Q9GRX6

PR
Gene name
aif (DDB_G0288247)
Protein name
Apoptosis-inducing factor 1, mitochondrial
Names
Ddaif
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0288247
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-117 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9GRX6

Entry ID Method Resolution Chain Position Source
AF-Q9GRX6-F1 Predicted AlphaFoldDB

No variants for Q9GRX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9GRX6

No associated diseases with Q9GRX6

3 regional properties for Q9GRX6

Type Name Position InterPro Accession
active_site Lipase, GDXG, putative histidine active site 87 - 103 IPR002168
domain Alpha/beta hydrolase fold-3 87 - 295 IPR013094
active_site Lipase, GDXG, putative serine active site 159 - 171 IPR033140

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Cytoplasm
  • Nucleus
  • Translocates from mitochondria to the cytoplasm and secondary to the nucleus after the onset of cell death
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
pathogen-containing vacuole A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

6 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

9 GO annotations of biological process

Name Definition
chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
mitochondrial proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane.
mitochondrial respiratory chain complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.
programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
protein import into mitochondrial intermembrane space The import of proteins into the space between the inner and outer mitochondrial membranes.
regulation of mitochondrial depolarization Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
regulation of response to oxidative stress Any process that modulates the frequency, rate or extent of response to oxidative stress.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIRNLTKLTK FTIGNRFYQS SSKGRFSGKN GNNAFKSIVG VSVGVSALFA GCVFLDQEKE
70 80 90 100 110 120
PESTPSIDVK EKKSQPPKTK EDYQKKMDEE YDIEQFKYVI IGGGTAAYHA IDKILENDKE
130 140 150 160 170 180
ATILLISKEY EVPYQRPPLT KSLWATKDDN VVNTLNFSDW SGKKQNLLYE QESAYGNEIL
190 200 210 220 230 240
QFIRTKKVID LHIDEKLVLL NDGKLIRYDK CLIATGGEPR QLKFTSTNDK KISTYRTVED
250 260 270 280 290 300
FRKLYEVVKD GGKHVTVLGG GFLGSELTCA INSNFQDKNI KIDQIFPESG VLSTLFPDYL
310 320 330 340 350 360
SKYATEEIIK SGVNVHTGTL IKDVVDNSEN GRLTVTLNNG KTFETDHVVV AAGIIPNTNV
370 380 390 400 410 420
VKSTTLEIDP INGGYVVNPE LQARTDLYVA GDVASYYDFS LGVRRRVEHH DHARATGEMA
430 440 450 460 470 480
GSNMSTKDTP APYTYQPFFW SDLTPGVGFE AVGNTSSKLK TFSVWEKPSS DETKQSYTKG
490 500 510 520 530
NIYYLNDNNN VVGVLCYGNY GKMDTARDLI LKRRTIEDLN QLQHAIDFDE HH