Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9GL41
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9GL41-F1 | Predicted | AlphaFoldDB |
No variants for Q9GL41
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9GL41 | |||||
No associated diseases with Q9GL41
8 regional properties for Q9GL41
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 83 - 112 | IPR001039-1 |
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 114 - 130 | IPR001039-2 |
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 134 - 151 | IPR001039-3 |
| domain | MHC class I alpha chain, alpha1 alpha2 domains | 180 - 198 | IPR001039-4 |
| conserved_site | Immunoglobulin/major histocompatibility complex, conserved site | 280 - 286 | IPR003006 |
| domain | Immunoglobulin C1-set | 217 - 292 | IPR003597 |
| domain | Immunoglobulin-like domain | 207 - 296 | IPR007110 |
| domain | MHC class I-like antigen recognition-like | 27 - 200 | IPR011161 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| HFE-transferrin receptor complex | A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transferrin receptor binding | Binding to a transferrin receptor. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| iron ion import across plasma membrane | The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol. |
| negative regulation of T cell antigen processing and presentation | Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPRARPALF | FLILLRTVAA | QGRPPRSHSL | RYLFMGASER | DHGLPLFEAL | GYVDDELFVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YNHESRRAES | RAQWVLGEAH | SQLWLQLSQS | LKGWDHMFIV | DFWTIMDNHN | HSKESHTLQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILGCEVQEDN | STRGFWMYGY | DGQDHLEFCP | ETLDWRAAES | RALTTKLEWE | VNKIRAKQNR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AYLERDCPEQ | LQWLLELGRG | VLDQQVPPLV | KVTHHVASAV | TTLRCQALNF | YPQNITMRWL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDRKPVDVKD | AESKDVLPSG | DGTYQSWVAL | AVPPGEEQRY | TCQVEHPGLD | QPLTATWEPS |
| 310 | 320 | 330 | 340 | ||
| LSNTLVTGVI | SGIAVCVIIF | LIGILFRILR | KRQASRGAMG | DYVLAECE |