AiPD: Autoinhibited Protein Database

Q9GZU8

Gene name	PSME3IP1
Protein name	PSME3-interacting protein
Names	NEFA-interacting nuclear protein NIP30, PA28G-interacting protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:80011
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-91 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

16-91 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9GZU8

Entry ID	Method	Resolution	Chain	Position	Source
7W59	EM	360 A	X	1-254	PDB
7W5A	EM	360 A	X	1-254	PDB
AF-Q9GZU8-F1	Predicted				AlphaFoldDB

174 variants for Q9GZU8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA8074344 rs764383917	2	D>V		No	ClinGen ExAC TOPMed gnomAD
CA8074341 rs770389028	5	D>G		No	ClinGen ExAC gnomAD
CA8074340 rs760094794	6	D>G		No	ClinGen ExAC TOPMed gnomAD
CA396023128 rs1164956183	6	D>Y		No	ClinGen gnomAD
rs925698743 CA281541253	9	L>R		No	ClinGen Ensembl
CA396023096 rs1438230732	11	I>V		No	ClinGen TOPMed gnomAD
rs776887226 CA8074338	14	R>K		No	ClinGen ExAC gnomAD
rs1597720822 CA396023068	15	F>V		No	ClinGen Ensembl
CA396023054 rs1259343193	17	S>P		No	ClinGen gnomAD
rs750543347 CA8074337	20	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1192705820 CA396023016	22	D>E		No	ClinGen gnomAD
CA8074335 rs777993320	24	R>Q		No	ClinGen ExAC gnomAD
CA8074336 rs535488737 COSM971808	24	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs771766544 CA396023002	25	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748040990 CA8074333	25	R>H		No	ClinGen ExAC gnomAD
CA8074334 rs771766544	25	R>S		No	ClinGen ExAC gnomAD
rs778552812 CA8074332	27	R>K		No	ClinGen ExAC gnomAD
rs754949848 CA8074331	28	R>W		No	ClinGen ExAC gnomAD
rs1469640551 CA396022978	29	Q>*		No	ClinGen gnomAD
CA396022971 rs1220332816	30	E>K		No	ClinGen gnomAD
rs753735386 CA8074330	31	E>K		No	ClinGen ExAC gnomAD
CA396022946 rs1203694272	33	E>Q		No	ClinGen gnomAD
CA396022924 COSM1177217 rs779562242	36	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1274438311 CA396022923	36	R>Q		No	ClinGen TOPMed gnomAD
rs1238821799 CA396022891	40	D>E		No	ClinGen TOPMed
CA8074328 rs755566928	41	P>A		No	ClinGen ExAC TOPMed gnomAD
rs886943674 CA281540566	43	E>A		No	ClinGen Ensembl
rs1314894479 CA396022815	44	C>G		No	ClinGen TOPMed gnomAD
CA8074304 rs755335453	44	C>Y		No	ClinGen ExAC gnomAD
CA396022772 rs1363471289	47	E>K		No	ClinGen gnomAD
rs1567419836 CA396022735	49	Y>C		No	ClinGen Ensembl
rs546658164 CA8074303	51	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396022663 rs1409960923	53	S>C		No	ClinGen gnomAD
CA281540557 rs931233633	54	L>Q		No	ClinGen Ensembl
rs1567419632 CA396022638	55	Y>C		No	ClinGen Ensembl
CA396022622 rs1475901642	56	E>G		No	ClinGen TOPMed
CA396022604 rs1485325739	57	R>S		No	ClinGen gnomAD
CA396022579 rs1188173350	59	Q>*		No	ClinGen TOPMed
TCGA novel	60	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA281540555 rs1039747090	62	K>E		No	ClinGen Ensembl
CA281540546 rs528576294	62	K>N		No	ClinGen 1000Genomes
rs942639690 CA281540550	62	K>R		No	ClinGen Ensembl
rs1169665076 CA396022491	64	R>G		No	ClinGen gnomAD
CA8074298 rs762119081	66	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs11555755 CA281540526	66	Q>R		No	ClinGen Ensembl
rs774379565 CA8074295	69	Y>C		No	ClinGen ExAC gnomAD
CA396022354 rs1356681236	70	E>D		No	ClinGen gnomAD
rs749152481 CA8074293	70	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396022330 rs1297815220	72	Q>E		No	ClinGen TOPMed
rs775256303 CA8074292	72	Q>P		No	ClinGen ExAC gnomAD
CA8074291 rs369877166	73	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1289649512 CA396022282	74	K>R		No	ClinGen TOPMed gnomAD
CA396022286 rs1289649512	74	K>T		No	ClinGen TOPMed gnomAD
rs986876953 CA281540463	76	K>E		No	ClinGen Ensembl
CA8074263 rs771898297	78	M>I		No	ClinGen ExAC gnomAD
rs371988638 CA8074264	78	M>V		No	ClinGen ESP ExAC TOPMed
TCGA novel	79	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1442007848 CA396022107	85	D>N		No	ClinGen gnomAD
