AiPD: Autoinhibited Protein Database

Q9GZU0

Gene name	C6orf62 (XTP12, Nbla00237)
Protein name	Uncharacterized protein C6orf62
Names	HBV X-transactivated gene 12 protein, HBV XAg-transactivated protein 12
Species	Homo sapiens (Human)
KEGG Pathway	hsa:81688
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-53 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9GZU0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9GZU0-F1	Predicted				AlphaFoldDB

131 variants for Q9GZU0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs778734904 CA3658739	4	P>S		No	ClinGen ExAC gnomAD
rs754899580 CA3658738	5	N>D		No	ClinGen ExAC gnomAD
rs1424550165 CA362989733	5	N>T		No	ClinGen gnomAD
CA3658737 rs140541841	6	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1362709940 CA362989628	9	K>T		No	ClinGen TOPMed gnomAD
rs767225153 CA362989598	11	A>S		No	ClinGen ExAC TOPMed gnomAD
rs767225153 CA3658733	11	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3658732 rs147608879	12	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1488565763 CA362989504	16	R>C		No	ClinGen gnomAD
CA362989474 rs1335776849	17	A>S		No	ClinGen TOPMed
rs1338197292 CA362989444	18	Q>*		No	ClinGen TOPMed
rs1446577985 CA362989296	22	K>R		No	ClinGen TOPMed
CA362989219 rs1348548232	25	S>A		No	ClinGen gnomAD
TCGA novel	25	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1328650110 CA362988938	35	Y>N		No	ClinGen gnomAD
CA3658726 rs766197948	37	A>V		No	ClinGen ExAC TOPMed gnomAD
rs200345046 CA362988863	39	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs200345046 CA3658725	39	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA3658724 rs772288076	40	F>L		No	ClinGen ExAC gnomAD
TCGA novel	42	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	45	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3658696 rs756082764	46	K>N		No	ClinGen ExAC gnomAD
CA362988043 rs1462652990	55	V>I		No	ClinGen gnomAD
CA136182439 rs200360611	56	I>V		No	ClinGen Ensembl
CA3658695 rs148471432	57	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA3658694 rs376277860	60	T>A		No	ClinGen ESP ExAC gnomAD
rs768745962 CA136182420	60	T>K		No	ClinGen Ensembl
TCGA novel	69	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362987922 rs1285373048	69	K>T		No	ClinGen gnomAD
rs777223686 CA3658691	70	G>D		No	ClinGen ExAC gnomAD
CA362987894 rs1581399460	72	R>Q		No	ClinGen Ensembl
rs1409224468 CA362987877	73	D>E		No	ClinGen gnomAD
CA362987889 rs1355965191	73	D>N		No	ClinGen gnomAD
rs1326591804 CA362987885	73	D>V		No	ClinGen gnomAD
rs754153171 CA3658689	78	L>S		No	ClinGen ExAC gnomAD
TCGA novel	79	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3658688 rs766901820	80	S>G		No	ClinGen ExAC gnomAD
CA136182391 rs368449457	80	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs368449457 CA3658687	80	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1183112799 CA362987744	82	L>V		No	ClinGen gnomAD
CA3658686 rs750547527	86	Q>R		No	ClinGen ExAC gnomAD
rs1180105363 CA362987640	87	K>N		No	ClinGen gnomAD
rs1386901358 CA362987604	89	V>G		No	ClinGen TOPMed
rs1225309945 CA362987537	94	A>S		No	ClinGen gnomAD
COSM3430372 COSM3430371 CA136182343 rs957447903	96	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1375063401 CA362987449	98	Q>H		No	ClinGen TOPMed gnomAD
rs907073316 CA136182312	98	Q>R		No	ClinGen TOPMed
rs1277336825 CA362987422	99	S>C		No	ClinGen gnomAD
CA362987393 rs1331420012	100	M>T		No	ClinGen gnomAD
TCGA novel	104	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764420342 CA3658653	107	C>G		No	ClinGen ExAC gnomAD
CA362986186 rs1487153492	108	T>I		No	ClinGen gnomAD
CA362986139 rs1239827431	110	E>A		No	ClinGen TOPMed gnomAD
rs1239827431 CA362986140	110	E>G		No	ClinGen TOPMed gnomAD
CA362986131 rs1214519614	111	M>V		No	ClinGen gnomAD
CA3658651 rs775483537	112	D>G		No	ClinGen ExAC gnomAD
CA3658652 rs763245732	112	D>N		No	ClinGen ExAC gnomAD
CA3658650 rs565112775	113	F>C		No	ClinGen 1000Genomes ExAC gnomAD
CA362986075 rs1322495041	114	I>F		No	ClinGen gnomAD
VAR_050803 CA136180608 rs34238213	116	W>C		No	ClinGen UniProt Ensembl dbSNP
rs776643289 CA3658648	119	N>H		No	ClinGen ExAC gnomAD
rs1302389468 CA362986039	119	N>S		No	ClinGen TOPMed
CA3658646 rs746559542	123	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	124	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866963179 CA136180582	125	V>F		No	ClinGen TOPMed
rs866963179 CA362985998	125	V>I		No	ClinGen TOPMed
rs1167237437 CA362985983	127	L>F		No	ClinGen gnomAD
