Q9GLG2

PR
Gene name
CAPN1 (CANPL1, QccE-12457)
Protein name
Calpain-1 catalytic subunit
Names
Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain, muCANP
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
mcf:101867512
EC number
3.4.22.52: Cysteine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9GLG2

Entry ID Method Resolution Chain Position Source
AF-Q9GLG2-F1 Predicted AlphaFoldDB

No variants for Q9GLG2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9GLG2

No associated diseases with Q9GLG2

8 regional properties for Q9GLG2

Type Name Position InterPro Accession
active_site Cysteine peptidase, cysteine active site 109 - 120 IPR000169
domain Peptidase C2, calpain, catalytic domain 37 - 362 IPR001300
domain EF-hand domain 557 - 614 IPR002048-1
domain EF-hand domain 615 - 650 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 628 - 640 IPR018247
domain Peptidase C2, calpain, large subunit, domain III 371 - 514 IPR022682
domain Peptidase C2, calpain, domain III 365 - 522 IPR022683
domain Calpain subdomain III 364 - 524 IPR033883

Functions

Description
EC Number 3.4.22.52 Cysteine endopeptidases
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Translocates to the plasma membrane upon Ca(2+) binding
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEEIITPVY CTGVSAQVQK QRAKELGLGR HENAIKYLGQ DYEQLRARCL QSGTLFRDEA
70 80 90 100 110 120
FPPVPQSLGF KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA
130 140 150 160 170 180
IASLTLNDTL LHRVVPHGQS FQNGYAGIFH FQLWQFGEWV DVVVDDLLPI KDGKLVFVHS
190 200 210 220 230 240
AEGNEFWSAL LEKAYAKVNG SYESLSGGST SEGFEDFTGG VTEWYELRKA PSDLYQIILK
250 260 270 280 290 300
ALERGSLLGC SIDISSVLDM EAITFKKLVK GHAYSVTGAK QVNYRGQMVN LIRMRNPWGE
310 320 330 340 350 360
VEWTGAWSDS SSEWNSVDPY EREQLRVKME DGEFWMSFRD FMREFTRLEI CNLTPDALKS
370 380 390 400 410 420
RTIRKWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LDETDDPDDY GDRESGCSFV
430 440 450 460 470 480
LALMQKHRRR ERRFGRDMET IGFAVYEVPP ELVGQPALHL KRDFFLANAS RARSEQFINL
490 500 510 520 530 540
REVSTRFRLP PGEYVVVPST FEPNKEGDFV LRFFSEKSAG TAELDDQIQA NLPDEQVLSE
550 560 570 580 590 600
EEIDENFKAL FRQLAGEDME ISVKELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD
610 620 630 640 650 660
GNGKLGLVEF NILWNRIRNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK LNKKLYELII
670 680 690 700 710
TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV TFDLFKWLQL TMFA