ExAC gnomAD
rs756279155 CA7070327	271	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs778078710 CA7070328	273	K>T		No	ClinGen ExAC gnomAD
CA388841692 rs1400265517	274	I>T		No	ClinGen gnomAD
CA388841701 rs1359187172	275	A>S		No	ClinGen gnomAD
rs1315394098 CA388841735	278	E>*		No	ClinGen gnomAD
rs1290094019 CA388841756	281	I>F		No	ClinGen gnomAD
rs376741542 CA7070333	282	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs893429771 CA257275097	282	K>R		No	ClinGen Ensembl
CA257282213 rs940687838	285	K>*		No	ClinGen TOPMed
rs943077313 CA257282219	288	E>K		No	ClinGen TOPMed
CA7070348 rs757773931	289	K>E		No	ClinGen ExAC TOPMed gnomAD
CA257282230 rs143806139	291	E>*		No	ClinGen ESP TOPMed gnomAD
rs560113415 CA257282236	292	E>*		No	ClinGen 1000Genomes TOPMed
rs560113415 CA257282234	292	E>K		No	ClinGen 1000Genomes TOPMed
CA388842030 rs1203753467	293	P>S		No	ClinGen TOPMed
rs1157808242 CA388842039	294	T>I		No	ClinGen gnomAD
CA7070351 rs746173465	299	K>*		No	ClinGen ExAC gnomAD
rs1415863369 CA388842083	301	R>G		No	ClinGen gnomAD
rs758765255 CA7070352	301	R>T		No	ClinGen ExAC gnomAD
rs1357487610 CA388842101	303	E>D		No	ClinGen TOPMed gnomAD
rs1404797409 CA388842103	304	E>K		No	ClinGen gnomAD
CA7070354 rs747818618	305	I>M		No	ClinGen ExAC gnomAD
CA7070353 rs376399019	305	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070356 rs777308493	306	D>G		No	ClinGen ExAC gnomAD
TCGA novel	306	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388842128 rs1304481644	307	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	309	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355965831 CA388842154	311	K>N		No	ClinGen TOPMed gnomAD
CA388842164 rs1410446045	313	E>*		No	ClinGen TOPMed
rs1221216648 CA388842180	315	C>Y		No	ClinGen TOPMed gnomAD
CA7070358 rs770888169	316	A>S		No	ClinGen ExAC gnomAD
rs1201892006 CA388842192	317	P>S		No	ClinGen gnomAD
CA7070362 rs775808542	318	G>S		No	ClinGen ExAC TOPMed gnomAD
rs3752107 CA7070363	319	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764287690 CA7070364	320	V>I		No	ClinGen ExAC gnomAD
rs761811674 CA7070366	321	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs761811674 CA257282296	321	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7070367 rs765709351	322	K>N		No	ClinGen ExAC gnomAD
rs143253585 CA7070368	323	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA388842235 rs377378655	325	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070369 rs377378655	325	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs3993409 CA7070371	326	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7070372 rs755787826	326	M>T		No	ClinGen ExAC TOPMed gnomAD
COSM3667262 CA7070370 rs3993409	326	M>V	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA257282337 rs958502923	328	G>A		No	ClinGen Ensembl
rs139333511 CA7070373	328	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA388842254 rs139333511	328	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA388842262 rs1439063173	329	S>L		No	ClinGen TOPMed gnomAD
rs3993410 CA257282339	331	E>K		No	ClinGen Ensembl
rs778956714 CA7070376	332	E>D		No	ClinGen ExAC gnomAD
CA7070375 rs564771391	332	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA257282350 rs991010360	333	P>A		No	ClinGen gnomAD
CA388842295 rs991010360	333	P>S		No	ClinGen gnomAD
CA7070378 rs531937279	336	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7070377 rs745825993	336	T>S		No	ClinGen ExAC TOPMed gnomAD
CA388842623 rs1341903534	338	H>P		No	ClinGen TOPMed
rs375258220 CA7070404	340	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs766815591 CA7070406	341	S>R		No	ClinGen ExAC gnomAD
rs367909816 CA388842670	344	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	344	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756961916 CA7070411	346	R>S		No	ClinGen ExAC gnomAD
CA7070409 rs767798245	346	R>W		No	ClinGen ExAC gnomAD
CA388842701 rs1194396906	349	E>A		No	ClinGen TOPMed
CA7070413 rs371654561	349	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA388842707 rs1447908068	350	R>*		No	ClinGen TOPMed gnomAD
CA7070415 rs780099139	350	R>S		No	ClinGen ExAC TOPMed gnomAD
CA7070414 rs757983101	350	R>T		No	ClinGen ExAC gnomAD
rs746942506 CA7070416	351	S>C		No	ClinGen ExAC gnomAD
rs746942506 CA388842714	351	S>F		No	ClinGen ExAC gnomAD
rs1221243845 CA388842747	355	E>D		No	ClinGen TOPMed gnomAD
rs866183657 CA257284579	361	Y>D		No	ClinGen Ensembl
CA388842793 rs1335924754	362	H>L		No	ClinGen gnomAD
CA388842798 rs1392862626	363	V>M		No	ClinGen gnomAD
CA7070419 rs748043391	364	D>N		No	ClinGen ExAC gnomAD
rs368934136 CA7070421	366	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070422 rs749299960	367	R>G		No	ClinGen ExAC gnomAD
CA7070423 rs771034163	367	R>S		No	ClinGen ExAC gnomAD
CA388842829 rs1594845025	368	R>G		No	ClinGen Ensembl
CA7070424 rs371412905	369	H>Y		No	ClinGen ESP ExAC gnomAD
CA388842843 rs1263011178	370	R>G		No	ClinGen gnomAD
CA7070426 rs759940081	370	R>I		No	ClinGen ExAC TOPMed gnomAD
CA7070425 rs759940081	370	R>K		No	ClinGen ExAC TOPMed gnomAD
CA7070427 rs145387476	371	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs200073551 CA7070428	372	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388842867 rs200728824	373	H>Q		No	ClinGen TOPMed gnomAD
rs374285151 CA7070430	374	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388842891 rs1403779574	377	R>P		No	ClinGen gnomAD