CA362985962 COSM1471895 rs1220898270	130	S>C	Variant assessed as Somatic; impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA136180532 rs528364778	133	K>E		No	ClinGen 1000Genomes
rs1291576276 CA362985941	133	K>R		No	ClinGen TOPMed
CA3658641 rs756472666	134	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA362985926 rs1430786153	135	S>C		No	ClinGen gnomAD
CA136180521 rs112053740	136	D>G		No	ClinGen Ensembl
CA362985904 rs1418064750	138	P>L		No	ClinGen gnomAD
CA136180510 rs35050510 VAR_050804	140	R>S		No	ClinGen UniProt Ensembl dbSNP
rs746172712 CA3658640	142	V>L		No	ClinGen ExAC gnomAD
rs1244463356 CA362985877	143	Q>E		No	ClinGen gnomAD
CA3658619 rs757841054	144	A>T		No	ClinGen ExAC gnomAD
CA3658617 rs539000261	149	H>L		No	ClinGen 1000Genomes ExAC gnomAD
rs758568134 CA3658616	150	H>R		No	ClinGen ExAC gnomAD
CA362984823 rs1193896578	154	E>Q		No	ClinGen TOPMed
CA136175984 rs975242756	155	K>N		No	ClinGen Ensembl
CA3658614 rs765585506	159	H>Y		No	ClinGen ExAC gnomAD
CA362984626 rs1476795410	161	L>P		No	ClinGen TOPMed
rs369129269 CA3658613	162	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs201980135 CA3658612	163	R>C		No	ClinGen ExAC TOPMed gnomAD
CA136175979 rs866438646	163	R>H		No	ClinGen TOPMed gnomAD
TCGA novel	166	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362984418 rs1266770394	168	G>A		No	ClinGen gnomAD
rs760728809 CA3658610	169	I>M		No	ClinGen ExAC gnomAD
rs1025565949 CA136175958	170	V>I		No	ClinGen Ensembl
CA136175952 rs200156457	171	V>A		No	ClinGen 1000Genomes
rs1261411022	171	V>missing	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA136175955 rs1052112552	171	V>I		No	ClinGen TOPMed gnomAD
rs1241409729 CA362984301	172	N>S		No	ClinGen gnomAD
CA3658609 rs773024231	176	Q>E		No	ClinGen ExAC gnomAD
rs767382141 CA3658608	182	I>T		No	ClinGen ExAC gnomAD
rs761346606 CA3658607	183	D>N		No	ClinGen ExAC
CA3658606 rs773822775	184	R>T		No	ClinGen ExAC gnomAD
rs553652359 CA136175916	185	Q>E		No	ClinGen 1000Genomes
CA3658604 rs536734991	186	H>N		No	ClinGen 1000Genomes ExAC gnomAD
CA136175884 rs1003781915	188	Q>E		No	ClinGen Ensembl
rs202045794 CA3658575	190	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA3658576 rs768618881	190	P>S		No	ClinGen ExAC gnomAD
TCGA novel	192	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	192	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3658574 rs780159986	194	A>P		No	ClinGen ExAC gnomAD
CA362982879 rs780159986	194	A>T		No	ClinGen ExAC gnomAD
rs149237704 CA3658573	196	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3658572 rs781301294	200	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1447669370 CA362982763	204	L>P		No	ClinGen gnomAD
CA3658567 rs752209834	205	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs764035206 CA3658568	205	Y>H		No	ClinGen ExAC gnomAD
CA3658566 rs752209834	205	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA3658564 rs759241593	210	Q>E		No	ClinGen ExAC gnomAD
rs1355410740 CA362982700	210	Q>R		No	ClinGen TOPMed
rs1340671612 CA362982672	213	H>Y		No	ClinGen gnomAD
CA3658562 rs772556762	215	A>V		No	ClinGen ExAC gnomAD
rs1468972642 CA362982624	216	V>A		No	ClinGen TOPMed gnomAD
CA3658561 rs145980580	218	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs775008818 CA3658560	221	D>E		No	ClinGen ExAC gnomAD
CA3658559 rs372450488	223	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs374287394 CA3658556	224	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374287394 CA3658558	224	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM3430369 rs746089400 CA3658555 COSM3430370	224	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs374287394 CA3658557	224	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3658554 rs781324865	226	Y>F		No	ClinGen ExAC
rs1410392221 CA362982479	226	Y>H		No	ClinGen gnomAD
rs746759888 CA3658552	227	M>T		No	ClinGen ExAC
CA3658551 rs777605413	228	P>A		No	ClinGen ExAC gnomAD
rs777605413 CA362982454	228	P>T		No	ClinGen ExAC gnomAD

No associated diseases with Q9GZU0

No regional properties for Q9GZU0

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9GZU0

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99LU8		Uncharacterized protein C6orf62 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MGDPNSRKKQ	ALNRLRAQLR	KKKESLADQF	DFKMYIAFVF	KEKKKKSALF	EVSEVIPVMT
70	80	90	100	110	120
NNYEENILKG	VRDSSYSLES	SLELLQKDVV	QLHAPRYQSM	RRDVIGCTQE	MDFILWPRND
130	140	150	160	170	180
IEKIVCLLFS	RWKESDEPFR	PVQAKFEFHH	GDYEKQFLHV	LSRKDKTGIV	VNNPNQSVFL
190	200	210	220
FIDRQHLQTP	KNKATIFKLC	SICLYLPQEQ	LTHWAVGTIE	DHLRPYMPE