CA396022102 rs1371422399	85	D>V		No	ClinGen gnomAD
CA8074261 rs780589903	87	T>I		No	ClinGen ExAC gnomAD
CA8074262 rs747764245	87	T>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	91	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375518314 CA8074260	95	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8074259 rs781655808	95	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8074258 rs781655808	95	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1285910919 CA396022028	96	Q>P		No	ClinGen TOPMed
rs1379759643 CA396022019	97	Q>R		No	ClinGen TOPMed
rs757773647 CA8074257	98	E>G		No	ClinGen ExAC gnomAD
rs764131026 CA8074255	100	I>T		No	ClinGen ExAC TOPMed
CA396022002 rs1465818955	100	I>V		No	ClinGen TOPMed gnomAD
CA281540193 rs180702754	102	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1170615485 CA396021978	103	Q>*		No	ClinGen gnomAD
CA396021970 rs1454473075	104	R>*		No	ClinGen gnomAD
CA8074253 rs752864583 COSM275061	104	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765089690 CA8074252	106	E>D		No	ClinGen ExAC gnomAD
CA8074251 rs759183067	109	L>M		No	ClinGen ExAC TOPMed gnomAD
CA396021892 rs770830499	112	L>V		No	ClinGen ExAC TOPMed gnomAD
rs569865674 CA8074248	115	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1484731642 CA396021843	116	R>K		No	ClinGen gnomAD
CA281537786 rs890162641	117	N>S		No	ClinGen Ensembl
CA396020709 CA396020712 rs1386110621	118	N>K		No	ClinGen gnomAD
rs1346298809 CA396020686	120	K>R		No	ClinGen TOPMed gnomAD
CA396020653 rs1161602168	122	V>F		No	ClinGen TOPMed
CA8074223 rs767141143	124	I>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	125	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1453171401 CA396020585	126	Q>R		No	ClinGen TOPMed
COSM971805 rs761482807 CA8074222	129	K>R	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1287131015 CA396020453	132	V>A		No	ClinGen TOPMed
CA396020449 rs1597658936	133	E>K		No	ClinGen Ensembl
rs1473808420 CA396020360	137	T>I		No	ClinGen gnomAD
TCGA novel	138	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143746498 CA8074221 CA396020328	141	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768246575 CA8074220	141	I>T		No	ClinGen ExAC TOPMed gnomAD
rs143746498 CA281537776	141	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748942436 CA8074219	144	K>E		No	ClinGen ExAC gnomAD
CA8074218 rs776894654	145	N>D		No	ClinGen ExAC gnomAD
rs1353921028 CA396020240	145	N>K		No	ClinGen TOPMed
CA396020229 rs746174590	146	K>R		No	ClinGen TOPMed gnomAD
CA281537766 rs746174590	146	K>T		No	ClinGen TOPMed gnomAD
CA8074215 rs370469445	150	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs370469445 CA8074216	150	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8074214 rs201042159	150	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1429538464 CA396020108	154	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA396020061 rs1483572383	159	H>P		No	ClinGen TOPMed
rs1373925463 CA396020062	159	H>Y		No	ClinGen gnomAD
CA396020044 rs1597658001	161	S>N		No	ClinGen Ensembl
CA281536211 rs1038410383	163	E>G		No	ClinGen Ensembl
CA8074190 rs756393274	166	N>I		No	ClinGen ExAC gnomAD
rs750295435 CA8074189	167	S>G		No	ClinGen ExAC gnomAD
CA281536195 rs200359429	168	V>A		No	ClinGen 1000Genomes
rs781107141 CA8074188	168	V>M		No	ClinGen ExAC TOPMed gnomAD
rs757294337 CA8074187	169	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8074185 rs564050683	173	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8074183 rs372644692	178	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1174575894 CA396019588	179	D>N		No	ClinGen TOPMed
rs1466217467 CA396019564	182	Q>K		No	ClinGen TOPMed
rs1352899164 CA396019218	184	P>T		No	ClinGen gnomAD
rs377190829 CA8074169	185	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8074168 rs777831024	188	K>N		No	ClinGen ExAC gnomAD
CA8074167 rs758251659	190	L>F		No	ClinGen ExAC gnomAD