CA7070431 rs112653680	377	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1171999457 CA388842925	382	S>N		No	ClinGen TOPMed
rs1355405550 CA388842927	382	S>R		No	ClinGen Ensembl
CA388842936 rs1594845241	384	D>N		No	ClinGen Ensembl
CA388842954 rs1395435646	386	Q>*		No	ClinGen gnomAD
CA388842983 rs1284763155	390	K>E		No	ClinGen gnomAD
TCGA novel	391	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754867855 CA7070434	391	G>E		No	ClinGen ExAC gnomAD
rs781249757 CA7070435	392	P>S		No	ClinGen ExAC gnomAD
rs1280855111 CA388843004	393	G>A		No	ClinGen gnomAD
rs1280855111 CA388843003	393	G>D		No	ClinGen gnomAD
rs777934829 CA7070438	395	D>A		No	ClinGen ExAC TOPMed gnomAD
rs755908505 CA7070437	395	D>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	397	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070440 rs143978425	398	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1271251801 CA388843051	400	G>E		No	ClinGen gnomAD
CA388843057 rs746015015	401	S>N		No	ClinGen ExAC gnomAD
CA7070442 rs746015015	401	S>T		No	ClinGen ExAC gnomAD
CA388843067 rs1566773627	402	Q>R		No	ClinGen Ensembl
CA388843093 rs1237393669	403	D>G		No	ClinGen TOPMed
CA7070444 rs772399317	403	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1011831369 CA257284715	405	G>R		No	ClinGen TOPMed gnomAD
CA7070448 rs544447756	407	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769164771 CA7070447	407	P>S		No	ClinGen ExAC gnomAD
rs766121292 CA7070450	409	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1227258446	409	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140894742 CA7070451	411	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070452 rs759100983	413	R>K		No	ClinGen ExAC gnomAD
CA7070453 rs767291578	415	G>V		No	ClinGen ExAC gnomAD
CA7070455 rs529954434	417	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7070456 rs777523591	417	A>V		No	ClinGen ExAC TOPMed gnomAD
CA388843354 rs1486867009	422	D>N		No	ClinGen gnomAD
CA388843371 rs1187208983	423	S>G		No	ClinGen gnomAD
CA7070460 rs745864012	424	P>L		No	ClinGen ExAC
rs148684815 COSM106481 CA257284823	424	P>S	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA388843417 rs1165233574	426	P>R		No	ClinGen TOPMed gnomAD
rs144828938 CA7070464	427	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070465 rs769324458	428	K>E		No	ClinGen ExAC gnomAD
COSM945700 CA388843455 rs1346627869	430	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs777130407 CA7070466	430	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs762327211 CA7070467	432	A>E		No	ClinGen ExAC gnomAD
CA257284858 rs912259623	433	N>K		No	ClinGen TOPMed gnomAD
CA7070468 rs770433580	434	K>E		No	ClinGen ExAC gnomAD
CA7070485 rs770227782	435	D>E		No	ClinGen ExAC TOPMed gnomAD
CA7070486 rs773827734	436	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA388843649 rs1470399560	436	R>W		No	ClinGen gnomAD
rs1481104736 CA388843661	438	A>D		No	ClinGen gnomAD
CA388843660 rs1409355590	438	A>S		No	ClinGen gnomAD
CA388843658 rs1409355590	438	A>T		No	ClinGen gnomAD
CA7070488 rs771664385	440	Q>*		No	ClinGen ExAC gnomAD
rs760240570 CA7070490	443	D>H		No	ClinGen ExAC gnomAD
rs763948700 CA7070491	443	D>V		No	ClinGen ExAC gnomAD
CA388843703 rs1443391816	445	G>R		No	ClinGen gnomAD
CA388843714 rs1249812353	446	A>V		No	ClinGen TOPMed
CA7070492 rs776576957	447	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7070493 rs761464068	447	R>H		No	ClinGen ExAC TOPMed gnomAD
rs750224486 CA7070495	449	R>*		No	ClinGen ExAC gnomAD
rs370142973 CA7070497	449	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370142973 CA7070496	449	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7070498 rs118093178	450	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373072777 CA7070500	451	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs748713506 CA7070501	451	R>L		No	ClinGen ExAC TOPMed gnomAD
rs748713506 CA388843747	451	R>P		No	ClinGen ExAC TOPMed gnomAD
CA388843746 rs748713506	451	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7070506 rs200586196	455	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7070507 rs746478058	456	N>Y		No	ClinGen ExAC gnomAD
CA7070508 rs201229742	457	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	457	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776164523 CA7070510	459	I>F		No	ClinGen ExAC TOPMed gnomAD
CA388843832 rs776164523	459	I>L		No	ClinGen ExAC TOPMed gnomAD
CA388843861 rs1396020199	461	K>*		No	ClinGen TOPMed
CA257286221 rs201743180	464	G>R		No	ClinGen TOPMed gnomAD
CA7070514 rs773046796 COSM3417402	465	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA388843913 rs773046796	465	S>W		No	ClinGen ExAC TOPMed gnomAD
CA388843921 rs1340049564	466	G>E		No	ClinGen gnomAD
TCGA novel	467	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7070516 rs369708380	467	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA388843948 rs1165158917	469	P>S		No	ClinGen gnomAD
rs751861679 CA7070517	470	E>K		No	ClinGen ExAC gnomAD
CA7070518 rs759642355	471	K>R		No	ClinGen ExAC TOPMed gnomAD
rs767684952 CA7070519	473	E>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	473	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767684952 CA257286264	473	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA7070521 rs752763280	475	A>V		No	ClinGen ExAC TOPMed