CA396019102 rs1597537374	192	N>T		No	ClinGen Ensembl
CA396019089 rs1597537320	193	T>P		No	ClinGen Ensembl
rs1597537200 CA396019053	195	L>R		No	ClinGen Ensembl
CA8074163 rs374828952	196	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs200333306 CA8074162 CA396019022	196	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA396019002 rs762305303	197	G>A		No	ClinGen ExAC gnomAD
CA8074161 rs762305303	197	G>D		No	ClinGen ExAC gnomAD
rs1467325545 COSM435420 CA396018985	198	P>L	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs774568604 CA8074160	198	P>S		No	ClinGen ExAC gnomAD
CA396018981 rs1597536679	199	S>P		No	ClinGen Ensembl
rs763341398 CA8074158	200	I>M		No	ClinGen ExAC gnomAD
CA8074159 rs769256035	200	I>T		No	ClinGen ExAC TOPMed gnomAD
CA396018932 rs1354008835	202	C>R		No	ClinGen TOPMed
rs1282138583 CA396018855	206	A>T		No	ClinGen TOPMed gnomAD
CA396018821 rs1260464725	208	C>Y		No	ClinGen gnomAD
CA396018813 rs1209759183	209	I>V		No	ClinGen TOPMed gnomAD
CA281531726 rs867281910	210	G>D		No	ClinGen Ensembl
CA8074154 rs776923728	210	G>S		No	ClinGen ExAC gnomAD
CA8074153 rs771049188	211	I>V		No	ClinGen ExAC gnomAD
CA396018766 rs1380692286	215	L>V		No	ClinGen gnomAD
CA396018761 rs1361562031	216	G>S		No	ClinGen gnomAD
CA8074150 rs758399641	217	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1435559772 CA396018744	218	Y>F		No	ClinGen TOPMed gnomAD
CA8074149 rs570931234	219	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA396018738 rs1390632236	219	S>T		No	ClinGen TOPMed gnomAD
rs754426999 CA8074147	220	G>R		No	ClinGen ExAC gnomAD
rs1284667717 CA396018683	223	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1247050011 CA396018656	225	E>K		No	ClinGen gnomAD
CA396018626 rs1223060883	227	S>G		No	ClinGen TOPMed
rs1597534811 CA396018605	228	S>L		No	ClinGen Ensembl
TCGA novel	229	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8074144 rs755700823	229	D>G		No	ClinGen ExAC gnomAD
rs1213586579 CA396018565	231	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA281531683 rs370700301	232	G>A		No	ClinGen ESP TOPMed
CA8074142 rs764328745	234	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1476550709 CA396018505	235	N>S		No	ClinGen TOPMed
rs763543191 CA8074141	236	A>V		No	ClinGen ExAC gnomAD
CA8074138 rs759752010	238	G>R		No	ClinGen ExAC TOPMed gnomAD
rs776836330 CA8074137	240	I>V		No	ClinGen ExAC gnomAD
CA8074135 rs747167334	243	S>T		No	ClinGen ExAC gnomAD
rs1294718522 CA396018357	246	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1460017504 CA396018355	246	R>P		No	ClinGen gnomAD
rs1165506913 CA396018352	247	T>A		No	ClinGen TOPMed
rs554043068 CA281531630	247	T>N		No	ClinGen Ensembl
rs771715346 CA8074133	248	N>H		No	ClinGen ExAC gnomAD
rs751404485 CA8074132	248	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1393603140 CA396018340	249	T>A		No	ClinGen TOPMed gnomAD
CA8074131 rs778889751	249	T>I		No	ClinGen ExAC gnomAD
CA396018324 rs1301750285	251	L>H		No	ClinGen TOPMed
CA8074128 rs779401733	252	E>K		No	ClinGen ExAC gnomAD
CA396018312 rs1275491750	253	A>G		No	ClinGen gnomAD
CA396018314 rs1480345420	253	A>S		No	ClinGen gnomAD
rs1275491750 CA396018313	253	A>V		No	ClinGen gnomAD
rs755824856 CA8074127	254	P>A		No	ClinGen ExAC gnomAD

No associated diseases with Q9GZU8

1 regional properties for Q9GZU8

Type	Name	Position	InterPro Accession
domain	FAM192A/Fyv6, N-terminal	15 - 116	IPR019331

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name	Definition
negative regulation of proteasomal protein catabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MDGGDDGNLI	IKKRFVSEAE	LDERRKRRQE	EWEKVRKPED	PEECPEEVYD	PRSLYERLQE
70	80	90	100	110	120
QKDRKQQEYE	EQFKFKNMVR	GLDEDETNFL	DEVSRQQELI	EKQRREEELK	ELKEYRNNLK
130	140	150	160	170	180
KVGISQENKK	EVEKKLTVKP	IETKNKFSQA	KLLAGAVKHK	SSESGNSVKR	LKPDPEPDDK
190	200	210	220	230	240
NQEPSSCKSL	GNTSLSGPSI	HCPSAAVCIG	ILPGLGAYSG	SSDSESSSDS	EGTINATGKI
250
VSSIFRTNTF	LEAP