No associated diseases with Q9H1J1

1 regional properties for Q9H1J1

Type	Name	Position	InterPro Accession
domain	UPF3 domain	68 - 225	IPR005120

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Shuttling between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
exon-exon junction complex	A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
telomeric DNA binding	Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.

3 GO annotations of biological process

Name	Definition
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nucleocytoplasmic transport	The directed movement of molecules between the nucleus and the cytoplasm.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	Homo sapiens (Human)	PR

10	20	30	40	50	60
MRSEKEGAGG	LRAAVAARGP	SGREKLSALE	VQFHRDSQQQ	EAETPPTSSS	GCGGGAGKPR
70	80	90	100	110	120
EEKRTALSKV	VIRRLPPGLT	KEQLEEQLRP	LPAHDYFEFF	AADLSLYPHL	YSRAYINFRN
130	140	150	160	170	180
PDDILLFRDR	FDGYIFLDSK	GLEYPAVVEF	APFQKIAKKK	LRKKDAKTGS	IEDDPEYKKF
190	200	210	220	230	240
LETYCVEEEK	TSANPETLLG	EMEAKTRELI	ARRTTPLLEY	IKNRKLEKQR	IREEKREERR
250	260	270	280	290	300
RRELEKKRLR	EEEKRRRREE	ERCKKKETDK	QKKIAEKEVR	IKLLKKPEKG	EEPTTEKPKE
310	320	330	340	350	360
RGEEIDTGGG	KQESCAPGAV	VKARPMEGSL	EEPQETSHSG	SDKEHRDVER	SQEQESEAQR
370	380	390	400	410	420
YHVDDGRRHR	AHHEPERLSR	RSEDEQRWGK	GPGQDRGKKG	SQDSGAPGEA	MERLGRAQRC
430	440	450	460	470
DDSPAPRKER	LANKDRPALQ	LYDPGARFRA	RECGGNRRIC	KAEGSGTGPE	KREEAE